Efficacy of hepatic resectionvstransarterial chemoembolization for solitary huge hepatocellular carcinoma

Abstract

Our findings suggest that HR can be safe and more effective than TACE for patients with solitary huge HCC.

Patterns and challenges of treatment sequencing in patients with hepatocellular carcinoma: Experience from a German referral center

“…Resection was most often performed in the first line setting. The outcome of our BCLC B patients after surgery was very good with a median OS of 51 months and comparable with the results of former studies with a median OS range from 41 to 52 months . In contrast, BCLC B patients treated with TACE in our cohort had a mOS of only 20 months.…”

“…In contrast, BCLC B patients treated with TACE in our cohort had a mOS of only 20 months. These survival data are in line with several retrospective studies including propensity score matched analyses and also a randomized controlled trial comparing resection versus TACE, which have shown that outcome is better in patients treated with resection compared with those treated with TACE . Based on these findings, resection should therefore be preferred whenever possible.…”

“…The outcome of our BCLC B patients after surgery was very good with a median OS of 51 months and comparable with the results of former studies with a median OS range from 41 to 52 months. [23][24][25][26] In contrast, BCLC B patients treated with TACE in our cohort had a mOS of only 20 months. These survival data are in line with several retrospective studies including propensity score matched analyses and also a randomized controlled trial comparing resection versus TACE, which have shown that outcome is better in patients treated with resection compared with those treated with TACE.…”

“…These survival data are in line with several retrospective studies including propensity score matched analyses and also a randomized controlled trial comparing resection versus TACE, which have shown that outcome is better in patients treated with resection compared with those treated with TACE. [23][24][25][26][27] Based on these findings, resection should therefore be preferred whenever possible. Patients treated with RFA in first line were also more often BCLC B than BCLC A.…”

Outcomes of conventional transarterial chemoembolization for hepatocellular carcinoma ≥10 cm

“…In previous studies, the 5‐year OS rate of patients with HCC ≥10 cm treated by surgical resection was 16.3–40.2% . However, resection of huge HCCs can only be indicated for highly selected patients and is still challenging because of the increased bleeding, higher risk of liver failure, and other complications . In addition, both extrahepatic recurrence and early recurrence ≤12 months after resection develop more frequently .…”