Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome

Mikati, Mohamad A.; Saab, Raya; Fayad, Michel; Choueiri, Roula

doi:10.1016/s0887-8994(01)00402-7

Cited by 62 publications

(33 citation statements)

References 10 publications

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“…The efficacy of intravenous immunoglobulin in patients with CSWS has yet to be demonstrated (Arts et al, 2009), but promising results have been reported in a few cases of AEA (Fayad et al, 1997;Lagae et al, 1998;Mikati and Saab, 2000;Mikati and Shamseddine, 2005;Mikati et al, 2002).…”

Section: Immune Modulation Therapymentioning

confidence: 99%

Continuous Spike and Waves During Sleep and Electrical Status Epilepticus in Sleep

Loddenkemper

Fernández²,

Peters³

2011

Journal of Clinical Neurophysiology

105

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Continuous spike and waves during sleep is an age-related epileptic encephalopathy that presents with neurocognitive regression, seizures, and an EEG pattern of electrical status epilepticus during sleep. Patients usually present around 5 years of age with infrequent nocturnal unilateral motor seizures that progress within 1 to 2 years to a severe epileptic encephalopathy with frequent seizures of different types, marked neurocognitive regression, and an almost continuous spike-wave EEG pattern during slow-wave sleep. The pathophysiology of continuous spike and waves during sleep is not completely understood, but the corticothalamic neuronal network involved in physiologic oscillating patterns of sleep is thought to be switched into a pathologic discharging mode. Early developmental injury and/or genetic predisposition may play a role in the potentiation of age-related hyperexcitability in the immature brain. A better understanding of the mechanisms leading to electrical status epilepticus during sleep may provide additional therapeutic targets that can improve the outcome of seizures, EEG pattern, and cognitive development in patients with continuous spike and waves during sleep.

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Section: Immune Modulation Therapymentioning

confidence: 99%

Continuous Spike and Waves During Sleep and Electrical Status Epilepticus in Sleep

Loddenkemper

Fernández²,

Peters³

2011

Journal of Clinical Neurophysiology

105

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show abstract

“…Once the diagnosis of LKS is made, medical treatment must be initiated as this appears to improve long-term prognosis [12][13][14]. Despite the number of patients reported in the past 10 years with this syndrome there is no consensus in the literature regarding medical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Other drugs which reduce interictal epileptiform discharges such as Valproic acid may be used. In LKS unresponsive to the above therapies, anecdotal beneficial effect of intravenous immunoglobulin (IVIG) has been reported [12,13].…”

Section: Discussionmentioning

confidence: 99%

Landau–Kleffner syndrome: A rare Auditory Processing Disorder

Fandiño

Connolly

Usher

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…Sideeffects of corticosteroids can be problematic [35]. Intravenous immunoglobulin has been used both with good effect [36] and no effect [37]. LKS refractory to pharmacologic treatment may be considered for multiple subpial transaction (MST).…”

Section: Rehabilitation Issues In Landau-kleffner Syndromementioning

confidence: 99%