Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study

Thamlikitkul, Lucksamon; Srimuninnimit, Vichien; Akewanlop, Charuwan; Ithimakin, Suthinee; Techawathanawanna, Sirisopa; Korphaisarn, Krittiya; Chantharasamee, Jomjit; Danchaivijitr, Pongwut; Soparattanapaisarn, Nopadol

doi:10.1007/s00520-016-3423-8

Cited by 48 publications

(49 citation statements)

References 17 publications

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“…After excluding duplicates, the 42 remaining studies were screened by their title and abstract of which 33 were excluded due to the following reasons: (a) 16 studies were review articles, (b) 13 of them were not relevant in exposure or outcome, (c) one study was animal based, (d) one study was a conference paper, and (e) two papers were commentary or editorial. Finally, nine trials (Ansari et al, ; Arslan & Ozdemir, ; Lua, Salihah, & Mazlan, ; Panahi et al, ; Ryan et al, ; Salihah, Mazlan, & Lua, ; Sanaati et al, ; Thamlikitkul et al, ; Yekta et al, ) were included in this review, which were published between 2012 and 2017 (Table ). Included studies were conducted in Turkey (one study), Malaysia (two studies), Iran (four studies), United States (one study), and Thailand (one study).…”

Section: Resultsmentioning

confidence: 99%

“…The five studies included in this systematic review were double blinded randomized controlled trials (Ansari et al, ; Ryan et al, ; Sanaati et al, ; Thamlikitkul et al, ; Yekta et al, ). A cross‐over design was applied in three studies (Lua et al, ; Salihah et al, ; Thamlikitkul et al, ). One study was open label (Panahi et al, ), and two studies were single‐blind randomized controlled trials (Lua et al, ; Salihah et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The efficacy of ginger in preventing nausea and vomiting has been assessed in a number of clinical trials in patients with various conditions, such as pregnancy and postoperative nausea and vomiting (Chaiyakunapruk, Kitikannakorn, Nathisuwan, Leeprakobboon, & Leelasettagool, ; Thomson, Corbin, & Leung, ; Viljoen, Visser, Koen, & Musekiwa, ). Studies on the efficacy of ginger on the number and severity of nausea and vomiting episodes in different phases of chemotherapy in breast cancer patients have shown conflicting results (Arslan & Ozdemir, ; Panahi et al, ; Sanaati, Najafi, Kashaninia, & Sadeghi, ; Thamlikitkul et al, ). A systematic review and meta‐analysis study have reviewed this relationship in all types of cancers and concluded that there is no evidence that supports the use of ginger to prevent CINV (Jiyeon Lee, ).…”

Section: Introductionmentioning

confidence: 99%

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The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

Totmaj

Emamat

Jarrahi

et al. 2019

Phytotherapy Research

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Breast cancer is the most commonly diagnosed cancer and is the leading cause of mortality due to all types of cancers among the female population worldwide. Results of clinical trials investigating the effect of ginger on chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients are inconsistent. This study was aimed at obtaining a comprehensive overview of the current evidence regarding the effectiveness of ginger as an antiemetic modality for controlling CINV in breast cancer patients. All published randomized controlled trials in English were systematically searched on Google Scholar, PubMed, Scopus, and Cochrane search databases up to June 2018. The outcome variable of interest was severity and the frequency of nausea and vomiting in patients. A total of 50 studies were found through search databases. After excluding duplicates, the 42 remaining studies were screened, and finally, nine trials were included, which were published between 2012 and 2017.Two studies have examined the effect of ginger on the frequency of nausea, five studies on the frequency of vomiting, seven studies on the severity of nausea, and three studies on severity of vomiting. A study evaluated the effectiveness of ginger in improving dietary intake in CINV. Our investigation suggests that ginger may reduce nausea in the acute phase of chemotherapy in patients with breast cancer.The effect of ginger on nausea and vomiting in other conditions requires more high-quality clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

Totmaj

Emamat

Jarrahi

et al. 2019

Phytotherapy Research

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“…In traditional medicine, ginger powder is prescribed for some ailments such as vomiting, indigestion, joint and muscular pain, and cold (Ali et al, 2008). Moreover, its various pharmacological effects have been reported including antiemetic (Palatty, Haniadka, Valder, Arora, & Baliga, 2013), anti-inflammatory and antioxidant (Grzanna, Lindmark, & Frondoza, 2005;Mashhadi et al, 2013), glucose and lipid lowering (Li, Tran, Duke, & Roufogalis, 2012;Mahluji et al, 2013), and anticancer effects (Pereira, Haniadka, Chacko, Palatty, & Baliga, 2011;Thamlikitkul, Srimuninnimit, Akewanlop, et al, 2017).…”

mentioning

confidence: 99%

A systematic review of the anti‐obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action

