Efficacy of <i>Monascus purpureus</i> Went rice on lowering lipid ratios in hypercholesterolemic patients

Huang, Chien Fang; li, Tsai Chung; Lin, Cheng Chieh; Liu, Chiu Shong; Shih, Hung Chang; Lai, Ming May

doi:10.1097/hjr.0b013e32801da137

Cited by 62 publications

(29 citation statements)

References 9 publications

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“…Efficacy was similar to that found in previous studies [19]. Red yeast rice had a tendency to lower TG levels but without significance, but it has no effect on HDL-C.…”

Section: Discussionsupporting

confidence: 89%

Relationship between Adiponectin and Leptin, and Blood Lipids in Hyperlipidemia Patients Treated with Red Yeast Rice

Lee

Jan²,

Yu³

et al. 2013

Complement Med Res

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Background: This study aimed to investigate the possible relationships between adiponectin and leptin, blood lipids such as total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) as well as other clinical biomarkers in hyperlipidemia patients treated with red yeast rice. Methods: 30 patients with primary hyperlipidemia were recruited, treated with red rice yeast capsules 600 mg twice a day for 8 weeks, and followed up for 4 weeks. The primary endpoint was the mean difference in LDL-C from baseline to week 8, while the secondary endpoints were the mean percentage changes from baseline of total cholesterol, TG, HDL-C, adiponectin, and leptin. Results: At week 8, the decrease in LDL-C and total cholesterol was -38.11 ± 30.90 mg/dl (p < 0.0001) and -44.54 ± 27.46 mg/dl (p < 0.0001), respectively, and the increase in adiponectin was 35.83 ± 67.85 μg/ml (p = 0.017) as compared to baseline. Adiponectin also correlated positively with HDL-C (r2 = 0.39; p = 0.001). Serum leptin correlated negatively with TG (r2 = 0.19; p = 0.035), and there was a trend of correlation between leptin and HDL-C, but this was not statistically significant (r2 = 0.16; p = 0.052). Conclusion: Red yeast rice can significantly increase adiponectin and can significantly lower LDL-C and total cholesterol levels. Adiponectin correlates positively with HDL-C while serum leptin correlates negatively with TG. Red yeast rice has a potentially protective effect in obesity-related and cardiovascular diseases.

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“…Efficacy was similar to that found in previous studies [19]. Red yeast rice had a tendency to lower TG levels but without significance, but it has no effect on HDL-C.…”

Section: Discussionsupporting

confidence: 89%

Relationship between Adiponectin and Leptin, and Blood Lipids in Hyperlipidemia Patients Treated with Red Yeast Rice

Lee

Jan²,

Yu³

et al. 2013

Complement Med Res

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“…Numerous clinical studies performed in hyperlipidemic subjects have shown a beneficial effect of RYR extract supplements [8] resulting in a decrease in plasma total cholesterol (TC), LDL-C and triacylglycerols (TG) [3,[9][10][11]. In some cases, an increase of high-density-lipoprotein cholesterol (HDL-C) was also demonstrated [12].…”

Section: Introductionmentioning

confidence: 99%

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

et al. 2012

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“…In the former case, monacolin K was found to inhibit cholesterol synthesis and thus, to reduce hypolipidemia (Chairote et al, 2008;Lee et al, 2007). Previous studies showed that Monascus purpureus significantly reduced the low density lipoproteincholesterol (LDL-C), total cholesterol, triglycerides, and apolipoprotein B levels, and was well tolerated in patients with hyperlipidemia (Huang et al, 2007;Lin et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Growth Performance and Meat Quality of Broiler Chicks Fed Germinated and Fermented Soybeans

Lee¹,

Shin²,

Park³

et al. 2010

Korean Journal for Food Science of Animal Resources

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This study was conducted to investigate the dietary effects of germinated and fermented (with Monascus pupureus) soybean screenings (GFS) on growth performance and meat quality in broiler chicken. A total of 750 1-day-old Ross × Ross male broiler chicks were randomly allocated into five groups (five replications with 30 birds each) and fed experimental diets for 5 wks as follows: Group 1, negative-control (antibiotics-free diet); Group 2, positive-control (negative-control with 10 ppm of Avilamycin); Group 3, negative-control with 0.3% GFS; Group 4, negative-control with 0.5% GFS; Group 5, negative-control with 1% GFS. The final body weight of each group fed a diet containing 1% GFS was significantly higher than that of the negative-control group. The feed conversion ratios of all groups fed diets containing GFS and the positivecontrol group were significantly improved compared to the negative-control group during the whole period (p<0.05). The relative weights of various organs along with the activities of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) were not influenced by the dietary treatments. The levels of total serum cholesterol in groups fed diets containing 0.5% and 1% GFS were more significantly lowered compared to those of the control groups without GFS (p<0.05). There were no significant differences in the cecal microflora profiles among the groups. Further, the dietary treatments did not influence the physico-chemical properties of the edible meat, including the shear force, pH, meat color (CIE L*, a* and b*), and content of malondialdehyde (MDA). Cooking loss of breast muscle in the groups fed GFS was significantly lowered compared to that of the negative control group (p<0.05). These results indicate that dietary GFS could improve growth performance in broiler chicken and may affect meat quality in some instances.

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Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients

Abstract: Red yeast rice can reduce lipid ratios in hypercholesterolemic patients.

Cited by 62 publications

References 9 publications

Relationship between Adiponectin and Leptin, and Blood Lipids in Hyperlipidemia Patients Treated with Red Yeast Rice

Relationship between Adiponectin and Leptin, and Blood Lipids in Hyperlipidemia Patients Treated with Red Yeast Rice

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

Growth Performance and Meat Quality of Broiler Chicks Fed Germinated and Fermented Soybeans

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