Efficacy of High Dose Per Fraction Radiation for Implanted Human Prostate Cancer in a Nude Mouse Model

Abstract

SBRT dose level treatments were able to significantly decrease tumor volume and PSA. However, using 15 and 22.5 Gy durable responses were not achieved except in a few mice. The 45 Gy group demonstrated sustained PSA and tumor volume decreases in most mice. These results clearly show an increasing dose-response relationship for a range of hypofractionated dose levels, as used in SBRT.

alpha6 Integrin Cleavage: Sensitizing human prostate cancer to ionizing radiation

“…Several centers have initiated preliminary trials using higher doses per fraction, called aggressive hypo fractionation (Parker & Patrocinio 2005). Recent work has indicated that a high dose per fraction IR is efficacious for increasing tumor response rates of human prostate cancer implanted in a mouse (Lotan et al 2006). These studies underscore that human prostate cancer is both a radiation resistant tumor type and is capable of tumor repopulation following therapeutic doses of IR.…”

CyberKnife Stereotactic Radiotherapy as Monotherapy for Low- to Intermediate-Stage Prostate Cancer: Early Experience, Feasibility, and Tolerance

“…SBRT dose level treatments (fraction dose higher than 4 Gy) were able to significantly decrease tumor volume and PSA level in mice. 8 The efficacy of the HDR brachytherapy as monotherapy was established, encouraging the wide use of this accurate hypofractionated radiation delivery mechanism. [9][10][11] Several clinical series that used hypofractionated external beam regimens have also shown advantage for hypofractionation, with doses per fraction ranging from 2.5 to 3.1 Gy.…”

Celecoxib steigert die Strahlenempfindlichkeit von sekundären Knochentumoren eines nicht-kleinzelligen humanen Lungenkarzinoms durch Anti-Angiogenese in vivo

“…As the response rate of tumors to radiation seems to be dependent on the delivered dose, strategies increasing the effective dose of radiation may be crucial to ameliorate the therapeutic efficacy of radiotherapy [16,22,25,27,45,50]. Recent strategies to optimize the efficacy of radiation are focused on molecular targets enhancing the radiation sensitivity of malignant tumors [1,2,4,11,13,15,28,31,36,37,40,53].…”