BackgroundChildren undergoing diagnostic and interventional radiology procedures often require sedation to achieve immobility and analgesia if the procedure is painful. In the past decades, leading scientific organizations have developed evidence‐based guidelines for procedural sedation and analgesia in children outside of the operating room. Their recommendations are being applied to procedural sedation in radiology. However, some questions remain open regarding specific aspects contextualized to the radiology setting, such as elective prone sedation, the urgency of the procedure, when venous access or airway protection is required, and others.AimsTo address the unresolved issues of procedural sedation and analgesia in pediatric diagnostic and interventional radiology.MethodsAn expert panel of pediatricians, pediatric anesthesiologists, intensivists, and neuroradiologists selected topics representative of current controversies and formulated research questions. Statements were developed by reviewing the literature for new evidence, comparing expertise and experience, and expressing opinions. Panelists' agreement with the statements was collected anonymously using the DELPHI method.ResultsTwelve evidence‐based or expert opinion incorporate are presented, considering risks, benefits, and applicability.ConclusionsThis consensus document, developed by a multidisciplinary panel of experts involved in the field, provides statements to improve the quality of decision‐making practice in procedural sedation and analgesia in pediatric radiology.