Efficacy of individualized homeopathic medicines in intervening with the progression of pre-hypertension to hypertension: A double-blind, randomized, placebo-controlled trial

Dutta, Souvik; Ganguly, Shirshendu; Mukherjee, Shyamal Kumar; Ghosh, Priyanka; Hazra, Pallavi; Roy, Aniket Singha; Shaikh, Abdur Rahaman; Ali, Sk Swaif; Sadhukhan, Satarupa; Koley, Munmun; Saha, Subhranil

doi:10.1016/j.explore.2021.05.007

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Similar "dual effects" have also been observed in some other placebo-controlled RCTs in homeopathy. [28][29][30][31] Several single-arm studies have been conducted in homeopathy to evaluate its effects on AV. Neither the sample sizes nor the study designs were adequate to yield any clear conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Similar “dual effects” have also been observed in some other placebo-controlled RCTs in homeopathy. 28 29 30 31…”

Section: Discussionmentioning

confidence: 99%

“…Patients aged between 12 and 30 years, suffering from mild (Global Acne Grading System [GAGS], 1-18) to moderate (GAGS, [19][20][21][22][23][24][25][26][27][28][29][30] forms of AV (ICD-10-CM code: L70.0), 20 of either sex, literate in Bengali and consenting to participate, were eligible to be included. Exclusion criteria were patients with severe (GAGS, 31-38) to very severe (GAGS, 39 or higher) forms of AV, any uncontrolled systemic or psychiatric diseases or life-threatening illness (e.g., cancer, diabetes, epilepsy, severe asthma, ischemic heart diseases), a selfreported immuno-compromised state, pregnancy, puerperal and lactating women, subjects on hormonal contraceptives, steroids or non-steroidal anti-inflammatory drugs, those using oil-based cosmetics or undergoing…”

Section: Participantsmentioning

confidence: 99%

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Efficacy of Individualized Homeopathic Medicines in Treatment of Acne Vulgaris: A Double-Blind, Randomized, Placebo-Controlled Trial

et al. 2022

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Introduction Acne is estimated to affect 9.4% of the global population, making it the 8th most prevalent disease worldwide. Acne vulgaris (AV) is among the diseases that directly affect quality of life. This trial evaluated the efficacy of individualized homeopathic medicines (IHM) against placebo in AV. Methods In this double-blind, randomized, placebo-controlled trial conducted at the National Institute of Homoeopathy, India, 126 patients suffering from AV were randomized in a 1:1 ratio to receive either IHM (verum) in centesimal potencies or identical-looking placebo (control). The primary outcome measure was the Global Acne Grading System score; secondary outcomes were the Cardiff Acne Disability Index and Dermatology Life Quality Index questionnaires — all measured at baseline and 3 months after the intervention. Group differences and effect sizes (Cohen's d) were calculated on the intention-to-treat sample. Results Overall, improvements were greater in the IHM group than placebo, with small to medium effect sizes after 3 months of intervention; however, the inter-group differences were statistically non-significant. Sulphur (17.5%), Natrum muriaticum (15.1%), Calcarea phosphorica (14.3%), Pulsatilla nigricans (10.3%), and Antimonium crudum (7.1%) were the most frequently prescribed medicines; Pulsatilla nigricans, Tuberculinum bovinum and Natrum muriaticum were the most effective of those used. No harms, unintended effects, homeopathic aggravations or any serious adverse events were reported from either group. Conclusion There was non-significant direction of effect favoring homeopathy against placebo in the treatment of AV. Trial Registration: CTRI/2018/11/016248; UTN: U1111–1221–8164.

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Section: Discussionmentioning

confidence: 99%

“…Similar “dual effects” have also been observed in some other placebo-controlled RCTs in homeopathy. 28 29 30 31…”

Section: Discussionmentioning

confidence: 99%