Efficacy of Lactoferrin with Standard Triple Therapy or Sequential Therapy for Helicobacter pylori Eradication: A Randomized Controlled Trial

Hablass, Fahmy H; Lashen, Sameh A; Al‐Sayed, Eman

doi:10.5152/tjg.2021.20923

Cited by 10 publications

(10 citation statements)

References 29 publications

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“…Hablass et al designed antibiotic therapy (clarithromycin + amoxicillin/metronidazole +PPI) in combination with bovine lactoferrin to treat H. pylori positive volunteers. The combined treatment group had a successful eradication rate of 85.6%, compared with 70.3% for the lactoferrin-free group, suggesting that lactoferrin may improve the efficacy of antibiotic therapy ( Hablass et al, 2021 ). In summary, the use of lactoferrin in the treatment of H. pylori infection has been shown to be effective in increasing the success rate.…”

Section: Main Treatment Methodsmentioning

confidence: 99%

Helicobacter pylori infection in humans and phytotherapy, probiotics, and emerging therapeutic interventions: a review

Liu,

Gao,

Miao

et al. 2024

Front. Microbiol.

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The global prevalence of Helicobacter pylori (H. pylori) infection remains high, indicating a persistent presence of this pathogenic bacterium capable of infecting humans. This review summarizes the population demographics, transmission routes, as well as conventional and novel therapeutic approaches for H. pylori infection. The prevalence of H. pylori infection exceeds 30% in numerous countries worldwide and can be transmitted through interpersonal and zoonotic routes. Cytotoxin-related gene A (CagA) and vacuolar cytotoxin A (VacA) are the main virulence factors of H. pylori, contributing to its steep global infection rate. Preventative measures should be taken from people’s living habits and dietary factors to reduce H. pylori infection. Phytotherapy, probiotics therapies and some emerging therapies have emerged as alternative treatments for H. pylori infection, addressing the issue of elevated antibiotic resistance rates. Plant extracts primarily target urease activity and adhesion activity to treat H. pylori, while probiotics prevent H. pylori infection through both immune and non-immune pathways. In the future, the primary research focus will be on combining multiple treatment methods to effectively eradicate H. pylori infection.

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Section: Main Treatment Methodsmentioning

confidence: 99%

Helicobacter pylori infection in humans and phytotherapy, probiotics, and emerging therapeutic interventions: a review

Liu,

Gao,

Miao

et al. 2024

Front. Microbiol.

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“…Thus, they concluded that b-LF might improve H. pylori eradication rates without any increase in adverse effects [80]. Furthermore, the recent report by Hablass et al in 2021 demonstrated the same efficacy of LF supplementation in the PPI-based triple therapy or sequential therapy for H. pylori eradication [81]. In summary, although there are some conflicting results, the supplementation of b-LF may have an add-on effect on the proton pump inhibitor-based triple therapy for H. pylori eradication [77].…”

Section: The Effect Of B-lf Supplementation On H Pylori Eradication T...mentioning

confidence: 96%

Antimicrobial Effects of Lactoferrin against Helicobacter pylori Infection

Imoto¹,

Yasuma

D’Alessandro-Gabazza

et al. 2023

Pathogens

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Helicobacter (H.) pylori is the primary causative agent of various gastroduodenal diseases. H. pylori is an adapted microorganism that has evolved to survive in the acidic conditions of the human stomach, possessing a natural strategy for colonizing harsh environments. Despite the implementation of various eradication regimens worldwide, the eradication rate of H. pylori has decreased to less than 80% in recent years due to the emergence of antibiotic-resistant strains. This has posed a significant challenge in treating H. pylori infection, as antibiotic resistance and side effects have become increasingly problematic. Lactoferrin, a member of the transferrin family, is an iron-binding protein with antioxidant, antibacterial, antiviral, and anti-inflammatory properties that promote human health. The concentrations of lactoferrin in the gastric juice and mucosa significantly increase during H. pylori infection and are strongly correlated with the severity of gastric mucosal inflammation. Numerous researchers have studied the antimicrobial properties of lactoferrin both in vitro and in vivo. In addition, recent studies have investigated the addition of oral lactoferrin supplementation to H. pylori eradication therapy, even though monotherapy with lactoferrin does not eradicate the microorganism. In this article, we reviewed the survival strategy of H. pylori to evade the antimicrobial activity of human lactoferrin and explore the potential of lactoferrin in H. pylori eradication therapy.

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“…A recent parallel RCT included 400 adult patients with H. pylori infection [ 107 ]. They were randomized into four equal groups: (A) proton-pump-based triple therapy (PpTT) involving proton pump inhibitors: esomeprazole plus antibiotics: amoxicillin and clarithromycin for 2 weeks, (B) esomeprazole plus amoxicillin for 5 days and then esomeprazole plus metronidazole and clarithromycin 10 days, (C) PpTT as in group A plus bLF in 200 mg sachets (overall daily dose 400 mg) for 2 weeks and (D) sequential therapy as in group B plus bLF for 2 weeks, as above.…”

Section: Lactoferrin As Supportive Therapy In Antibiotic Treatmentmentioning

confidence: 99%

Colostrum and Lactoferrin Protect against Side Effects of Therapy with Antibiotics, Anti-inflammatory Drugs and Steroids, and Psychophysical Stress: A Comprehensive Review

Artym

Zimecki

2023

Biomedicines

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In this article, we review the benefits of applying bovine colostrum (BC) and lactoferrin (LF) in animal models and clinical trials that include corticosteroid application and psychic stress, treatment with non-steroid anti-inflammatory drugs (NSAIDs) and antibiotics. A majority of the reported investigations were performed with native bovine or recombinant human LF, applied alone or in combination with probiotics, as nutraceutics and diet supplements. Apart from reducing adverse side effects of the applied therapeutics, BC and LF augmented their efficacy and improved the wellness of patients. In conclusion, LF and complete native colostrum, preferably administered with probiotic bacteria, are highly recommended for inclusion in therapeutic protocols in NSAIDs and corticosteroid anti-inflammatory, as well as antibiotic, therapies. These colostrum-based products can also be of value for individuals subjected to prolonged psychophysical stress (mediated by endogenous corticosteroids), especially at high ambient temperatures (soldiers and emergency services), as well as physically active people and training athletes. They are also recommended for patients during recovery from trauma and surgery, which are always associated with severe psychophysical stress.

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Efficacy of Lactoferrin with Standard Triple Therapy or Sequential Therapy for Helicobacter pylori Eradication: A Randomized Controlled Trial

Cited by 10 publications

References 29 publications

Helicobacter pylori infection in humans and phytotherapy, probiotics, and emerging therapeutic interventions: a review

Helicobacter pylori infection in humans and phytotherapy, probiotics, and emerging therapeutic interventions: a review

Antimicrobial Effects of Lactoferrin against Helicobacter pylori Infection

Colostrum and Lactoferrin Protect against Side Effects of Therapy with Antibiotics, Anti-inflammatory Drugs and Steroids, and Psychophysical Stress: A Comprehensive Review

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