Efficacy of laparoscopic resection in elderly patients with colorectal cancer

Miyasaka, Yoshihiro; Mochidome, Naoki; Kobayashi, Kiroku; Ryu, Shinichiro; Akashi, Yoshio; Miyoshi, Akira

doi:10.1007/s00595-013-0753-8

Cited by 21 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All patients were evaluated preoperatively by expert anesthesiologists for individual comorbidities with quantification using the weighted CCI and classification according to the ASA score. The CCI is a method with 22 variables, which was described by Charlson et al [ 7 ], for measuring comorbidity [ 6 7 ]. Antibiotic prophylaxis was given to all patients at the induction of anesthesia in the form of 1 gm of cephalosporin, with a second dose being administered if the surgery exceeded four hours.…”

Section: Methodsmentioning

confidence: 99%

“…Advancing age is considered an important and independent risk factor for postoperative morbidity and mortality; this was confirmed by analysis of the national database in the United States of 975,825 patients aged ≥65 who had undergone a colorectal resection and by a systematic review of 28 independent studies [ 4 6 ]. The aim of this study was to evaluate the impact of age on short-term outcomes after colorectal surgery at a single institution.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Outcome of Colorectal Surgery in Elderly Populations

et al. 2016

View full text Add to dashboard Cite

PurposeThe aim of this study is to investigate the impact of age on short-term outcomes after colorectal surgery in terms of the 30-day postoperative morbidity and mortality rates.MethodsThe subjects for the study were patients who had undergone colorectal surgery. Patients were divided into 2 groups according to age; groups A and B patients were ≥80 and <80 years old of age, respectively. Both groups were manually matched for body mass index, American Society of Anesthesiologists score, Charlson Comorbidity Index and procedure performed.ResultsA total of 200 patients, 91 men (45.5%) and 109 women (54.5%), were included in this retrospective study. These patients were equally divided into 2 groups. The mean ages were 85 years in group A (range, 80 to 104 years) and 55.3 years in group B (range, 13 to 79 years). The overall 30-day postoperative mortality rate was 1% of total 200 patients; both of these 2 patients were in group A. However, this observation had no statistical significance. No intraoperative complications were encountered in either group. The overall 30-day postoperative morbidity rate was 27% (54 of 200) for both groups. The 30-day postoperative morbidity rates in groups A and B were 28% (28 of 100) and 26% (26 of 100), respectively. However, these differences between the groups had no statistical significance importance.ConclusionAge alone should not be considered to be more of a contraindication or a worse predictor than other factors for the outcome after colorectal surgery on elderly patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Outcome of Colorectal Surgery in Elderly Populations

et al. 2016

View full text Add to dashboard Cite

show abstract

“…One reason may be that the poorer function reserve and more serious comorbidities after larger trauma of open surgery may impair the anti-tumor ability of immunologic function, which may cause earlier tumor recurrence and cancer-related death. By contrast, elderly colorectal cancer patients with advanced disease ( 11 , 26 , 27 ), larger tumor size ( 15 , 27 , 28 ) and emergency events ( 10 ) are often advised to undergo open surgery, which may lead to the open surgery group having inferior outcomes.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta-analysis

Wang

Zhao

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

The long-term outcome of laparoscopic surgery for geriatric patients with colorectal cancer remains unclear due to decreased functional reserves and increased medical comorbidities. A meta-analysis was performed in the present study to compare the long-term outcome between laparoscopy and laparotomy. Randomized controlled trials and comparative studies regarding laparoscopy vs. open surgery for colorectal cancer in elderly patients were searched in Pubmed, Embase, and Cochrane library between inception and April 20, 2017. The methodological quality of the cohort studies was evaluated using the Newcastle-Ottawa Scale. The meta-analysis was performed using Stata v12.0 software. Eight cohort studies were enrolled in the meta-analysis. Laparoscopic surgery was associated with a higher 3-year survival rate compared with open surgery [risk ratio (RR), 0.74; 95% confidence interval (CI), 0.61–0.90; P=0.003]. No significant difference was identified between laparoscopy and laparotomy regarding the 5-year survival rate (RR, 0.93; 95% CI, 0.78–1.11, P=0.424). The results of the meta-analysis indicated that the use of laparoscopic surgery on geriatric patients with colorectal cancer should be increased due to more improved long-term outcomes. All the studies included in the meta-analysis were case-control studies with selection bias and other confounding factors. Thus, larger sample sizes and multicenter randomized controlled trials are required to further validate the use of laparoscopic surgery as the preferred therapeutic option for elderly patients with colorectal cancer.

show abstract

“…[6], посвященное оценке эффективности лапароскопического лечения колоректального рака у больных старше 80 лет по сравнению с более молодыми пациентами, не выявило различий между группами по срокам послеоперационной реабилитации и частоте осложнений. Эти выводы подтверждаются работами других авторов [18][19][20].…”

Section: Discussionunclassified