Efficacy of ginger on intraoperative and postoperative nausea and vomiting in elective cesarean section patients

Effect of Low-Dose Intravenous Ketamine on Prevention of Headache After Spinal Anesthesia in Patients Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial Study

“…A study by Song et al showed that the use of ketamine in patients not only did not reduce the incidence of nausea and vomiting but also increased its prevalence and severity in patients (25). Nausea and vomiting cause stress for the patient, surgeon, and anesthesiologist and it causes distress, disgust, increased anxiety, and inefficiency in patients, and if continued, it leads to lowering blood pressure and lowers heart rate (26). Therefore, prevention and attention to this issue are of great importance.…”

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7

“…To date, the effectiveness of ginger in controlling nausea remains controversial. Ginger is superior to placebo in treating nausea in several studies,[10,11] whereas its effects are not significant in other studies [12,13]…”

“…Ginger is superior to placebo in treating nausea in several studies, [10,11] whereas its effects are not significant in other studies. [12,13] Gingerols (e.g. 6-, 8-and 10-gingerol; Figure 1) are the principal pungent constituents of ginger with many types of pharmacological effects, such as antitumour-promoting activity.…”

Is ginger beneficial for nausea and vomiting? An update of the literature

“…The identified clinical studies that have investigated postoperative nausea and vomiting and CINV, for example have generally reported statistically significant reductions in measures of nausea and vomiting; however, the magnitude of this reduction was generally small and so less likely to result in a substantial benefit to the patient [11,14,17]. The study conducted by Dabaghzadeh et al [16 & ] in contrast, demonstrated a considerable difference between the intervention and placebo group and if further studies report similar findings, this is likely to provide a clinically significant benefit to the patient.…”

“…In addition to postoperative nausea and vomiting, Kalava et al [14] investigated the use of 1 g ginger supplementation for intraoperative nausea and vomiting in 239 participants receiving elective caesarean section. The results showed a statistically significant reduction in the frequency of intraoperative nausea but not intraoperative vomiting or postoperative nausea or vomiting.…”