Efficacy of He-Ne Laser in the prevention and treatment of radiotherapy-induced oral mucositis in oral cancer patients

Arora, Honey; Pai, Keerthilatha M.; Maiya, Arun G.; Vidyasagar, M S; Rajeev, AG

doi:10.1016/j.tripleo.2007.07.043

Cited by 126 publications

(94 citation statements)

References 11 publications

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“…However, some studies have shown useful findings in treatment of dentin hypersensitivity, temporomandibular joint disorders, inferior alveolar nerve paraesthesia resulting from third molar surgery, sagittal osteotomy, trigeminal neuralgia, labial herpes, aphthous ulcers and post-chemotherapy and ray inflammation. [7][8][9][10][11][12] As there are conflicting findings regarding the effectiveness of low-level laser therapy (LLLT) and the importance of controlling third molar surgery's complications, this study aimed to assess the effect of LLLT on pain, swelling and maximum mouth opening in patients undergoing third molar surgery. In this study, we increased the number and variety of studied groups in order to reduce the error rate, in comparison to former researches.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Low-Level Laser Therapy Effects After Extraction of Impacted Lower Third Molar Surgery

et al. 2017

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IntroductionThird molar surgery is almost one of the most frequent procedures performed by maxillofacial surgeons. The surgical trauma leads to post-operation complications such as pain, inflammation and trismus.1 About 3-5 hours following surgery, the pain reaches its maximum intensity and may last 2-3 days; and then diminishes within 7 days after surgery.2,3 Moreover, post-operative inflammation disappears 5-7 days after surgery. 4 It has been recommended to use local or systemic steroid and non-steroid anti-inflammatory therapy to reduce inflammation and relieve pain after molar surgery, but these drugs present some side effects, including gastrointestinal issues, systemic bleeding and allergic reactions.5 Several studies have demonstrated that laser therapy can accelerate cell and tissue reconstruction as well as relieve post-operative pain. 5,6 Laser therapy is an open research field. However, some studies have shown useful findings in treatment of dentin hypersensitivity, temporomandibular joint disorders, inferior alveolar nerve paraesthesia resulting from third molar surgery, sagittal osteotomy, trigeminal neuralgia, labial herpes, aphthous ulcers and post-chemotherapy and ray inflammation. [7][8][9][10][11][12] As there are conflicting findings regarding the effectiveness of low-level laser therapy (LLLT) and the importance of controlling third molar surgery's complications, this study aimed to assess the effect of LLLT on pain, swelling and maximum mouth opening in patients undergoing third molar surgery. In this study, we increased the number and variety of studied groups in order to reduce the error rate, in comparison to former researches. To eliminate the possible differences between several people in relevance to pain amount and also their reports on it, a bilateral surgery group was used to study the effects of LLLT on the post-operation pain and swelling. On the other hand, as maximum mouth The aim of this study was to assess the effect of low-level laser therapy (LLLT) on pain, swelling and maximum mouth opening in patients undergoing third molar surgery. Methods: A prospective, randomized double-blind study was undertaken on 44 patients at the Dental School, Ahvaz Jundishapur University of Medical Sciences, in 2015. A lowlevel laser was randomly applied on one of the two sides after surgery of 15 patients. The experimental side received 18 J/cm 2 of energy density, wavelength of 980 nm, and output power of 1.8 W. On the control side, a hand-piece was applied intra-orally, but laser was not activated. In addition, in order to evaluate trismus, 13 patients were treated by unilateral laser therapy and 16 patients did not receive laser therapy at all. The laser was administered intraorally on two points of vestibular and lingual sides at 1 cm from the surgery site, and extraorally at the emergence of the masseter muscle, immediately after surgery, and repeated 24 hours later. The pain, swelling and maximum mouth opening (MMO) were compared between the two groups at 24 hours and a week after surger...

