Efficacy of integrated traditional Chinese medicine and Western medicine in the treatment of poststroke insomnia

Abstract

Background: Western medicine has played an essential role in treating poststroke insomnia (PSI) in China, and traditional Chinese medicine therapy based on Chinese characteristics is also effective. Combined with China's national conditions, we plan to conduct this systematic review and meta-analysis to compare the efficacy of integrated traditional Chinese medicine and Western medicine (INTEGRATED TCM and WM) therapy and Western medicine alone for PSI. Methods: We will search the following 5 electronic databases: PubMed, Wanfang, Chinese biomedical literature database, the Chongqing VIP Chinese Science and Technology Periodical, and China national knowledge infrastructure. Randomized controlled trials that compared the efficacy of INTEGRATED TCM and WM with Western medicine alone in the treatment of PSI will be considered. Primary outcomes have Treatment effectiveness rate, and Pittsburgh sleep quality index. Secondary outcomes include traditional Chinese medicine syndrome score, Athens insomnia scale, the incidence of adverse reactions, and outcome follow-up. Based on the eligibility criteria, we will conduct literature screening and data extraction. The quality of the included literature will be evaluated using the Cochrane risk of bias tools. We will use Review Manager software (Version 5.3) for data synthesis and statistical analyses. If sources of heterogeneity exist, we will perform a subgroup analysis or sensitivity analysis. A funnel plot will be used to analyze publication bias. Results: This study will provide evidence-based medicine evidence for treatment of PSI with INTEGRATED TCM and WM in terms of its efficacy. Conclusion: This systematic review aims to provide new options for INTEGRATED TCM and WM treatment of PSI in terms of its efficacy.

Systematic review: Pharmacological interventions for the treatment of post-stroke fatigue

“…We retrieved 33,297 citations, obtained full texts for 123 publications, and excluded 96 studies after full-text screening, including 35 RCTs that did not have a placebo. We included a total of 27 publications published in English or Chinese (10 published completed trials enrolling 616 participants, 14 – 23 5 publications of secondary analysis of the MIDAS (Modafinil in Debilitating Fatigue After Stroke) trial, 24 – 28 6 completed but not published trials, 29 – 34 and 6 ongoing trials). 35 – 40 All trials found were written in English or Chinese, except for 7 trials registered on the EU Clinical Trial Register in other languages; we screened and applied our inclusion criteria to these trials because English versions were available in the protocols.…”

“…Six randomized placebo-controlled trials have been completed (386 participants), but not yet published, [29][30][31][32][33][34] including three trials on Buyang Huanwu decoction (also known as Peiyuan huanwu decoction), 30,33,34 two on OSU6162, 16,29 and one on Perispinal Etanercept. 31 A further six ongoing randomized placebo-controlled trials were identified, including four Chinese herbal medicine trials (proposed sample size 112, 180, 400, and 432), a modafinil (proposed sample size 300), and a trial of BP1.3656 (histamine H3 receptor antagonist) intervention (proposed sample size 54).…”

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

“…However, long-term use is easy to produce drug resistance and adverse reactions, and patients' compliance is poor. [5,6] Currently, traditional Chinese medicine has become increasingly prominent for insomnia because of its stable curative effect and small side effects. [7] Traditional Chinese medicine believes that the pathogenesis of climacteric insomnia is Yang exuberance With Yin debilitation, Yang exuberance cannot enter Yin, Yin debilitation cannot receive Yang.…”

“…However, long-term use is easy to produce drug resistance and adverse reactions, and patients’ compliance is poor. [5,6]…”