Efficacy of hyaluronic acid in rotator cuff pathology compared to other available treatment modalities: A Systematic Review and meta-analysis

Bansal, Shivam; Raja, Balgovind S.; Niraula, Bishwa Bandhu; Regmi, Anil; Choudhury, Arghya Kundu; Sharma, Divyansh; Dhingra, Mohit

doi:10.1016/j.jorep.2023.100157

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Their study did not have a 3-month follow-up point, but the median improvement percentage between the initial visit and their 6-month follow for the PRP group and CS group was approximately 27% and 32%, respectively, for WORC, and 30% and 34%, respectively, for VAS. A systematic review and meta-analysis by Bansal in 2023 compared hyaluronic acid (HA) injections to PRP, CS, and placebo groups from 18 randomized control trials (RCTs) [9]. They found that there was significant improvement (p < 0.05) in VAS and constant Murphy score when comparing HA with physical therapy and PRP on short-term follow-up (1 and 3 months), with insignificant results on comparing HA with placebo (normal saline) and steroids.…”

Section: Discussionmentioning

confidence: 99%

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Safety and Efficacy of Wharton’s Jelly Connective Tissue Allograft for Rotator Cuff Tears: Findings from a Retrospective Observational Study

Lai,

Tamea,

Shou

et al. 2024

Biomedicines

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With the increasing occurrence of rotator cuff injuries every year, there is a great need for a reliable treatment option. Wharton’s Jelly contains several components that can positively impact the replacement and repair of musculoskeletal defects. The overall objective of this study is to evaluate the improvement of patient-reported pain scales after applying Wharton’s Jelly (WJ) in rotator cuff defects. Eighty-seven patients with rotator cuff defects who failed at least eight weeks of conservative treatment were selected from the retrospective repository. A total of 2 cc of WJ flowable allograft was applied to the specific affected anatomy, the most common being supraspinatus tendon, biceps tendon insertion, labral tear, and subscapularis tear. No adverse reactions were reported. Statistically significant improvements were found from the initial to Day 90 in all scales. Patient satisfaction was calculated using minimal clinically important differences. No statistically significant differences were found in mean changes between gender, BMI, and age. Scanning electron microscopy images reveal the similarities between the collagen matrix in WJ and the rotator cuff. The significant improvement in patient outcomes coincides with the current literature analyzing WJ applications with other structural defects around the body. WJ is a promising alternative for musculoskeletal defects when the standard of care fails.

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Section: Discussionmentioning

confidence: 99%

“…The most common nonsurgical treatment plans include NSAIDS, physical therapy, and injections. The most common injections include platelet-rich plasma (PRP) and hyaluronic acid (HA) [8,9]. These modalities can also be accompanied by extracorporeal shockwave therapy (ESWT) to increase hypervascularity [10].…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Wharton’s Jelly Connective Tissue Allograft for Rotator Cuff Tears: Findings from a Retrospective Observational Study

Lai,

Tamea,

Shou

et al. 2024

Biomedicines

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Injections of Anatomical Regions and Diseases: Shoulder

Fabrizio,

Dario,

Lorenzo

et al. 2024

Musculoskeletal Injections Manual

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A Retrospective Study of Wharton’s Jelly Tissue Allografts for Rotator Cuff Defect Applications

Lai,

Tamea,

Shou

et al. 2024

Preprint

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With the increasing occurrence of rotator cuff injuries every year, there is a great need for a reliable treatment option. Wharton’s Jelly contains several components that can positively impact the replacement and repair of musculoskeletal defects. The overall objective of this study is to evaluate the improvement of patient-reported pain scales after applying Wharton’s Jelly (WJ) in rotator cuff defects. Eighty-seven patients with rotator cuff defects who failed at least eight weeks of conservative treatment were selected from the retrospective repository. 2cc of WJ flowable allograft was applied to the specific affected anatomy, the most common being supraspinatus tendon, biceps tendon insertion, labral tear, and subscapularis tear. Patients were monitored for 30 minutes post-procedure. No adverse reactions were reported. Statistically significant improvements were found from initial to Day 90 for all pain scales used. No statistically significant differences were found in mean changes between gender, BMI, and age. Scanning Electron Microscopy images reveal the similarities between the collagen matrix in WJ and the rotator cuff. The significant improvement in patient outcomes coincides with current literature analyzing WJ applications with other structural defects around the body. WJ is a promising alternative for musculoskeletal defects when the standard of care fails.

show abstract

Efficacy of hyaluronic acid in rotator cuff pathology compared to other available treatment modalities: A Systematic Review and meta-analysis

Cited by 3 publications

References 53 publications

Safety and Efficacy of Wharton’s Jelly Connective Tissue Allograft for Rotator Cuff Tears: Findings from a Retrospective Observational Study

Safety and Efficacy of Wharton’s Jelly Connective Tissue Allograft for Rotator Cuff Tears: Findings from a Retrospective Observational Study

Injections of Anatomical Regions and Diseases: Shoulder

A Retrospective Study of Wharton’s Jelly Tissue Allografts for Rotator Cuff Defect Applications

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