Efficacy of intervention at traffic schools reducing impulsive action, and association with candidate gene variants

Luht, Kadi; Tokko, Tõnis; Eensoo, Diva; Vaht, Mariliis; Harro, Jaanus

doi:10.1017/neu.2019.2

Cited by 14 publications

(10 citation statements)

References 56 publications

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“…In our study disinhibition in 25-year-old women was correlated with high levels of total and LDL cholesterol in 15 years old girls. The gender differences may relate to the central serotonergic function, one of the possible mediators of serum lipid levels and impulsivity (Steegmans et al, 1996;Terao et al, 2000;Vevera et al, 2003;Luht et al, 2019). Serotonin pathways function as a behavioural restraint system that inhibits impulsive behaviour (Miyazaki et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…to action with less forethought than risk-free, but high Maladaptive impulsivity has high harm risk while Adaptive impulsivity supports success by agility. Previously, AMIS has been applied in a series of studies on risk-taking behaviour and impulsivity-related candidate genes studies, and found to have good predictive validity (e.g., Eensoo et al, 2004;Paaver et al, 2006;Laas et al, 2015a;Laas et al 2015b;Laas et al, 2017;Luht et al, 2019) At age 25, the Mini-International Neuropsychiatric Interview (MINI.5.0.0), (Sheehan et al, 1998) Estonian version (Shlik et al, 1999) Likert scale questions about misprize within the family and about emotional and physical abuse (Paaver et al, 2008;Kiive et al, 2010).…”

Section: Samplementioning

confidence: 99%

“…Previously, AMIS has been applied in a series of studies on risktaking behaviour and impulsivity-related candidate genes studies and found to have good predictive validity (e.g. Eensoo et al, 2004;Paaver et al, 2006;Laas et al, 2015aLaas et al, ,b, 2017Luht et al, 2019). Impulsivity data were available for 481 subjects at age 15 (Cohort 1 only, 260 females), 899 subjects at age 18 (509 females) and 935 subjects at age 25 (539 females).…”

Section: Behavioural Measuresmentioning

confidence: 99%

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Low cholesterol levels in children predict impulsivity in young adulthood

Tomson-Johanson

Kaart

Kiivet

et al. 2019

Acta Neuropsychiatr.

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AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Samplementioning

confidence: 99%

Section: Behavioural Measuresmentioning

confidence: 99%

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Low cholesterol levels in children predict impulsivity in young adulthood

Tomson-Johanson

Kaart

Kiivet

et al. 2019

Acta Neuropsychiatr.

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“…Being a 9R carrier has been associated with persistent ADHD in adults (Franke et al, 2012(Franke et al, , 2010. This genotype can also be associated with traffic risks: We have previously found that male 9R carriers had more accidents in traffic by their own fault (Tokko et al, 2019) and, in another sample, a higher general traffic risk (Luht et al, 2019).…”

Section: Introductionmentioning

confidence: 93%

Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism

Tokko

Miškinyte

Eensoo

et al. 2022

Nordic Journal of Psychiatry

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BackgroundRoad traffic injuries are a leading cause of death for young adults, and young drivers with higher expression of symptoms of attention deficit-hyperactivity disorder (ADHD) could pose an even greater risk in traffic. Dopaminergic dysfunction has been found to occur in ADHD, with the dopamine transporter (DAT) gene VNTR polymorphism (DAT1 VNTR; rs28363170) being one of the most consistent genetic markers. Thus, we aimed at clarifying how the ADHD symptoms and the DAT1 VNTR relate to risk-taking behaviour in traffic, impulsivity and driving anger in young drivers. MethodWe used data of two traffic behaviour study samples (n = 741, mean age = 23.3±7.2 years; n = 995, mean age = 22.9±8.1 years) and the Estonian Children Personality Behaviour and Health Study (ECPBHS; traffic behaviour data n = 1016, mean age = 25.2±2.1 years). ADHD symptoms were assessed by self-report with the Adult ADHD Self-Report Scale (ASRS v1.1) and impulsivity with the Adaptive and Maladaptive Impulsivity Scale. Traffic behavioural measures were either self-reported (Driver Behaviour Questionnaire, Driving Anger Scale) or obtained from databases (registered accidents and violations). ResultsDrivers with more self-reported ADHD symptoms also reported more risk-taking in traffic and had more of recorded traffic accidents and violations. DAT1 9R carriers had a higher probability of high traffic risk behaviour only if they also had ADHD symptoms. ConclusionHigher level of ADHD symptoms is a significant risk factor in traffic, and carrying of the DAT1 9R allele appears to aggravate these risks.

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“…Because AMIS combines items from the original Dickman’s impulsivity scale with NEO-PI-R items, the 2 primary dimensions of the questionnaire were named adaptive and maladaptive impulsivity to avoid confusion. Previously, AMIS scores were used to investigate driving and substance abuse: adaptive and maladaptive impulsivity scores were associated with risky driving and alcohol abuse in nationally representative samples of car drivers ( Eensoo et al, 2004 ; Paaver et al, 2006 ; Luht et al, 2019 ) and in a cross-sectional analysis on the ECPBHS ( Laas et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Association of Impulsivity With Food, Nutrients, and Fitness in a Longitudinal Birth Cohort Study

Matrov

Kurrikoff

Villa

et al. 2022

International Journal of Neuropsychopharmacology

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Background Impulsivity is a psychiatric vulnerability factor strongly associated with substance abuse but also with unhealthy diet. Whether these associations extend to specific nutrients is largely unknown. Therefore, we investigated the longitudinal association between diet, cardiorespiratory fitness, and two impulsivity dimensions in a representative sample of south Estonian adolescents and young adults. Impulsivity and dietary intake were measured three times in two birth cohorts at regular intervals in subjects of ages 15 to 33 years. Methods The sample included two birth cohorts of the longitudinal Estonian Children Personality Behaviour and Health Study (ECPBHS). The analytic sample size consisted of 2883 observations (56.4% females). The primary outcomes were adaptive and maladaptive impulsivity scores measured by an original 24 item Likert-type questionnaire. Impulsivity scores were predicted from the food diaries data converted into nutrient categories. Linear mixed-effects approach was used to model the time-dependence between observations. Results Lower maladaptive impulsivity was associated with higher cardiorespiratory fitness (β = -0.07; 95% CI: -0.12; -0.03). Higher maladaptive impulsivity was associated with lower dietary intake of zinc (β = -0.10; -0.15; -0.06) and vegetables (β = -0.04; -0.07; -0.01) and higher intake of sodium (β = 0.06; 0.02; 0.10). Vitamin B6 was positively associated with adaptive impulsivity (β = 0.04; 0.01; 0.07). Additionally, some of the adjusted models showed significant, but weak associations with selenium, alcohol, fish, and cereal products. Conclusions Food choice may affect the neurochemistry and therefore regulate the manifestations of impulsivity. We identified associations between several (micro)nutrients and maladaptive impulsivity.

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Efficacy of intervention at traffic schools reducing impulsive action, and association with candidate gene variants

Cited by 14 publications

References 56 publications

Low cholesterol levels in children predict impulsivity in young adulthood

Low cholesterol levels in children predict impulsivity in young adulthood

Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism

Association of Impulsivity With Food, Nutrients, and Fitness in a Longitudinal Birth Cohort Study

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