Efficacy of Intravaginal Progesterone Administration Combined with Prostaglandin F2.ALPHA. for Cystic Ovarian Disease in Japanese Black Cows

Abstract

ABSTRACT. The objective of this study was to investigate cystic ovarian disease (COD) in commercial Japanese Black cows and to evaluate the efficacy of 7-day insertion of an intravaginal progesterone insert (CIDR) combined with prostaglandin F 2α (PGF 2α ) at CIDR removal. Experiment 1 was conducted to group cysts into 4 patterns based on alteration of plasma progesterone (P 4 ) concentrations on d -7 and d 0 (=CIDR insertion) with 1.0 ng/ml as the cut-off level by ultrasonographic examination of 28 cows with COD that were ≥40 days postpartum and anoestrous after calving. In Experiment 2, a total of 55 cows under the same conditions as in Experiment 1 were utilized, and the same regimen as in Experiment 1 was performed without 7 days of pre-observation before treatment. As a result, 92.9% of CLs on d 21 were highly formed in Experiment 1 and 83.6% were highly formed in Experiment 2. The conception rates within 60 days after CIDR removal were also satisfactory high and were 71.4% and 54.5%, respectively. There were no differences in any overall reproductive parameters between Experiments 1 and 2 (P>0.05). The average days between CIDR removal and conception were 24.4 ± 5.3 and 24.0 ± 6.5 days, respectively (P>0.05); therefore, the conception dates of the cows in Experiment 2 were at least 7 days earlier compared with Experiment 1. In conclusion, treatment with a CIDR and PGF 2α against COD could minimize the risk of incorrect treatment and provide sufficient reproductive performance in Japanese Black cows. KEY WORDS: CIDR, cystic ovarian disease, Japanese Black cattle.J. Vet. Med. Sci. 70(10): 1077-1083, 2008 Cystic Ovarian Disease (COD) is one of the important costly issues for reproductive performance in cattle due to longer infertility as the condition persists [13]. Generally, there are two types of cysts, follicular (FC) and luteal cysts (LC); however, 20% [25] to nearly 70% [31] of cystic ovaries can recover spontaneously. A broad range of treatment strategies against COD have been carried out in the field and reviewed [3,26]. Short-term treatments have been approached from the perspective of manual rupture, administration of products for improvement of liver function or use of exogenous hormones, gonadotropin-releasing hormone (GnRH), human chorionic gonadotropin (hCG) or estradiol, which is now the most popular strategy for treatment of an FC [3,26]. Exogenous progesterone treatment, either intravaginaly or intramuscularly has also been reported for COD treatment either alone or with GnRH or estradiol [1, 5, 7, 13, 16-17, 28-29, 33]. On the other hand, follicles with luteinized structures or an LC should be treated with PGF 2α if diagnosed properly [26,30].The Controlled Internal Drug Release (CIDR) is one of the valuable devices for solving several reproductive issues in cattle and sheep/goat by providing an artificial luteal phase during its insertion by consecutive delivery of progesterone. CIDR insertion can reduce the LH pulse frequency and induce atresia of cystic follicles and normal estrus can be...

Polish Journal of Veterinary Sciences

“…The recovery rates, conception rates and days to conception did not differ between follicular and luteal cysts. Iwakuma et al (2008) evaluated the efficacy of 7-day insertion of CIDR combined with prostaglandin F 2 α at CIDR removal in the treatment of COF > 40 days p.p. The conception rates within 60 days after CIDR removal were above 50%.…”

“…Various progesterone releasing intravaginal devices, such as the progesterone-releasing intravaginal device (PRID) and the controlled internal drug-releasing insert (CIDR) have been used in the treatment of COF. However, there were only few studies about the treatment of COF occurring after puerperium with progesterone inserts and the results were inconsistent (Douthwaite and Dobson 2000, Zulu et al 2003, Ambrose et al 2004, Iwakuma et al 2008.…”

Ovarian cysts in cattle

“…Oestrus rates ranging from 82 to 100% and conception rates at 1 st oestrus ranging from 18 to 28% have been reported after treatment with P4 (Douthwaite and Dobson, 2000;Zulu et al, 2003). According to Iwakuma et al (2008), treatment of OC with the CIDR implant followed by PGF 2α upon removal ensured good reproductive performances.…”

Efficacy of ovulation synchronization with timed artificial insemination in treatment of follicular cysts in dairy cows

“…Cows receiving these treatments are monitored carefully for estrous sings and inseminated at the first post-treatment estrus. Such treatment regimens, however, have been associated with prolonged treatment-to-insemination intervals [5,9,12,13,19,20] with difficulties to differentiate between recovery in response to treatment and spontaneous recovery [21].…”