Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

İdiz, Oğuz; Ayşan, Erhan; Fırat, Deniz; Ersoy, Yeliz Emine; Cengiz, Merve; Akbulut, Hüseyin; Işık, Arda; Müslümanoğlu, Mahmut

doi:10.12659/msm.890460

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Our extensive literature review suggests it is unlikely that any single approach will sufficiently inhibit PF. Many new approaches have recently been reported, such as the application of cross-linked high-molecular-weight hyaluronic acid, hyperbaric oxygen treatment, and hybrid chitosan membranes [ 17 , 28 – 30 ]. Thus, we hypothesized that PF could be significantly prevented with the combined application of RPM with these new approaches.…”

Section: Discussionmentioning

confidence: 99%

Effects of Rapamycin on Reduction of Peridural Fibrosis: An Experimental Study

et al. 2015

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BackgroundPeridural fibrosis (PF) is a normal complication after lumbar surgery. It is a challenge for both surgeons and patients. Rapamycin (RPM), a novel antibiotic with anti-proliferative and immunosuppressive properties, has been shown to be effective in preventing uncontrolled scar proliferation diseases. The object of the present research was to investigate the effects of RPM on inhibiting PF in vitro and in vivo.Material/MethodsIn vitro, the fibroblasts collected and isolated from the rat tail skin were cultured with/without RPM and cell counting was performed. In vivo, the double-blinded study was conducted in 60 healthy Wistar rats divided randomly into 3 groups: 1) RPM treatment group; 2) Vehicle treatment group; 3) Control group. Rats underwent a L1-L2 level laminectomy with a satisfactory anesthetization. Four weeks post-operatively, the Rydell score, histological analysis, hydroxyproline content, vimentin expressional level, and inflammatory cytokines expressional levels were assessed.ResultsIn vitro, RPM showed ability to prevent fibroblast proliferation. In vivo, the laminectomy was well tolerated by all rats, which were killed 4 weeks post-operatively. The Rydell score, histological evaluation, hydroxyproline content, vimentin expression level, and inflammatory activity showed the positive effect of RPM in preventing peridural adhesion, inhibiting fibrotic formation and collagen synthesis, and down-regulating inflammation.ConclusionsIn the present primary study, RPM showed good efficacy in preventing the proliferation of fibroblasts. RPM can prevent rat peridural adhesion through inhibiting collagen synthesis, fibroblasts proliferation, and inflammatory activity.

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Section: Discussionmentioning

confidence: 99%

Effects of Rapamycin on Reduction of Peridural Fibrosis: An Experimental Study

et al. 2015

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Effect of Extractum Cepae, Heparin Sodium and Allantoin Combination (Contractubex) on Adhesion and Fibrosis After Neck Surgery (Thyroidectomy) in Rats

Balas¹

2021

North Clin Istanbul

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OBJECTIVE Reoperative thyroid surgery is technically difficult process with increased complications due to the adhesions and fibrosis caused by the previous surgery. In this experimental animal model, we planned to investigate the effect of Contracttubex TM , a mixture of Extractum cepae, Heparin sodium and Allantoin, on adhesion and fibrosis after neck surgery (thyroidectomy). METHODS The current study is an experimental animal model of post-thyroidectomy adhesion. Twelve Wistar-Albino male rats in two groups were used. Under sterile conditions, a midline incision on the neck was made. The anterior thyroid muscles were separated and the thyroid lodge was reached. As a minor interventional procedure, a sponge was applied to the thyroid tissue, and then a combination of 1 g Extractum capae, heparin, sodium, and allantoin was applied to the dissection site in the drug group. Rats in both groups were sacrificed on 30 th day. Cervical regions were dissected and evaluated for macroscopic adhesion. Tissue samples were taken for microscopic evaluation for fibrosis and inflammation. RESULTS In the experimental group in which Contractubex TM was applied, inflammation was not detected in five (83.3%) of six rats while no inflammation was detected in four (66.7%) of six rats in the control group (p=0.505). Considering the fibrosis score, mild or moderate fibrosis was detected in four (66.7%) of six rats in the control group, while fibrosis was found in only two (33.3%) rats in the experimental group (p=0.264). When macroscopic adhesion was evaluated, two (33.3%) rats of the control group subjects were Grade 4, and one (16.7%) was Grade 3. No rats in the experimental group were Grade 4 (p=0.392). CONCLUSION Contractubex TM seems to be effective in preventing adhesions and fibrosis after thyroidectomy and neck surgery, but further research is needed for use in human studies.

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