Efficacy of Intralesional Steroid Injection in Head and Neck Hemangioma

Prasetyono, Theddeus O.H.; Djoenaedi, Intania

doi:10.1097/sap.0b013e3181d49f52

Cited by 24 publications

(21 citation statements)

References 25 publications

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“…208 After corticosteroid injection, large studies have reported accelerated regression in 77% to 100% of patients with IH and cessation of growth in 16% to 23%. [210][211][212][213][214][215][216][217][218][219] The effects of the steroid last approximately 3 to 4 weeks 216 and thus patients may require additional treatments during the proliferating phase for rebound growth.…”

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

“…Subsequently, numerous studies have suggested that intralesional corticosteroid injection is a safe and effective treatment of IH. [210][211][212][213][214][215][216][217][218][219] In general, corticosteroid injection is reserved for small, bulky, welllocalized IH lesions. Large or diffuse IHs are more difficult to manage with intralesional corticosteroids because of the following: (1) a large volume of injectable steroid is more likely to cause systemic adverse effects 220 and (2) it is difficult to evenly distribute the corticosteroid throughout a large tumor.…”

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

“…However, in appropriately selected lesions, many authors consider intralesional corticosteroid injection an effective intervention, given its effectiveness and the relatively low frequency of reported systemic adverse effects at low doses (#2-3 mg/kg). [210][211][212][213][214][215][216][217][218][219] In most studies, patients were injected with either triamcinolone alone or a mixture of triamcinolone and betamethasone, at total equivalent doses of triamcinolone doses of ,3 mg/kg, by using a 27-or 30-gauge needle. 218 The interval between injections varied from 1 to 6 weeks.…”

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

“…[210][211][212][213][214][215][216][217][218][219] In most studies, patients were injected with either triamcinolone alone or a mixture of triamcinolone and betamethasone, at total equivalent doses of triamcinolone doses of ,3 mg/kg, by using a 27-or 30-gauge needle. 218 The interval between injections varied from 1 to 6 weeks. 208 After corticosteroid injection, large studies have reported accelerated regression in 77% to 100% of patients with IH and cessation of growth in 16% to 23%.…”

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

See 3 more Smart Citations

Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

211

290

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Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its purpose is to update the pediatric community regarding recent discoveries in IH pathogenesis, treatment, and clinical associations and to provide a basis for clinical decision-making in the management of IH.

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Section: Intralesional Corticosteroidsmentioning

confidence: 99%

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

Section: Intralesional Corticosteroidsmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

211

290

View full text Add to dashboard Cite

show abstract

“…Gangopadhyay et al reported that overall response rate was 88.6% with administration of intralesional triamcinolone and no side effects occurred (16). Another two studies also showed response rates of up to 90% with intralesional corticosteroid treatment (17,18). Similarly, we demonstrated partial response in 83.3% of patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of intralesional corticosteroid application for hemangiomas

Emir¹,

Gökçebay²,

Demirel³

et al. 2015

Turk J Med Sci

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Background/aim: There are different modalities for management of infantile hemangiomas (IHs). In this report, our aim is to evaluate whether intralesional corticosteroid treatment is associated with systemic side effects and whether this is an effective treatment modality for IH.Materials and methods: Six children treated with intralesional corticosteroids for problematic hemangiomas were included in the study. Clinical characteristics, response to treatment, weight, height, blood pressure, morning serum cortisol, and adrenocorticotropic hormone levels were recorded.Results: Each child received intralesional triamcinolone at a dose of 2 mg/kg for 2-5 injections at monthly intervals. Subjects were followed for 1 year. All patients had adrenal suppression following the second or third triamcinolone injections. Five patients demonstrated partial response and one demonstrated no response. Conclusion:Intralesional steroid injection may effectively induce the resolution of hemangiomas, but all the patients in our group had adrenal suppression after treatment. The use of intralesional steroid therapy is not a superior treatment option for hemangiomas. It also has side effects comparable to systemic steroids.

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Management of Infantile Hemangiomas

Craiglow

Antaya

2013

Pediatr Drugs

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Infantile hemangiomas (IH), benign vascular neoplasms, are the most common tumors of infancy and childhood. Most IH are medically insignificant; however, a proportion will require treatment because of interference with vital structures, threat of significant disfigurement, ulceration, or bleeding. This article reviews current and potential pharmacotherapeutic approaches to the treatment of IH. While corticosteroids have long been considered the mainstay of medical therapy for IH, several new treatments have recently emerged, the most promising of which is oral propranolol. Topical timolol and imiquimod are additional new therapies that may also prove to be effective, particularly for the treatment of superficial IH.

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Efficacy of Intralesional Steroid Injection in Head and Neck Hemangioma

Abstract: Intralesional steroid injection is a good option for treating head and neck hemangioma at proliferative phase with relatively low complications.

Cited by 24 publications

References 25 publications

Diagnosis and Management of Infantile Hemangioma

Diagnosis and Management of Infantile Hemangioma

Efficacy and safety of intralesional corticosteroid application for hemangiomas

Management of Infantile Hemangiomas

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