Efficacy of Influenza Vaccine in Elderly Persons in Welfare Nursing Homes: Reduction in Risks of Mortality and Morbidity During an Influenza A (H3N2) Epidemic

Deguchi, Yasuo; Nishimura, Kazutoshi

doi:10.1093/gerona/56.6.m391

Cited by 25 publications

(9 citation statements)

References 12 publications

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“…For seasonal influenza, three studies assessed vaccine efficacy in the general population [67]–[69], eight studies in children [68], [70]–[76], four studies in elderly populations [68], [77]–[79], two in health care workers [80], [81] and one in immunocompromised haemodialysis patients [82].…”

Section: Resultsmentioning

confidence: 99%

“…Four studies evaluated adverse events associated with seasonal influenza vaccines; one was conducted in children [76], one in health care workers [104], one in the general population [68] and two in the elderly [68], [77]. Pandemic A(H1N1)pdm09 vaccines were assessed for their safety in the general population [83], [105], in health care workers [106] and in children [90].…”

Section: Resultsmentioning

confidence: 99%

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A Review of the Evidence to Support Influenza Vaccine Introduction in Countries and Areas of WHO's Western Pacific Region

2013

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BackgroundImmunization against influenza is considered an essential public health intervention to control both seasonal epidemics and pandemic influenza. According to the World Health Organization (WHO), there are five key policy and three key programmatic issues that decision-makers should consider before introducing a vaccine. These are (a) public health priority, (b) disease burden, (c) efficacy, quality and safety of the vaccine, (d) other inventions, (e) economic and financial issues, (f) vaccine presentation, (g) supply availability and (h) programmatic strength. We analyzed the body of evidence currently available on these eight issues in the WHO Western Pacific Region.Methodology/Principal FindingsStudies indexed in PubMed and published in English between 1 January 2000 and 31 December 2010 from the 37 countries and areas of the Western Pacific Region were screened for keywords pertaining to the five policy and three programmatic issues. Studies were grouped according to country income level and vaccine target group. There were 133 articles that met the selection criteria, with most (90%) coming from high-income countries. Disease burden (n = 34), vaccine efficacy, quality and safety (n = 27) and public health priority (n = 27) were most frequently addressed by studies conducted in the Region. Many studies assessed influenza vaccine policy and programmatic issues in the general population (42%), in the elderly (24%) and in children (17%). Few studies (2%) addressed the eight issues relating to pregnant women.Conclusions/SignificanceThe evidence for vaccine introduction in countries and areas in this Region remains limited, particularly in low- and middle-income countries that do not currently have influenza vaccination programmes. Surveillance activities and specialized studies can be used to assess the eight issues including disease burden among vaccine target groups and the cost-effectiveness of influenza vaccine. Multi-country studies should be considered to maximize resource utilization for cross-cutting issues such as vaccine presentation and other inventions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Review of the Evidence to Support Influenza Vaccine Introduction in Countries and Areas of WHO's Western Pacific Region

2013

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“…10, 11 The latter are usually categorized by the International Classification of Diseases, Ninth Revision (ICD-9) codes. Although specific, these codes fail to adequately describe the significant heterogeneity that exists in the clinical presentation and outcomes of geriatric patients with influenza-related complications.…”

