Efficacy of Herbal and Naturally-Derived Dietary Supplements for the Management of Knee Osteoarthritis: A Mini-Review

Abstract

Knee osteoarthritis (OA) accounts for approximately 85% of the burden of OA worldwide. Knee OA is a whole joint disorder involving structural alterations in the hyaline articular cartilage, subchondral bone, ligaments, capsule, synovium, and periarticular muscles. The complex knee OA pathogenesis includes mechanical, inflammatory, and metabolic factors, eventually leading to the synovial joint’s structural destruction and failure. This review aims to present an overview of current knowledge on dietary supplements, such as glucosamine, chondroitin, methylsulfonylmethane, diacerein, avocado-soybean unsaponifiables, curcuminoids, as well as boswellic acids. Results originating from several small studies with natural products in managing knee OA are encouraging. However, additional well-designed placebo-controlled clinical trials are required.

Potential role of nutraceuticals via targeting a Wnt/β‐catenin and NF‐κB pathway in treatment of osteoarthritis

“…Besides that, neferine also has osteoporosis‐related effects, such as reducing bone loss while increasing bone growth. It seems that neferine, a potential OA medication, reduced IL‐1β‐induced overproduction of pro‐inflammatory and apoptotic factors in mouse chondrocytes by blocking the MAPK and NF‐κB pathways (Żęgota et al, 2021). A substance called coptisine, derived from the roots of Coptis rhizome , is an isoquinoline alkaloid.…”