Efficacy of Intralesional Steroid Injection in Small Benign Vocal Fold Lesions

Ramavat, Anurag Snehi; Tiwana, Harsimran; Banumathy, N; Bakshi, Jaimanti; Panda, Naresh K.; Goel, Ashish

doi:10.1016/j.jvoice.2018.04.008

Cited by 10 publications

(4 citation statements)

References 19 publications

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“…Among benign vocal fold lesions (BVFLs), minimal associated pathological lesions, including vocal fold (VF) polyp, nodules, Reinke's edema, cyst, and vocal process granuloma, represent a distinct clinical and pathological entity. Pathophysiologically, they usually occur due to acute or chronic voice forcing (phonotrauma) and usually have the same predisposing factors as smoking, or inhaled irritants [1] .…”

Section: Introductionmentioning

confidence: 99%

Office-Based Steroid Injection in Benign Vocal Fold Lesions

Baraka

Behairy

Desouky

et al. 2021

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Background: Benign vocal fold lesions (BVFLs) are usually caused by vocal abuse or misuse. Conservative treatment and micro laryngeal surgery (MLS) are recommended in the treatment. However, conservative measures are usually difficult to perform and some patients are contraindicated for general anesthesia.Objective: This study is designed to assess the practical application, effectiveness, and side effects of office-based steriod injection via a transnasal route. Patients and Methods: This study included 29 patients with BVFLs. Transnasal endoscopic steroid injection (TESI) was performed via operating channel for all patients. Local anesthesia was used to inject betamethasone into Reinke's space at the base of the lesion. Acoustic analysis, including fundamental frequency (F0), jitter, shimmer, noise to a harmonic ratio (NHR), aerodynamic analysis (MPT), auditory perceptual assessment using modified GRBAS scale, videolaryngostroboscopy (VLS) evaluations, and voice handicap index (VHI), was done before and three months after TESI. Results: Three months after injection, the VLS demonstrated that remission in size or lesions improvement was observed in 20 patients, total disappearance in 4 patients, and no improvement in 5 patients. The summation of the modified GRBAS scale also indicated highly significant improvement after TESI (P < 0.01). MPT showed a highly significant increase post-injection. VHI showed a highly significant reduction post-injection. Acoustic analysis revealed significant improvements in F0, jitter, shimmer, and NHR (P <0.05). Conclusion: : Office-based TESI is an effective, safe, easy, and feasible alternative treatment method in some BVFLs.

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Section: Introductionmentioning

confidence: 99%

Office-Based Steroid Injection in Benign Vocal Fold Lesions

Baraka

Behairy

Desouky

et al. 2021

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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“…VFSI has been reported to be effective in the treatment of vocal nodules, chorditis, vocal polyps, RE, vocal scars, mucus retention cysts, and laryngeal granulomas. 1 , 2 , 3 , 6 , 10 , 11 , 17 , 18 , 19 However, no report has focused on the patient's characteristics. Although VFSI is an effective treatment for BVFL, it has some side effects, such as vocal fold muscle atrophy.…”

Section: Discussionmentioning

confidence: 99%

“…The basis of our treatment for BVFL is conservative, such as medication and voice therapy. VFSI has been reported to be effective in the treatment of vocal nodules, chorditis, vocal polyps, RE, vocal scars, mucus retention cysts, and laryngeal granulomas 1–3,6,10,11,17–19 . However, no report has focused on the patient's characteristics.…”

Section: Discussionmentioning

confidence: 99%

Age‐dependent treatment effect of vocal fold steroid injection for benign vocal fold lesions

Nozawa

Kanazawa

Kurakami

et al. 2023

Laryngoscope Investig Oto

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Objective: Benign vocal fold lesions (BVFLs) cause voice disorders and impair social life. Recently, office-based vocal fold steroid injection (VFSI) has gained attention as a minimally invasive treatment for BVFLs. This study aimed to analyze the agedependent treatment effect of VFSI and to clarify the indications for treatment.Methods: In this retrospective cohort study, a total of 83 patients with BVFLs were treated with a similar regimen of VFSI. Three or four months after the injection, agedependent phonological functions were evaluated. The differences between pre-and post-treatment findings were analyzed using the Wilcoxon matched-pair signed-rank test, and the correlation between patient age and improvement rates were determined by Pearson's correlation coefficient.Results: Improvement in voice handicap index (VHI), which was the primary endpoint, was observed. Subjective and objective voice quality measurements also showed significant improvements. Subgroup analyses revealed that there was no age-related difference in the improvement of voice quality and that there was no improvement in aerodynamic effect in patients over 45 years of age. Conclusion:This study clarified the age-dependent treatment effect of VFSI and provided the important suggestion of establishing indication criteria for BVFLs. The study results provided clarity on the indication criteria of VFSI and served as an important indicator for tailoring treatment to patients' needs.

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“…5 Yine küçük boyutta vokal kord poliplerine intralezyoner steroid uygulanmasının, epitel hasarı ve yüzeyel lamia proriada zedelenmeye yol açmadan ses kalitesini düzelttiği gösterilmiştir. 12 Son dekadda ise lazer vaporizasyon yöntemi, benign vokal kord lezyonlarında da malignitelerde olduğu kadar sık kullanılmamakla birlikte, giderek yaygınlaşmaya başlamıştır. Genel anestezi alamayacak veya istemeyen vakalarda lokal anestezi ile ofis koşullarında yapılan girişimler maliyetinin daha az olması nedeni ile tercih edilmeye başlanmış olup, henüz geniş vaka serileriyle uzun dönem karşılaştırmalı sonuçları bulunmamaktadır.…”

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Objective Evaluation Regarding Efficacy of Endolaryngeal Microsurgery

Tüzüner¹,

Bahçecitapar²,

Demirci³

et al. 2020

KBB ve BBC Dergisi

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Ses kısıklığına en sık sebep olan durumlar vokal kordlara yerleşik, epitelyal veya midmembranöz malign yapıda olmayan patolojilerdir. Bu lezyonlara benign vokal kord lezyonları denir ve en sık olarak sırasıyla vokal kord nodülleri, polipleri ve reinke ödemi görülmektedir. 1 Vokal kord polipleri sesin aşırı ve kötü kullanımı, öksürük, sert boğaz temizleme gibi travmatik nedenlere bağlı olmakla birlikte; sigara, alkol, laringofaringeal reflü gibi toksik ve kimyasal faktörler de polip oluşumunda etkindir. Histopatolojik olarak, vokal kordlardaki hiyalüronik asit düzeyinin proteoglikanlara nazaran azalmasına yol açan patolojiler olup, vibratuar dinamikleri hafiften orta düzeye kadar etkileyen lezyonlardır. 2 Genellikle akut

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Efficacy of Intralesional Steroid Injection in Small Benign Vocal Fold Lesions

Cited by 10 publications

References 19 publications

Office-Based Steroid Injection in Benign Vocal Fold Lesions

Office-Based Steroid Injection in Benign Vocal Fold Lesions

Age‐dependent treatment effect of vocal fold steroid injection for benign vocal fold lesions

Objective Evaluation Regarding Efficacy of Endolaryngeal Microsurgery

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