Efficacy of Interferon for Chronic Hepatitis C Virus–Related Hepatitis in Kidney Transplant Candidates on Hemodialysis: Results After Transplantation

Casanovas-Taltavull, Teresa; Baliellas, Carme; Benasco, C; Serrano, Teresa; Casanova, Aurora; Pérez, José Luís; Guerrero, Lourdes; González, Teresa M; Andrès, Emmanuel; Gil-Vernet, S.; Casais, L

doi:10.1111/j.1572-0241.2001.03697.x

Cited by 29 publications

(23 citation statements)

References 29 publications

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“…Treatment was continued for at least 6 months, if the patient became negative for HCV RNA and normalized the liver transaminases. Patients treated with this regimen achieved sustained virological response in 20–64% of cases [31, 32, 33, 34], data which are comparable with immune competent patients. Other modified treatment protocols included daily interferon dosages with 3 MU for 2 months, and if tolerated followed by 3 × 3 MU interferon-α/week for a total of 12 months [35].…”

Section: Introductionmentioning

confidence: 50%

Clinical Impact of Hepatitis C Virus Infection in the Renal Transplant Recipient

Kallinowski¹,

Hergesell

Zeier

2002

Nephron

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Section: Introductionmentioning

confidence: 50%

Clinical Impact of Hepatitis C Virus Infection in the Renal Transplant Recipient

Kallinowski¹,

Hergesell

Zeier

2002

Nephron

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“…Discontinuation of the drug resulted in disappearance of the side effects in all patients. Higher rates of side effects and intolerance have been reported among HD patients [12, 13, 15, 16]. In all of these reports, however, the drug was given for a period of 12 months.…”

Section: Discussionmentioning

confidence: 92%

Interferon Therapy in Hemodialysis Patients with Chronic Hepatitis C: Study of Tolerance, Efficacy and Post-Transplantation Course

Mahmoud¹,

Sobh²,

Elhabashi³

et al. 2005

Nephron Clin Pract

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Background: The potential benefit of pre-transplant treatment of chronic hepatitis C on long-term evolution after renal transplantation is not clear. Methods: Fifty successive renal transplant candidates had their sera positive for HCV RNA and a biopsy-proven chronic hepatitis. Out of these, 18 patients received a standard course of interferon-α_2b (IFN; 3 MU three times weekly after hemodialysis sessions for 6 months). Results: IFN was discontinued in 2 patients (11%) due to persistent leukopenia. HCV RNA turned negative in 10 patients of the treatment group and in none of the control group. Two patients of the IFN group had a virological relapse post-transplantation. Post-transplant follow-up periods were 41.5 ± 15 and 50 ± 16 months for the treated and control groups respectively. Transaminases remained normal in all patients of the IFN group after transplantation. In contrast, biochemical evidence of acute and chronic hepatitis was observed in 5 (p = 0.03) and 13 (p = 0.002) patients, respectively, of the control group. Logistic regression analysis identified non-receiving IFN before transplantation as a risk factor for post-transplant hepatic dysfunction (odds ratio = 11.7, p = 0.003) and for chronic allograft nephropathy (odds ratio = 11.6, p = 0.02). Conclusions: IFN-treated patients had a significantly better post-transplant hepatic function and significantly lower rates of chronic allograft nephropathy.

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“…SVRs occurred in 64.2% [17]. Renal transplantation was subsequently performed in 14 patients, of whom 12 had excellent long-term graft function, one had acute vascular rejection and returned to hemodialysis, and one had fatal gastric carcinoma.…”

Section: Ifn-based Therapy In Patients On Dialysis Prior To Renal Tramentioning

confidence: 97%

Treatment of HCV infection in patients with renal failure

Bunnapradist

Fabrizi²,

Martin³

2006

Curr hepatitis rep

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Efficacy of Interferon for Chronic Hepatitis C Virus–Related Hepatitis in Kidney Transplant Candidates on Hemodialysis: Results After Transplantation

Abstract: Treatment results in our study population were better than those observed in the general population. The long-term response achieved, which was maintained after transplantation, supports the use of IFN for HCV hepatitis in kidney transplant candidates under hemodialysis.

Cited by 29 publications

References 29 publications

Clinical Impact of Hepatitis C Virus Infection in the Renal Transplant Recipient

Clinical Impact of Hepatitis C Virus Infection in the Renal Transplant Recipient

Interferon Therapy in Hemodialysis Patients with Chronic Hepatitis C: Study of Tolerance, Efficacy and Post-Transplantation Course

Treatment of HCV infection in patients with renal failure

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