Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study

Hersant, Barbara; SidAhmed-Mezi, Mounia; Belkacémi, Yazid; Darmon, Franklin; Bastuji‐Garin, Sylvie; Werkoff, G.; Bosc, Romain; Niddam, Jérémy; Hermeziu, Oana; Padula, Simone La; Meningaud, Jean Paul

doi:10.1097/gme.0000000000001122

Cited by 54 publications

(40 citation statements)

References 29 publications

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“…In 2018 a phase 2 pilot study was conducted to investigate the efficacy of autologous platelet-rich plasma combined with hyaluronic acid for the treatment of VVA in 20 postmenopausal women with a history of breast cancer [87]. All participants showed an improvement in vaginal dryness and dyspareunia, as expressed by the VHI (vaginal health index) score, after 6 months of treatment [87]. These results need to be confirmed.…”

Section: Treatment Options For Menopause—related Sexual Dysfunctionsmentioning

confidence: 99%

Sexual Health in Menopause

et al. 2019

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Sexual function worsens with advancing menopause status. The most frequently reported symptoms include low sexual desire (40-55%), poor lubrication (25-30%) and dyspareunia (12-45%), one of the complications of genitourinary syndrome of menopause (GSM). Declining levels of sex steroids (estrogens and androgens) play a major role in the impairment of sexual response; however, psychological and relational changes related with aging and an increase in metabolic and cardiovascular comorbidities should also be taken into account. Although first-line therapeutic strategies for menopause-related sexual dysfunction aim at addressing modifiable factors, many hormonal and non-hormonal, local and systemic treatment options are currently available. Treatment should be individualized, taking into account the severity of symptoms, potential adverse effects and personal preferences.

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Section: Treatment Options For Menopause—related Sexual Dysfunctionsmentioning

confidence: 99%

Sexual Health in Menopause

et al. 2019

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“…The regenerative potential of platelet-rich products has also been tested in tympanic perforation (51,52), skin lesions (53) -such as skin ulcers of multifactorial etiology: diabetic foot (54-56), pressure ulcers (57,58), venous ulcers (59) and even leprosy ulcers (60)-, vitiligo (61) and androgenetic alopecia (62). In the area of gynecology there are reports of the use of PRP to aid wound healing and recovery in caesarean delivery, vulvovaginal atrophy, benign cervical ectopy and it has also been applied in reproductive medicine and erectile dysfunction (63)(64)(65)(66)(67)(68)(69).…”

Section: Clinical Uses Of Platelet-derived Bio-products and Concerns:mentioning

confidence: 99%

Platelet-derived bio-products: Classification update, applications, concerns and new perspectives

Acebes-Huerta

Arias-Fernández

Bernardo

et al. 2020

Transfusion and Apheresis Science

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Platelet derived bio-products in the form of platelet rich plasma, plasma rich in growth factors, or plasma-free platelet releasates, are being studied worldwide with the aim of proving their efficacy in tissue regeneration within many different clinical areas, such as traumatology, maxillofacial surgery, ophthalmology, dermatology and otorhinolaryngology, amongst others. The current lack of consensus in the preparation method and application form, or in the quality assessment of each bio-product, precludes adequate interpretation of the relevance of reported clinical outcomes, and while many clinicians are very positive about them, as many are sceptic. Relevant aspects of these products are considered to propose a classification nomenclature, which would aid at the comprehensive comparison of clinical outcomes of bio-products of the same characteristics. Finally, the uses of platelet-derived bio-products in in vitro culture (for cell therapy purposes) as a substitute of animal-origin sera, and other future perspectives of applications of platelet-derived bio-products are discussed.

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“…Nach Studiendaten haben ca. 70 % der Frauen entsprechende Probleme [14]. Wegen der unklaren Datenlage ist eine Hormonersatztherapie bei Frauen nach Brustkrebs nicht empfohlen.…”

Section: Folgen Der Therapie Bei Gynäkologischen Tumorenunclassified

Endokrine Folgen einer Tumortherapie

Merz¹

2020

TumorDiagn u Ther

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Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study

Abstract: The injection of A-PRP-HA appeared to be a promising method to improve the trophicity and hydration of vaginal mucosa for the treatment of VVA in postmenopausal breast cancer survivors with contraindications to hormone therapy.

Cited by 54 publications

References 29 publications

Sexual Health in Menopause

Sexual Health in Menopause

Platelet-derived bio-products: Classification update, applications, concerns and new perspectives

Endokrine Folgen einer Tumortherapie

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