Attari

Mahdavi

Javadivala

et al. 2017

Phytotherapy Research

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Recently, the beneficial effects of ginger on obesity is taken into consideration. Albeit, it seems that the anti-obesity effect of ginger and its mechanism of action has not yet been reviewed. Therefore, the aim of this study was to systematically review the effect of Zingiber officinale Roscoe on obesity management. Databases including PubMed, Scopus, Google scholar, and Science Direct were searched from 1995 until May 2017 using the definitive keywords. Searching was limited to articles with English language. All of the relevant human and animal studies and also in vitro studies were included. Review articles, abstract in congress, and also other varieties of ginger were excluded. Eligibility of included articles were evaluated by 3 reviewers, which also extracted data. Articles were critically assessed individually for possible risk of bias. Twenty-seven articles (6 in vitro, 17 animal, and 4 human studies) were reviewed. Most of the experimental studies supported the weight lowering effect of ginger extract or powder in obese animal models, whereas the results of the available limited clinical studies showed no changes or slight changes of anthropometric measurements and body composition in subjects with obesity. Ginger could modulate obesity through various potential mechanisms including increasing thermogenesis, increasing lipolysis, suppression of lipogenesis, inhibition of intestinal fat absorption, and controlling appetite. This review article provides some convincing evidence to support the efficacy of ginger in obesity management and demonstrates the importance of future clinical trials.

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“…The standard of care for chemotherapy-induced vomiting is antiemetics, most notably serotonin (5-HT3) receptor antagonists and glucocorticoids, such as dexamethasone; however, efforts to control nausea have not been successful (Bloechl-Daum, Deuson, Mavros, Hansen, & Herrstedt, 2006;Herrstedt & Roila, 2008). The summary of studies evaluating the effects of ginger consumption on chemotherapy-related nausea and vomiting is shown in Table 2 ( Ansari et al, 2016;Arslan & Ozdemir, 2015;Fahimi et al, 2011;Manusirivithaya et al, 2004;Marx et al, 2013;Panahi et al, 2012;Pillai, Sharma, Gupta, & Bakhshi, 2011;Ryan et al, 2012;Sanaati, Najafi, Kashaninia, & Sadeghi, 2016;Sontakke, Thawani, & Naik, 2003;Thamlikitkul et al, 2017;Zick et al, 2009). Nausea and vomiting can occur after surgery, medications, or even exercise.…”

Section: Naus E a And Vomitingmentioning

confidence: 99%

Ginger in gastrointestinal disorders: A systematic review of clinical trials

Bodagh

Maleki

Hekmatdoost

2018

Food Science & Nutrition

101

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Ginger, the rhizome of Zingiber officinale, which is used as a spice globally has a long history of medicinal use that stimulates investigators to assess its potential roles as an adjuvant therapy or alternative medicine in a range of diseases. Anti‐inflammatory, antioxidant, antitumor, and antiulcer effects of ginger have been proven in many scientific studies, and some of the ancient applications of ginger as a home remedy has been confirmed in human. In this review, we summarized the current evidence on the effects of ginger consumption on gastrointestinal disorders based on clinical trials. Our data indicate that divided lower daily dosage of 1500 mg ginger is beneficial for nausea relief. Because of limited number of studies on some other gastrointestinal disorders, the results may not be as much powered as to find significant results. Therefore, more extensive and well‐controlled human studies of ginger or its standard extracts are required to demonstrate its efficacy as a gastroprotective agent. Dose‐finding studies should be undertaken to accurately determine the effective dose and preparation of ginger in further clinical trials protocol.

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Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study

Abstract: Ginger (500 mg) twice daily was safe, but conferred no additional benefit in terms of reducing nausea severity in breast cancer patients receiving AC and ondansetron and dexamethasone for CINV prophylaxis.

Cited by 48 publications

References 17 publications

The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

The effect of ginger (Zingiber officinale) on chemotherapy‐induced nausea and vomiting in breast cancer patients: A systematic literature review of randomized controlled trials

A systematic review of the anti‐obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action

Ginger in gastrointestinal disorders: A systematic review of clinical trials

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