Efficacy of latex avoidance for primary prevention of latex sensitization in children with spina bifida

Nieto, Antonio; Mazón, Ángel; Pamies, Rafael; Lanuza, Amparo; Muñoz, Alberto; Estornell, F.; García-Ibarra, F

doi:10.1067/mpd.2002.122732

Cited by 48 publications

(30 citation statements)

References 11 publications

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“…The avoidance of latex in children with spina bifida is the cornerstone for the treatment of latex allergy in these children [12] and has also proved efficacious for prevention of latex sensitization [14]. Until an evaluation of specific latex immunotherapy in sensitized children is available, from a practical point of view, it appears that not much more can be done, but these patients represent a unique human experimental natural model for the study of allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

Influence of the type of operations on the development of latex sensitization in children with myelomeningocele

Mazon¹,

Nieto²,

Pamies³

et al. 2005

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Influence of the type of operations on the development of latex sensitization in children with myelomeningocele

Mazon¹,

Nieto²,

Pamies³

et al. 2005

Journal of Pediatric Surgery

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“…Adult patients undergoing multiple surgeries have lower sensitivity than children with spina bifida. The prophylaxis since birth in children with spina bífida is the most effective way to prevent sensitization 1,6,14 . Machado et al 15 reported that children with meningomyelocele are the most sensitive to latex by very frequent and early contact with catheters, gloves, ventricleperitoneal bypasses, among others.…”

Section: Resultsmentioning

confidence: 99%

Prevalência de sinais de sensibilidade ao látex em pacientes com mielomeningocele submetidos a múltiplos procedimentos cirúrgicos

Yeh¹,

Kiohara²,

Soares³

et al. 2012

Rev. Bras. Anestesiol.

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Summary: Yeh WSC, Kiohara PR, Soares ISC, Carmona MJC, Rocha FT, Galvão CES -Prevalence of Sensitivity Signals to Latex in Meningomyelocele Patients Undergoing Multiple Surgical Procedures. Background and objectives:The number of patients allergic to latex has increased significantly. It is crucial to recognize the cases in order to prevent and apply adequate treatment. The objective of this study was to evaluate the prevalence of allergy to latex in meningomyelocele patients.

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“…The experience of multiple surgical procedures exposes these children to a range of rubber products from an early age [37] and is a risk factor for latex allergy [11,12,15] (Table 1). Although efforts to reduce latex exposure during surgery have [25,26] reduced sensitization, especially to proteins of dipped latex products [38,16], the frequent use of in-dwelling catheters may continue to expose these children to the latex proteins of solid rubber products.…”

Section: Latex Allergy -Evolution Of An Epidemic and Beyondmentioning

confidence: 99%

“…Latex-free operating theatres enable latexallergic patients to undergo surgery safely [99]. Spina bifida is often identified in utero or soon after birth, and so allows vigorous latex allergen avoidance, enhancing the efficacy of primary prevention [38,16]. However, these measures present considerable challenges and cost to the healthcare industry and exposure to other forms of natural rubber latex and cross-reactive foods can induce allergic reactions [100].…”

Section: Therapy For Latex Allergy Through Allergen Avoidancementioning

confidence: 99%

Latex allergy: a model for therapy

Rolland

O’Hehir

2008

Clin Experimental Allergy

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Allergy to natural rubber latex products emerged as an important clinical condition following an increase in the use of latex gloves for barrier protection in the early 1980s. In addition to latex glove users, other high-risk groups with different latex exposure include spina bifida patients and others with multiple surgical procedures. Subjects with fruit and vegetable allergy are also at risk due to cross-reactive allergens. Following the significant advances in the identification and characterization of common aeroallergens, latex allergy was well placed to become an excellent model of therapy. Awareness of latex allergy and modes of sensitization enabled epidemiological studies to inform allergen avoidance initiatives, substantially reducing inadvertent exposure in major hospitals in Western countries. Spina bifida is often identified in utero or soon after birth, allowing vigorous latex allergen avoidance with enhanced efficacy of primary prevention. However, changing demographics of latex allergy and technological revolution in countries such as China and India are predicted to unleash a second wave of latex allergy reemphasizing the incentive for improved manufacturing procedures for latex products. The desirable high tensile strength and elasticity of natural rubber latex have made the commercial identification of good alternatives very difficult but this would also be attractive for primary prevention. In addition, an effective specific immunotherapy regimen would be valuable for selected high-risk atopic individuals. Current subcutaneous and sublingual immunotherapy schedules have been tested for treatment of latex allergy with evidence of efficacy but the risks of adverse events are high. For such potent allergens as latex, hypoallergenic but T cell-reactive preparations are required for clinical use. Identification of allergenic components of latex products, with generation of monoclonal antibodies and recombinant allergens, allowed sequence determination and mapping of T cell and B cell epitopes. Together, these reagents and data facilitated improved diagnostics and investigation of novel-specific therapeutics. Potential hypoallergenic latex preparations identified include modified non-IgE-reactive allergen molecules and short T cell epitope peptides. The co-administration of adjunct therapies such as anti-IgE or corticosteroids and of appropriate adjuvants for induction of regulatory T cell response offers promise for clinically effective, safe latex-specific vaccines.

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Efficacy of latex avoidance for primary prevention of latex sensitization in children with spina bifida

Cited by 48 publications

References 11 publications

Influence of the type of operations on the development of latex sensitization in children with myelomeningocele

Influence of the type of operations on the development of latex sensitization in children with myelomeningocele

Prevalência de sinais de sensibilidade ao látex em pacientes com mielomeningocele submetidos a múltiplos procedimentos cirúrgicos

Latex allergy: a model for therapy

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