Efficacy of Laser Photobiomodulation on Morphological and Functional Repair of the Facial Nerve

Buchaim, Daniela Vieira; Andreo, Jesús Carlos; Ferreira, Rui Seabra; Barraviera, Benedito; Rodrigues, Antônio de Castro; Macedo, Mariana de Cássia; Rosa, Geraldo Marco; Shinohara, André Luis; German, Iris Jasmin Santos; Pomini, Karina Torres; Buchaim, Rogério Leone

doi:10.1089/pho.2016.4204

Cited by 32 publications

(52 citation statements)

References 51 publications

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“…With the evolution of the technology in the health field and the evolution of the adjunct methods for rehabilitation and functional restoration of injured nerves [3,6,7,8,9], the PBMT has shown a wide range of benefits with clinical relevance. Thus, the aim of this research was to carry out a review of the scientific papers published in the last 10 years in order to verify the relation of PBMT in the regeneration of injured peripheral nerves.…”

Section: Discussionmentioning

confidence: 99%

“…The functional analysis evidenced the evolution of functional recovery associated with PBMT [6,7,34,38,39]. Marcolino et al [40] found a functional recovery with both 40 J/cm 2 and 80 J/cm 2 (830 nm), Akgul; Gulsoy; Gulcur [41] also scored improvement in functionality with late application PBMT (650 nm) (7 days after injury), as well as Medalha et al [35] at 660 nm at 50 J/cm 2 .…”

Section: Discussionmentioning

confidence: 99%

“…The effects of PBMT on nerve damage were verified in the sciatic nerve in 17 articles [19,30,31,32,33,34,35,36,38,39,41,42,43,44,46,47,49], facial nerve in 3 [3,6,7], fibular nerve in 2 articles [40,48], and vagus nerve [2], accessory nerve [29], alveolar nerve [45], and dorsal root [37] in one article each. Of the 26 articles inserted in this review, it was observed that 14 [19,31,32,37,38,39,40,41,42,44,45,46,48,49] presented compression as nerve damage (crushing) and 11 [2,3,6,7,30,33,34,35,36,43,47] articles evaluated the effects of PBMT on neurotmeses, which is the worst type of nerve injury.…”

Section: Discussionmentioning

confidence: 99%

“…Its effects are related to tissue biostimulation, presenting therapeutic responses from photoelectric, photoenergetic, and photochemical reactions [1]. Scientific research has shown the application of PBMT in bone tissue and peripheral nerves with good results whether or not it is associated with other supporting methods in tissue repair [2,3,4,5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

“…Its beneficial effects are independent of the repair technique, neurorrhaphy techniques, and the use of fibrin sealants [3,6,7,21]. …”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

et al. 2018

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Photobiomodulation therapy (PBMT) has been investigated because of its intimate relationship with tissue recovery processes, such as on peripheral nerve damage. Based on the wide range of benefits that the PBMT has shown and its clinical relevance, the aim of this research was to carry out a systematic review of the last 10 years, ascertaining the influence of the PBMT in the regeneration of injured peripheral nerves. The search was performed in the PubMed/MEDLINE database with the combination of the keywords: low-level laser therapy AND nerve regeneration. Initially, 54 articles were obtained, 26 articles of which were chosen for the study according to the inclusion criteria. In the qualitative aspect, it was observed that PBMT was able to accelerate the process of nerve regeneration, presenting an increase in the number of myelinated fibers and a better lamellar organization of myelin sheath, besides improvement of electrophysiological function, immunoreactivity, high functionality rate, decrease of inflammation, pain, and the facilitation of neural regeneration, release of growth factors, increase of vascular network and collagen. It was concluded that PBMT has beneficial effects on the recovery of nerve lesions, especially when related to a faster regeneration and functional improvement, despite the variety of parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Its beneficial effects are independent of the repair technique, neurorrhaphy techniques, and the use of fibrin sealants [3,6,7,21]. …”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

et al. 2018

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Nerve Repair With Fibrin Nerve Conduit and Modified Suture Placement

Wang

Degrugillier

Tremp

et al. 2018

The Anatomical Record

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Sutureless nerve repair has been regarded as a promising technique for nerve repair as the suture materials often results in neuroma formation and scar tissue that impede nerve regeneration. The aim of this study was to analyze the mechanical stability and morphological outcome of sutureless repair using fibrin glue conduit and an alternative approach of modified suture placement. Using rat sciatic nerve, we tested the following experimental conditions: conventional suture repair; single suture combined with fibrin glue repair, and fibrin conduit reinforced with modified suture or fibrin glue. Nerve detachment anatomical measures such as axon density, myelin, and fiber caliber were analyzed for evaluation of nerve regeneration. Muscle atrophy were evaluated by muscle wet weight and H&E staining. All animals in sutureless repair group exhibited complete detachment or elongation by two or four weeks after repair. No detachment was found in any other groups. Animals treated with fibrin conduit reinforced with modified suture showed better axonal regeneration with good alignment. There were no significant differences in axon caliber among the groups. Muscle atrophy was found in all groups and there was no significant difference in muscle wet-weight among the groups. In summary, sutureless nerve repair with fibrin glue was mechanically unstable for resistance of mechanical stretches, fibrin glue conduit with modified suture placement is mechanically stable and resulted in better morphological outcome.

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Photobiomodulation at a wavelength of 633 nm leads to faster functional recovery than 804 nm after facial nerve injury

Lee

Carpena

Kim

et al. 2021

Journal of Biophotonics

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We analyzed the effects of photobiomodulation (PBM) of various wavelengths on regeneration of the facial nerve using in vitro and in vivo experimental models. We assessed the antioxidative effect of PBM in geniculate ganglion neurons irradiated with a diode laser at 633 nm, 780 nm and 804 nm. Wavelengths of 633 and 780 nm but not 804 nm inhibited cell death by oxidative stress. We assessed the effects of PBM on functional and morphologic recovery in rats divided into control, facial nerve damage (FND) and FND irradiated with a 633 nm or 804 nm lasers. Injured rats treated with 633-nm light had better facial palsy scores, larger axon diameter and higher expression of Schwann cells compared with the FND group. No positive results were observed in rats irradiated at 804-nm light. These findings indicate that 633-nm PBM promotes accelerated nerve regeneration and improved functional recovery in an injured facial nerve.

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Efficacy of Laser Photobiomodulation on Morphological and Functional Repair of the Facial Nerve

Abstract: LLLT enhanced axonal regeneration and accelerated functional recovery of the whiskers, and both repair techniques allowed the growth of axons.

Cited by 32 publications

References 51 publications

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

Nerve Repair With Fibrin Nerve Conduit and Modified Suture Placement

Photobiomodulation at a wavelength of 633 nm leads to faster functional recovery than 804 nm after facial nerve injury

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