Efficacy of intra-articular dexmedetomidine for postoperative analgesia in arthroscopic knee surgery

Abstract

Introduction Various drugs are administered intraarticularly to provide postoperative analgesia after arthroscopic knee surgery, of which opioids and alpha 2 agonists could be of particular interest. Methods Sixty patients undergoing elective knee arthroscopy were randomly assigned to two groups (n=30). Group R received 19 ml of 0.25% ropivacaine and 1 ml of isotonic saline (total volume 20 ml) intraarticularly. Group RD received 100 μg (1 ml) of dexmedetomidine added to 19 ml of 0.25% ropivacaine intra-articularly (total volume 20 ml). Analgesic effect was evaluated by measuring pain intensity (VAS score) and duration of analgesia. Results A longer delay was observed between intraarticular injection of study medication and first requirement of supplementary analgesic in group RD (10.84±2.6 hours) compared to group R (5.38±1.4 hours). Total consumption of fentanyl citrate in postoperative period was significantly less in group RD. No significant side effects were noted. Conclusion Dexmedetomidine, added as adjunct to ropivacaine in patients undergoing arthroscopic knee Departments of 1 Pharmacology, 2 Anaesthesiology and

Comparative Evaluation of Intra-articular Bupivacaine vs Intra-articular Bupivacaine and Dexmedetomidine for Postoperative Analgesia in Arthroscopic Knee Surgery

“…The significant finding in our study was the increased VAS scores (Table 4) and the increased use of tramadol (Table 5) in the control group (group BS) as compared with the study group (group BD), at time intervals of 30 minutes, 1 hour, and 2 hours. These findings are consistent with the previous studies by Paul et al 6 and…”

Dexmedetomidine in Current Anaesthesia Practice- A Review

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Knee Arthroplasty Surgery: Comparison of Intra-Articular Levobupivacaine and Dexmedetomidine with Ropivacaine and Dexmedetomidine for Post Operative Pain Management

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