Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial

Llor, Carl; Pérez, A López; Carandell, Eugenia; García-Sangenís, Anna; Rezola, Javier; Llorente, Marian; Gestoso, Salvador; Bobé, Francesc; Román-Rodríguez, Miguel; Cots, Josep M.; Hernández, Sílvia; Martínez, Jordi; Miravitlles, Marc; Morros, Rosa

doi:10.1016/j.aprim.2017.08.003

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…An overview of the different studies included in this review [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ] is given in Table 1 . Two controlled trials and 17 randomized controlled trials were included.…”

Section: Resultsmentioning

confidence: 99%

“…One non-inferiority RCT was identified where phenoxymethylpenicillin was tested against amoxicillin for the treatment of community-acquired pneumonia [ 25 ]. Patients were recruited in primary care, and the diagnosis of pneumonia was radiologically confirmed.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in this review, only one clinical study has compared the two antibiotics. The study was performed in Spain, which has relatively high levels of penicillin-resistant S. pneumoniae [ 25 ]. Even though the study was heavily underpowered, significant differences in favour of amoxicillin were found in the intention-to-treat analysis.…”

Section: Discussionmentioning

confidence: 99%

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Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review

Skarpeid

Høye

2018

Antibiotics

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Most antibiotics are prescribed in primary care, and commonly for respiratory tract infections (RTIs). Narrow-spectrum phenoxymethylpenicillin is the antibiotic of choice for RTIs in the Scandinavian countries, while broader spectrum amoxicillin is used in most other European countries. This review summarizes the knowledge of the effect of phenoxymethylpenicillin versus amoxicillin for infections treated in ambulatory care. We searched PubMed/Medline and Embase for trials comparing the clinical effect of phenoxymethylpenicillin and amoxicillin. The Norwegian Knowledge Centre for the Health Services’ checklist was used to assess risk of bias. In total, 1687 studies were identified, and 18 of these fulfilled the inclusion criteria. One additional study was found as a reference. The randomized controlled trials revealed no significant differences in clinical effect in acute sinusitis (three RCTs), GAS tonsillitis (11 RCTs) and Lyme borreliosis (two RCTs). One RCT on community-acquired pneumonia found amoxicillin to be superior, while the results were conflicting in the two RCTs on acute otitis. The results suggest that non-Scandinavian countries should consider phenoxymethylpenicillin as the treatment of choice for RTIs because of its narrower spectrum. More studies should be conducted on the clinical effect of phenoxymethylpenicillin versus amoxicillin for acute otitis and lower RTIs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review

Skarpeid

Høye

2018

Antibiotics

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“…[ 6 – 8 , 29 ] Western medicine routine treatment is mainly based on antibiotics and antiviral drugs, such as penicillin, ceftriaxone sodium, amoxicillin, amoxicillin and clavulanate, erythromycin, azithromycin, minocycline, doxycycline, clarithromycin, levofloxacin, interferon, ribavirin, oseltamivir, ganciclovir, and so on. [ 12 – 25 ] There are many Western medicines used in clinical. Therefore, the systematic review assesses efficacy and safety of Reduning injection combined with Western medicine to treat pneumonia and provide evidence to clinicians.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 – 8 ] Western medicine routine treatment mainly uses antibiotics (penicillins, cephalosporins, macrolides, and aminoglycosides etc.) [ 12 – 21 ] and antiviral drugs (interferon and ribavirin). [ 22 – 25 ] However, the evaluation of their efficacy is not scientific and systematic.…”

Section: Introductionmentioning

confidence: 99%

Reduning injection combined with western medicine for pneumonia

Cao¹,

Zhen²,

Kuang³

et al. 2020

Medicine

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Background: Pneumonia is a common respiratory disease. In severe cases, it can induce cardiovascular disease and even life-threatening. In particular, pneumonia caused by the new coronavirus (SARS-CoV-2) that broke out at the end of 2019 has seriously affected the health of people in all countries. In recent years, it has been treated with the combination of traditional Chinese medicine (TCM) (such as Reduning injection) and Western medicine, and its mortality has decreased significantly. But their efficacy has not been scientifically and systematically assessed. Accordingly, it is essential to provide a systematized review program to estimate the efficacy and safety of Reduning injection combined with Western medicine to treat pneumonia. Methods: The following databases are retrieved from start to September 2020: Pubmed, Cochrane Library, EMBASE, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, the Chongqing VIP Chinese Science and Technology Periodical Database (VIP) databases, Chinese Biomedical Literature Database (CBM), and other databases, which are absorbed into clinical RCTs of pneumonia using western medicine alone or plus Reduning injections. The selection of studies, data extraction, and assessment of risk of bias will be performed independently by 2 reviewers. At the same time, Review Manager V.5.3.5 (Rev Man V.5.3.5) was used for bias risk assessment and data synthesis. Results: The efficacy and safety of Reduning injection combined with western medicine in the treatment of pneumonia were evaluated in terms of overall effective rate, the patient's antipyretic time, antitussive time, rales disappearing time, X-ray recovery time, and the incidence of adverse reactions. Conclusions: This study provides reliable evidence-based support for the clinical application of Reduning injection combined with western medicine for pneumonia. Ethics and dissemination: Ethical approval is not required in this secondary research evidence, and we will publish the results of this study in a journal or relevant conferences. Registration number: DOI 10.17605/OSF.IO/VS75Y.

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Identifying the Best Initial Oral Antibiotics for Adults with Community-Acquired Pneumonia: A Network Meta-Analysis

Kurotschka,

Bentivegna,

Hulme

et al. 2024

J GEN INTERN MED

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Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial

Abstract: There was a trend favoring high-dose amoxicillin versus high-dose penicillin in adults with uncomplicated CAP. The main limitation of this trial was the low statistical power due to the low number of patients included.

Cited by 7 publications

References 27 publications

Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review

Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review

Reduning injection combined with western medicine for pneumonia

Identifying the Best Initial Oral Antibiotics for Adults with Community-Acquired Pneumonia: A Network Meta-Analysis

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