Efficacy of lamotrigine in painful diabetic neuropathy: Results from two large double-blind trials

Safirstein, Beth; Tuchman, Michael; Dogra, Sunil; Engel, Samuel S.; Blum, David; Silver, Marianne T.; Grainger, J.; Quessy, Steve

doi:10.1016/j.jpain.2005.01.131

Cited by 7 publications

(2 citation statements)

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“…Of the second‐generation anticonvulsants, RCTs have been conducted examining lamotrigine, oxcarbazepine, topiramate, and zonisamide for the treatment of DPNP. Lamotrigine demonstrated efficacy in one clinical trial of 59 patients with DPNP [48], but results of intention‐to‐treat analyses were negative in two recent large trials of DPNP [49]. For oxcarbazepine, one positive and several unpublished trials [50] have been accompanied by an announcement that its development as a potential treatment for neuropathic pain has been discontinued.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology, Public Health Burden, and Treatment of Diabetic Peripheral Neuropathic Pain: A Review

et al. 2007

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Section: Resultsmentioning

confidence: 99%

Epidemiology, Public Health Burden, and Treatment of Diabetic Peripheral Neuropathic Pain: A Review

et al. 2007

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“…61 Most recently, two large multicenter trials in patients with diabetic neuropathy each failed to demonstrate pain reduction compared with placebo in intention-to-treat analyses of the primary endpoint of pain reduction, and a relatively high dropout rate may have reflected poorer tolerability at higher dosages (Ͼ 300 mg daily). 84 Therapeutic liabilities include relatively high incidence of rash and drug-drug interactions.…”

Section: Lamotriginementioning

confidence: 99%

Ion Channel Targets and Treatment Efficacy in Neuropathic Pain

Markman

Dworkin

2006

The Journal of Pain

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Interventional Approaches to Pain Management

Markman

Philip

2007

Anesthesiology Clinics

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This article reviews the evidence for several common interventional techniques for the treatment of chronic pain, including: intraspinal delivery of analgesics, reversible blockade with local anesthetics, augmentation with spinal cord stimulation, and ablation with radiofrequency energy or neurolytic agents. The role of these techniques is defined within the framework of a multidisciplinary approach to the neurobehavioral syndrome of chronic pain. Challenges to the study of the analgesic efficacy of procedural interventions are explored, as are the practical issues raised by their clinical implementation, with the aim of helping nonspecialist physicians identify the patients most likely to benefit from these approaches.

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Efficacy of lamotrigine in painful diabetic neuropathy: Results from two large double-blind trials

Cited by 7 publications

References 0 publications

Epidemiology, Public Health Burden, and Treatment of Diabetic Peripheral Neuropathic Pain: A Review

Epidemiology, Public Health Burden, and Treatment of Diabetic Peripheral Neuropathic Pain: A Review

Ion Channel Targets and Treatment Efficacy in Neuropathic Pain

Interventional Approaches to Pain Management

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