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Section: Introductionmentioning

confidence: 99%

Assessment of Low-Level Laser Therapy Effects After Extraction of Impacted Lower Third Molar Surgery

et al. 2017

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“…Prophylactic use of LPT seems to be more effective than when it is used following the establishment of the disease, although the reason is not entirely clear (16). The patient of this case was referred to the Laser Center by the oncologist only after the oral mucositis lesions had been established.…”

Section: Discussionmentioning

confidence: 92%

“…Accordingly, Zanin et al (1) and Lopes et al (17) reported that in their studies all patients under RT who received LPT completed the planned RT treatment, whereas patients not treated with LPT had to interrupt the RT because of decreased immunity caused by secondary asthenia and deglutition difficulties, which impacted their survival. Several protocols have been used for treating oral mucositis and the observed results sometimes differ (1,3,4,13,16,17). It is necessary to standardize the protocols for prevention and treatment of this condition in order to make different studies comparable.…”

Section: Discussionmentioning

confidence: 99%

Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Lino

Carvalho

Oliveira³

et al. 2011

Braz. Dent. J.

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Oral mucositis is a harmful side effect of radiotherapy (RT) on the head and neck region. There are encouraging reports on the beneficial aspects of the use of laser light on the treatment of oral mucositis. This paper reports the efficacy of laser phototherapy (LPT) on the treatment of oral mucositis in a patient undergoing RT after surgical removal of a squamous cell carcinoma with osseous invasion of the maxilla. Palatal and commissural lesions were treated with l660 nm, 40 mW, ∅=4 mm 2 , in contact mode, 5 x 2.4 J/cm 2 per point, 14.4 J/cm 2 per session. For treating the lesion on the patient's nasal mucosa, LPT (∅=4 mm 2 , l780 nm, 70 mW, 3 x 2.1 J/cm 2 per point, 6.3 J/cm 2 per session, contact mode) was used on the external area of the nose. A single dose (2.4 J/cm 2 ) with the l660 nm laser, as described before, was applied on the entrance of each nostril. LPT was used 3 times/week during 4 weeks. Treatment results indicate that the use of LPT on oral mucositis was effective and allowed the patient to carry on the RT without interruption. However, long-term and controlled clinical trials are necessary to establish both preventive and curative protocols using LPT.

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“…The prevalence of oral mucositis resulting from radiation is 36% to 100% of patients 13 . During radiation therapy, the first symptoms of mucositis appear with a dosage of radiation equivalent to 1000 cGY, which generally occurs in the first week of treatment 6,14 .…”

Section: Mucositismentioning

confidence: 99%

“…The use of low-power laser therapy has been efficacious in controlling mucositis symptoms. Studies conducted by Arora et al 13 report that laser treatment applied prophylactically during radiation therapy may reduce the severity of oral mucositis. It promotes the release of prostaglandins, which enables anti-inflammatory action, and promotes the release of endorphins that help to control the pain 23 .…”

Section: Literature Reviewmentioning

confidence: 99%

Oral complications in patients receiving head and neck radiation therapy: a literature review

Sari¹,

Nasiloski

Gomes

2014

RGO, Rev. Gaúch. Odontol.

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Oral cancer is a relatively common disease worldwide and its incidence rate has increased over the years. In Brazil, thousands RESUMOO câncer bucal é uma doença relativamente comum a nível mundial e que vem aumentando a sua incidência ao longo dos anos. No Brasil, milhares de novos casos surgem e o cirurgião-dentista é o profissional que precisa estar preparado para diagnosticar, prevenir, intervir e orientar os pacientes quanto a doença, seu tratamento e as complicações inerentes ao mesmo. Não existe, atualmente, uma forma de tratamento sistêmico para o câncer que tenha a capacidade de destruir as células alteradas, sem causar dado ou a morte das células normais. A cirurgia combinada com a radioterapia é uma das formas mais comuns para tratamento dos tumores malignos de cabeça e pescoço. Essa modalidade de tratamento tem obtido altos índices de cura e sobrevida aos pacientes, porém, os efeitos colaterais existentes são graves e capazes de provocar morbidade aos pacientes, diminuindo a sua qualidade de vida. Desse modo, o objetivo do trabalho é realizar uma revisão de literatura sobre as principais complicações decorrentes do tratamento radioterápico, enfatizando a conduta do cirurgião-dentista frente a estas alterações.

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Efficacy of He-Ne Laser in the prevention and treatment of radiotherapy-induced oral mucositis in oral cancer patients

Cited by 126 publications

References 11 publications

Assessment of Low-Level Laser Therapy Effects After Extraction of Impacted Lower Third Molar Surgery

Assessment of Low-Level Laser Therapy Effects After Extraction of Impacted Lower Third Molar Surgery

Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Oral complications in patients receiving head and neck radiation therapy: a literature review

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