Efficacy of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in treatment of COVID-19: A randomized controlled trial

Xiao, Mingzhong; Tian, Jiaxing; Zhou, Yue; Xu, Xi; Min, Xiaojun; Lv, Yi; Peng, Miao; Zhang, Ying; Yan, Dengying; Lang, Suping; Zhang, Qing; Fan, Ailong; Ke, Jia; Li, Xiuyang; Liu, Binbin; Jiang, Manhong; Liu, Quan; Zhu, Jinyue; Yang, Lei; Zhu, Zheng; Zeng, Kun; Li, Chengyin; Zheng, Yujiao; Wu, Haoran; Lin, Jiaran; Lian, Fengmei; Li, Xiaodong; Tong, Xiaolin

doi:10.1016/j.phrs.2020.105126

Cited by 164 publications

(222 citation statements)

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“…Currently, some commercial Chinese medicine preparations are also used in this epidemic. A randomized clinical trial evaluated the clinical efficacy of Huoxiang Zhengqi drop pills and/or Lianhua Qingwen granules combined with Western medicine in treating COVID-19 [ 245 ]. The results showed that Huoxiang Zhengqi drop pills combined with Lianhua Qingwen granules and Western medicine had advantages in improving nausea, vomiting, and sore limbs, as well as reducing the use of antibiotics.…”

Section: Understanding Covid-19 From the Perspective Of Tcmmentioning

confidence: 99%

A Comprehensive Summary of the Knowledge on COVID-19 Treatment

Peng¹,

Tao²,

Satyanarayanan³

et al. 2021

Aging and disease

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Section: Understanding Covid-19 From the Perspective Of Tcmmentioning

confidence: 99%

A Comprehensive Summary of the Knowledge on COVID-19 Treatment

Peng¹,

Tao²,

Satyanarayanan³

et al. 2021

Aging and disease

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“…In vitro: influenza virus A1/Qianfang/166/85 (H1N1) in A549 10, 5, 2.5, 1.25, 0.63 mg/ml Wang et al, 2008;Dong et al, 2015;Wang et al, 2016 In TNF-a, IP-10, and MCP-1, and also inhibits SARS-CoV-2 replication in Vero E6 cells and markedly reduced proinflammatory cytokines (TNF-a, IL-6, CCL-2/ MCP-1 and CXCL-10/IP-10) production at the mRNA levels. Zhu et al, 2003;Ding et al, 2017;Guan et al, 2018;Bao et al, 2019;Gao et al, 2020;Li R. F. et al, 2020;Xiao et al, 2020 In Prospective study: patients with severe acute respiratory syndrome (SARS) in the mild or severe stage. Prospective study: patients with severe acute respiratory 0.755 g/ml, 400 ml/day Glucocorticoid, ganciclovir, levofloxacin, and invigorate blood, boost qi and nourish yin, relieve cough and calm panting, Formula III for SARS during Convalescence (Feidian Huifuqi Sanhao Fang) with recovery to boost qi and nourish yin, fortify the spleen and harmonize the stomach.…”

Section: Granular Solutionmentioning

confidence: 99%

Role of Traditional Chinese Medicine in the Management of Viral Pneumonia

Yue

et al. 2020

Front. Pharmacol.

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Viral pneumonia is one kind of acute respiratory tract infection caused by the virus. There have been many outbreaks of viral pneumonia with high contagiousness and mortality both in China and abroad, such as the great influenza in 1918, the severe acute respiratory syndrome (SARS) coronavirus in 2003, the Influenza A (H1N1) virus in 2009, and the Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 2012 and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019. These outbreaks and/ or pandemic have significant impact on human life, social behaviors, and economic development. Moreover, no specific drug has been developed for these viruses. Traditional Chinese medicine (TCM) plays an important role in the treatment of viral pneumonia during these outbreaks especially in SARS and SARS-CoV-2 because studies suggest that TCM formulations may target several aspects of the disease and may have lesser side effects than manufactured pharmaceuticals. In recent years, a lot of clinicians and researchers have made a series of in-depth explorations and investigations on the treatment of viral pneumonia with TCM, which have understood TCM therapeutic mechanisms more specifically and clearly. But critical analysis of this research in addition to further studies are needed to assess the potential of TCM in the treatment of viral pneumonia.

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“…Hanshiyi Formula, a TCM prescription, can significantly reduce the progression to severe disease in patients with mild and moderate COVID-19, which may both prevent and treat the disease [5] . The use of Huoxiang Zhengqi Pill and Lianhua Qingwen Granule combined with Western medicine may have advantages for COVID-19 patients in improving clinical symptoms, reducing utilization rate of antibacterial and antiviral drugs, and improving patient prognosis [6] . Furthermore, TCM has shown rapid clinical improvements.…”

Section: Introductionmentioning

confidence: 99%