Efficacy of hyoscine‐N‐butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour

Abstract

Hyoscine-N-butyl bromide (HBB, Buscopan) suppositories were highly effective in shortening the duration of the first stage of labour.

Role of hyoscine N-butyl bromide (HBB, buscopan®) as labor analgesic

“…That HBB can be used as a cervical spasmolytic has been evaluated in many studies, [3,4,[6][7][8][9] and the results corroborated with our study. Bhattacharya et al, [4] studied the effect of 20 mg HBB intramuscularly on 100 primigravidas and found that mean labor time was shortened by 3 hours 40 minutes and 81% delivered within 8 hours.…”

“…[9] The advantages of intravenous route in a controlled manner (slow i/v over 1-2 minutes) are its rapid onset of action and bypass of hepatic metabolism. The rectal route is also popular [8] for this reason.…”

“…[5] Many studies [3,4,[6][7][8][9] have been carried out to evaluate the effects of HBB in the active management of labor, but no studies have evaluated its role as a labor analgesic. Most of these studies have been with the intramuscular route, [3,4,6] a few isolated studies using the intravenous [7,9] and suppository routes [8] but none with a dose of 40 mg as a single dose.…”

To compare the efficacy of drotaverine hydrochloride with hyoscine butylbroumide for increasing the rate of cervical dilatation

“…Chan et al did not find an impact of hyoscine butylbromide on the duration of first stage of labour whereas Sirohiwal et al have found that hyoscine N-butyl bromide suppositories have a significant reducing effect on the first stage of labour. 21,22 Samuels et al too showed a similar reducing effect of hyoscine butylbromide on the mean duration of first stage of labour against a placebo. 23 Raghavan et al in a comparative assessment of hyoscine butyl-bromide with valethamate bromide against a placebo showed a significantly better efficacy in both the test groups in acceleration of first stage of labour.…”

A comparative study of the effect of drotaverine hydrochloride with hyoscine butylbromide in first stage of labor

“…In different studies hyoscine butylbromide and drotaverine hydrochloride have independently shown controversial results Chan et al 11 did not find an impact of hyoscine butylbromide on the duration of first stage of labor whereas Sirohiwal et al 12 have found that hyoscine N-butylbromide suppositories have a significant reducing effect on first stage of labor. Samuels et al 13 too showed a similar reducing effect of hyoscine butylbromide on the mean duration of first stage of labor against a labor.…”