Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection

Abstract

The response of IFN monotherapy is better in patients aged < or =35 years than in older patients, probably because of mild stage histology, the effect of host-related factors, and shorter period of infection. Long-term IFN monotherapy may be suitable for young women who desire to become pregnant or those with anemia.

Dose comparison study of pegylated interferon‐α‐2b plus ribavirin in naïve Japanese patients with hepatitis C virus genotype 2: A randomized clinical trial

“…The multivariate analysis showed that SVR was dependent on the age of the patient and the dose of PEG‐I. Other studies reported a higher SVR rate for young patients than older patients 28–30 . Interestingly, the dose of PEG‐I was a significant and independent predictor of SVR.…”

“…Other studies reported a higher SVR rate for young patients than older patients. [28][29][30] Interestingly, the dose of PEG-I was a significant and independent predictor of SVR. Furthermore, other studies reported that no or mild hepatocyte steatosis was a significant factor associated with SVR.…”