Efficacy of hepatic T2* <scp>MRI</scp> values and serum ferritin concentration in predicting thalassemia major classification for hematopoietic stem cell transplantation

Hamidieh, Amir Ali; Tayebi, Sirous; Shamshiri, Ahmad Reza; Behfar, Maryam; Jalili, Mahdi; Ghavamzadeh, Ardeshir

doi:10.1111/petr.12428

Cited by 6 publications

(3 citation statements)

References 40 publications

(44 reference statements)

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“…Outcomes of HCT for β-thalassemia generally report on survival. However, late follow-up and long-term effects after HCT are scarce and limited to single centers and focused organs [15][16][17][18][19][20][21]. This international report on long-term followup after HCT for β-thalassemia was undertaken to evaluate late follow-up efforts and outcomes in patients surviving beyond 1-year post-HCT and compiles data obtained from 7 contributing centers.…”

Section: Introductionmentioning

confidence: 99%

A Multicenter Retrospective Analysis Stressing the Importance of Long-Term Follow-Up after Hematopoietic Cell Transplantation for β-Thalassemia

Chaudhury

Ayas

Rosen

et al. 2017

Biology of Blood and Marrow Transplantation

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Allogeneic hematopoietic cell transplantation (HCT) is curative in patients with β-thalassemia major. However, most reports on HCT outcomes lack long-term follow-up data with the exception of single-center reports. An international multicenter retrospective data collection and analysis was conducted in 176 β-thalassemia patients who were 1 year or beyond after first HCT to evaluate follow-up methods and outcomes at 7 centers. Median age at HCT was 5.5 years (range, .6 to 18.5), and median follow-up was 7 years (range, 1 to 20). HCT was predominantly from HLA-matched related donors (91%) with bone marrow as stem cell source (91%) and myeloablative conditioning regimens (88%). Late mortality or persistent chronic graft-versus-host disease (GVHD) was rare (<2%). Graft rejection was reported in 23% (24% of these occurred beyond 1 year) post-HCT. Of 119 patients with donor chimerism results available for ≥4 years post-HCT, 50% had >95%, 22% had 50% to 95%, 7% had 20% to 50% and 25 (21%) had <20% donor chimerism. Organ dysfunction was identified in 10% pre-HCT and in 20% post-HCT even without complete clinical details on all patients. Hypogonadism and elevated creatinine for age were most commonly reported and significantly higher in recipients ≥ 7 years at the time of HCT (P = .007) and in those with pre-existing morbidity before HCT (P = .02). Outcomes were unaffected by pre-HCT ferritin or GVHD. Mean z scores for height and weight were low at baseline and remained low post-HCT (79%), confirming that growth impairment from disease lacked recovery post-HCT during this follow-up period. HCT for β-thalassemia has a high rate of cure and low mortality, especially in the young and from HLA-matched related donors. Half of the number of recipients live with mixed chimerism that requires continued follow-up because of a risk of late graft rejection (14%). Organ function after HCT when <7 years of age was generally preserved. Hypogonadism, renal dysfunction, and growth impairment that failed to correct were late complications identified most frequently in older transplant recipients. Systematic follow-up of individual organs such as lung and heart were inadequate but important. These data support the development of simple measures of uniformly tracking long-term HCT outcomes and organ functions in children and adolescents who undergo HCT for thalassemia, allowing for systematic identification and implementation of standardized surveillance strategies and interventions.

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Section: Introductionmentioning

confidence: 99%

A Multicenter Retrospective Analysis Stressing the Importance of Long-Term Follow-Up after Hematopoietic Cell Transplantation for β-Thalassemia

Chaudhury

Ayas

Rosen

et al. 2017

Biology of Blood and Marrow Transplantation

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“…Liver biopsy is the gold standard; however, it carries the risks of the invasive procedure. Transient elastography (FibroScan) and T2 MRI have been shown to be reliable noninvasive methods to predict liver fibrosis secondary to iron overload, for TM patients who are candidates to HSCT (Hamidieh et al 2014;Hamidieh et al 2015).…”

Section: Best Transplant Candidatesmentioning

confidence: 99%

Hemoglobinopathies (Sickle Cell Disease and Thalassemia)

et al. 2018

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Sickle cell disease (SCD) is the most common inherited hemoglobinopathy worldwide. It results from a single-nucleotide substitution that leads to a propensity toward hemoglobin polymerization and sickling of red blood cells. Sickle cell disease is characterized by anemia, ongoing hemolysis, and acute and chronic vaso-occlusive complications affecting multiple organs. SCD affects over 100,000 Americans, and it occurs in about one in 500 African-American births and in one in every 1000-1400 Hispanic-American births (NIH 2014;Piel et al. 2013).The implementation of newborn screening, penicillin prophylaxis, vaccination programs, narcotics, chronic transfusions, hydroxyurea, and the early detection of cerebral vasculopathy with transcranial Doppler (TCD) have improved the perspective for children with SCD (Angelucci

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“…Huaqiao elaborated in the article that it will enter a recovery period after the exercise is stopped, and the serum ferritin concentration will return to the original level after a period of time, and pointed out the change rule of serum protein concentration during recovery [7]. Hamidieh pointed out that some anemia caused by exercise is mainly caused by the disturbance of ferritin metabolism, which makes it difficult for the continuous production of red blood cells, and analyzes the concurrent principle of anemia, which has important guiding significance for the treatment of anemia [8].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Changes of Serum Ferritin Concentration in Mice during Exercise and Recovery

2020

IJHPM

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Iron is an indispensable important element in the human body. Serum ferritin is a reservoir of iron. Serum protein concentration is an important indicator of the health of the shadow body. Both high and low concentrations are not conducive to physical health. The purpose of this article is to study the specific situation of the dynamic change of serum ferritin concentration during exercise and recovery. This article takes the white rat as the experimental object and uses radioimmunoassay to dynamically determine and analyze the serum ferritin concentration during exercise and recovery of the white rat result. The results of the study show that, compared with the quiet time, exercise can reduce the serum ferritin concentration in the mice from the original 36.7ng/ml to 27.1ng/ml, the concentration is reduced by 32.8%, and the serum ferritin concentration will gradually increase during recovery. After 4.2h, it returned to the quiet level, indicating that exercise can sharply reduce the serum iron albumin concentration in a short period of time, causing exercise anemia. Therefore, exercise and recovery after exercise can cause changes in the serum protein concentration in the body, change the metabolism rate of serum ferritin in the human body, and have a certain regulating effect on the serum ferritin concentration.

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Efficacy of hepatic T2* MRI values and serum ferritin concentration in predicting thalassemia major classification for hematopoietic stem cell transplantation

Cited by 6 publications

References 40 publications

A Multicenter Retrospective Analysis Stressing the Importance of Long-Term Follow-Up after Hematopoietic Cell Transplantation for β-Thalassemia

A Multicenter Retrospective Analysis Stressing the Importance of Long-Term Follow-Up after Hematopoietic Cell Transplantation for β-Thalassemia

Hemoglobinopathies (Sickle Cell Disease and Thalassemia)

Dynamic Changes of Serum Ferritin Concentration in Mice during Exercise and Recovery

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