Efficacy of injections of botulinum toxin-A for improving drooling and quality of life in disabled patients

Beranger, Thibaut; Piérache, Adeline; Loffer, Zoé; Tiffreau, V.; Ferri, Joël; Nicot, Romain

doi:10.1016/j.rehab.2019.11.004

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…BoNTs also demonstrate efficacy in modulating the hyperfunction of certain excretory glands by inhibiting the release of acetylcholine from nerve endings. At the neuromuscular junction, BoNTs induce muscle tone loss, and in glandular tissues, they inhibit cholinergic sympathetic nerve function [ 12 ]. The analgesic effects of BoNTs, though not fully explained, are thought to occur through multiple mechanisms.…”

Section: Mechanisms Of Action Of Bontsmentioning

confidence: 99%

Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications

Zhantleuova,

Leese,

Andreou

et al. 2024

Toxins

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This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT, offer an alternative for patients who face limitations in using paralytic forms of botulinum neurotoxin due to concerns about muscle function loss. We highlight the research findings that confirm not only the effectiveness of these molecules but also their reduced paralytic effect. We also discuss a potential cause for the diminished paralytic action of these molecules, specifically changes in the spatial parameters of the new botulinum molecules. In summary, this article reviews the current research that enhances our understanding of the application of new botulinum neurotoxins in the context of common conditions and suggests new avenues for developing more efficient molecules.

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Section: Mechanisms Of Action Of Bontsmentioning

confidence: 99%