Efficacy of Ipecac and Activated Charcoal/Cathartic

Curtis, Robert A.

doi:10.1001/archinte.1984.00350130054011

Cited by 108 publications

(3 citation statements)

References 43 publications

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“…The disadvantages of ipecacuanha induced emesis are the time before vomiting occurs and the variability in response between patients. The average time to emesis in this study was 20min and is similar to that quoted by other authors (Curtis et al, 1984, Neuvonen et al, 1983, Tenenbein et al, 1987. Two patients had a delay of 50 minutes and a further two patients did not vomit at all.…”

Section: Discussionsupporting

confidence: 91%

“…Three trials have compared activated charcoal with either gastric lavage or emesis by measuring the amount of ingested drug absorbed by volunteers (Curtis et al, 1984;Neuvonen et al, 1983;Tenenbein et al, 1987). All three trials showed activated charcoal to be significantly more effective at limiting drug absorption than either gastric lavage or emesis.…”

Section: Discussionmentioning

confidence: 99%

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A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

Underhill

Greene

Dove

1990

Emergency Medicine Journal

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SUMMARYThe aim of this prospective trial was to compare the efficacy of gastric lavage, activated charcoal and ipecacuanha at limiting the absorption of paracetamol in overdose and to assess the significance of the continued absorption of paracetamol following treatment. Patients aged 16 and over who had ingested 5 gms or more of paracetamol within 4 h of admission were entered into the trial. The percentage fall in plasma paracetamol level was used as the measure of the success of a treatment at limiting absorption. The mean percentage fall was 39-3 for gastric lavage, 52-2 for activated charcoal and 40.7 for ipecacuanha, with a significant difference between the treatment methods (p = 0.03). Activated charcoal was more effective at limiting the absorption of paracetamol following overdose than either gastric lavage or ipecacuanha induced emesis. In treated patients continuing paracetamol absorption is not significant if more than 2 h have elapsed since ingestion.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

Underhill

Greene

Dove

1990

Emergency Medicine Journal

View full text Add to dashboard Cite

show abstract

“…Antiplatelet effects may also provide beneficial effects in ischemic heart disease. Toxicity Range: Diltiazem-patients have survived ingestion up to 12 grams, yet there are reports of fatalities following ingestion ranging from 0.7 to 2.88 grams. Nifedipine-patients have survived ingestion up to of 900 mg, though as little as 50 mg can yield symptoms in the elderly.…”

Section: Calcium Antagonistsmentioning

confidence: 99%

Drug Poisoning and Overdose for the Health Professional: Review of Select Over-the-Counter (OTC) and Prescription Medications

Laven¹,

Oller²

2000

Journal of Pharmacy Practice

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Exposure to over-the-counter and prescription medications can pose significant therapeutic and health hazards to patients, and present health care professionals with scenarios that require proper assessment and treatment. Knowing when an exposure to or overdose of a drug requires emergency medical attention is equally as important as to knowing when such assistance is not necessary—that simple treatment measures performed at home will suffice. This current discussion is intended to highlight select principles and clinical information pertaining to common drug exposures and overdoses, but not replace the full spectrum of information that would be available to health care professionals (and the lay public) by contacting their nearest poison control center. Many of the basic principles and concerns that are encountered with exposures to chemicals (i.e., route of exposure, patient medical history, quantity of the substance involved, elapsed time since the initial exposure, etc.) apply equally well to drug exposures. Likewise, evaluating each of these variables will determine which type of treatment approaches are, and are not, considered in situations of drug (or chemical) exposure and overdose.

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Pediatric Gastrointestinal Decontamination in Acute Toxin Ingestion

Phillips

Gomez

Brent

1993

The Journal of Clinical Pharma

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The appropriate implementation of the various modalities of gastrointestinal (GI) decontamination is critical in the management of the pediatric patient who is examined in the emergency department or private office after an acute ingestion. Gastrointestinal decontamination includes gastric lavage, syrup of ipecac, activated charcoal, and whole bowel irrigation. Clinical studies have delineated the role and efficacy of these procedures. Trends in GI decontamination place less emphasis on ipecac and gastric lavage and more emphasis on activated charcoal alone in the patient with a mild overdose. Gastric lavage is indicated in serious ingestion and is most effective if done soon after the exposure. Whole bowel irrigation is the newest addition and has important clinical use in the treatment of serious iron ingestions as well as in older adolescent cocaine body suffers and packers. Indications and contraindications of the various forms of GI decontamination are discussed and relevant clinical studies are reviewed.

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Efficacy of Ipecac and Activated Charcoal/Cathartic

Cited by 108 publications

References 43 publications

A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

Drug Poisoning and Overdose for the Health Professional: Review of Select Over-the-Counter (OTC) and Prescription Medications

Pediatric Gastrointestinal Decontamination in Acute Toxin Ingestion

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