Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia

New Therapeutic Targets in Cardiology

“…In addition, a study of 18 patients with a typical history of inappropriate sinus tachycardia showed that HR was significantly reduced by ivabradine and that tolerance to physical activity was increased, with a progressive rise in maximal load reached. 103 Ivabradine has also been suggested to alleviate symptoms related to the postural orthostatic tachycardia syndrome. In a retrospective study of 18 patients, 8 patients reported reduced tachycardia and fatigue, 4 patients reported only reduced tachycardia, and 6 patients did not experience benefits.…”

2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: Executive Summary

“…Oral digoxin or amiodarone may be reasonable for ongoing treatment of AVNRT in patients who are not candidates for, or prefer not to undergo, catheter ablation. 50,67 e484 Circulation…”

The Choice Of Optimal Coronary Stents: Is It Possible To Maximize Cost-Effectiveness?

“…In other two studies, there are some follow up after the observational treatment. In one Calò et al [21] reported the efficacy of Ivabradine administration in 16 consecutive patients followed up to 6 months. Data from this study suggest that Ivabradine significantly reduces the mean and maximum 24-h HR and that its impact on HR reduction tends to improve over time, as suggested by the greater degree of change observed at 6 months compared with that observed at 3 months.…”

“…Small studies [3,4,5] and several case reports have demonstrated the potential value of Ivabradine, the first selective sinus node If channel inhibitor, to treat IST. Ivabradine can have a dramatic effect on heart rate and can slow it from a mean 100 beats/min to fewer than 75 beats/min.…”