Section: Introductionmentioning

confidence: 99%

Effect of Influenza on Functional Decline

Gozalo¹,

Pop-Vicas²,

Feng³

et al. 2012

J American Geriatrics Society

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Objectives To examine the relationship between influenza and activity of daily living (ADL) decline and other clinical indicators in nursing home (NH) residents. Design Retrospective NH‐aggregated longitudinal study. Setting Two thousand three hundred fifty‐one NHs in 122 U.S. cities from 1999 to 2005. Participants Long‐stay (>90 days) NH residents. Measurements Quarterly city‐level influenza mortality and state‐level influenza severity. Quarterly incidence of Minimum Data Set–derived ADL decline (≥4 points), weight loss, new or worsening pressure ulcers (PUs), and infections. Outcome variables chosen as clinical controls were antipsychotic use, restraint use, and persistent pain. Results City‐level influenza mortality and state‐level influenza severity were associated with higher rates of large (≥4 points) ADL decline (mortality β = 0.20, P < .001; severity β = 0.18, P < .001), weight loss (β = 0.19, P < .001; β = 0.24, P < .001), worsening PUs (β = 0.04, P = .08; β = 0.12, P < .001), and infections (β = 0.41, P < .001; β = 0.47, P < .001) but not with restraint use, antipsychotic use, or persistent pain. NH influenza vaccination rates were weakly associated with the outcomes (e.g., β = −0.009, P = .03 for ADL decline, β = 0.008, P = .07 for infections). Compared with the summer quarter of lowest influenza activity, the results for the other quarters translate to an additional 12,284 NH residents experiencing large ADL decline annually, 15,168 experiencing significant weight loss, 6,284 new or worsening PUs, and 29,753 experiencing infections due to influenza. Conclusion The results suggest a substantial and potentially costly effect of influenza on NH residents. The effect of influenza vaccination on preventing further ADL decline and other clinical outcomes in NH residents should be studied further.

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“…11 No Japão, uma pesquisa demonstrou a significativa redução de surtos institucionais após a vacinação contra influenza, com impacto na morbimortalidade. 20 Os resultados da análise múltipla mostram que eventuais reações adversas à vacinação independem do sexo, da faixa etária ou da presença de doença crônica.…”

Section: Discussionunclassified

Eventos adversos após vacinação contra influenza em população institucionalizada, Campinas-SP, Brasil, 2004

Duarte

Donalísio

2009

Epidemiol. Serv. Saúde

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ResumoDados sobre ocorrência de eventos adversos da vacina contra influenza em população institucionalizada são pouco conhecidos no Brasil. Este estudo visou identificar esses eventos em uma instituição asilar no Município de Campinas, Estado de São Paulo, Brasil, após a Campanha Nacional de Vacinação contra influenza de 2004. Realizou-se entrevista para relato de sintomas locais e gerais, com nexo temporal após a aplicação do imunobiológico, em moradores que consentiram em participar da pesquisa e apresentavam condições de se expressar. Registraram-se 14,3% dos indivíduos com um ou mais sintomas, sendo os sintomas locais os mais freqüentes (52,9%). Ajustou-se um modelo de regressão logística múltipla, tendo como variável dependente a ocorrência de pelo menos um evento adverso. Nenhuma variável se apresentou estatisticamente significativa, mostrando que eventuais reações adversas à vacinação não variam segundo sexo, faixa etária e presença de doenças crônicas. Os resultados reafirmam a pouca reatogenicidade da vacina contra influenza.Palavras-chave: influenza; vacina; população institucionalizada; evento adverso. Summary VVery little is known in Brazil about data on adverse effects of influenza vaccine in an institutionalized population. This study had the purpose of identifying these events in a nursing

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Efficacy of Influenza Vaccine in Elderly Persons in Welfare Nursing Homes: Reduction in Risks of Mortality and Morbidity During an Influenza A (H3N2) Epidemic

Abstract: This study provides an analysis of the clinical efficacy of influenza vaccination in a large cohort of nursing home residents in JAPAN: Annual influenza vaccine administration requires the attention of all nursing home attendants, physicians, and public health organizations.

Cited by 25 publications

References 12 publications

A Review of the Evidence to Support Influenza Vaccine Introduction in Countries and Areas of WHO's Western Pacific Region

A Review of the Evidence to Support Influenza Vaccine Introduction in Countries and Areas of WHO's Western Pacific Region

Effect of Influenza on Functional Decline

Eventos adversos após vacinação contra influenza em população institucionalizada, Campinas-SP, Brasil, 2004

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