Efficacy of genotype notification to Japanese smokers on smoking cessation—An intervention study at workplace

Hishida, Asahi; Terazawa, T.; Mamiya, Toshiko; Ito, Hidemi; Matsuo, Keitaro; Tajima, Kazuo; Hamajima, Nobuyuki

doi:10.1016/j.canep.2009.11.008

Cited by 26 publications

(73 citation statements)

References 33 publications

(43 reference statements)

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“…Most included studies have been conducted in the USA and Japan, sample sizes ranged from 61 to 697 and mean age varied from 39.2 to 69.0 years. Concerning the effectiveness of genetic testing on smoking cessation, two studies tested smokers for the L-myc gene,25 26 one study tested the CYP2D6 gene29 30 and two studies used the GSTM1 gene 27 28…”

Section: Resultsmentioning

confidence: 99%

“…Three studies examined the effect of genetic testing on risk perception26 28 29 and four studies examined the effects on motivation to quit 25 26 28 29. In general (see table 4), there seems to be a small immediate effect of genetic testing on risk perception28 29 that disappears at longer follow-ups 26.…”

Section: Resultsmentioning

confidence: 99%

“…Effects were described using r . However, as some studies reported risk perception and motivation as dichotomous variables25 26 and others as continuous variables,27 28 we decided not to calculate a pooled estimate for these variables.…”

Section: Methodsmentioning

confidence: 99%

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Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis

2011

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis

2011

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“…25 A study of knowledge about L-myc polymorphisms to motivate smoking cessation showed no effect. 26 In contrast, a recent study showed that simply informing a patient of his or her lung age, a low-cost technique requiring only a spirometer, more than doubled the 12-month quitting rate compared with conventional treatment. 27 Pharmacogenetics-the use of genetic testing to help identify the regimen most likely to benefi t a smoker with a particular genotype-appears more promising.…”

Section: Evidence That Genetic Knowledge Increases Smoking Cessationmentioning

confidence: 96%

Personalized Medicine and Tobacco-Related Health Disparities: Is There a Role for Genetics?

Carlsten

Halperin²,

Crouch³

et al. 2011

The Annals of Family Medicine

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Genetic testing has been proposed as a means to increase smoking cessation rates and thus reduce smoking prevalence. To understand how that might be practically possible, with appreciation of the current social context of tobacco use and dependence, we performed a contextual analysis of smoking-related genetics and smoking cessation. To provide added value, genetics would need to inform and improve existing interventions for smokers (including behavioral and pharmacological treatments). Pharmacogenetics offers the most promising potential, because it may improve the effi cacy of medication-based smoking cessations strategies. All proven interventions for treating tobacco dependence, however, including simple cost-effective measures, such as quit lines and physician counseling, are underutilized. As tobacco use occurs disproportionately among disadvantaged populations, efforts to improve smokers' access to health care, and to the tools that are known to help them quit, represent the most promising approaches for reducing smoking prevalence within these groups. Similar considerations apply to other chronic diseases contributing to population-level health disparities. We conclude that although genetics offers increasing opportunities to tailor drug treatment, and may in some cases provide useful risk prediction, other methods of personalizing care are likely to yield greater benefi t to populations experiencing health disparities related to tobacco use.

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“…Though these studies indicate that test results may increase an individual’s motivation to quit smoking, there appears to be no increase in long-term quit rates [39,40,41,42,43,44]. It is less clear how predictive tests might affect smoking prevention efforts.…”

Section: Introductionmentioning

confidence: 99%

Integrating Genetic Studies of Nicotine Addiction into Public Health Practice: Stakeholder Views on Challenges, Barriers and Opportunities

Dingel

Hicks²,

Robinson³

et al. 2011

Public Health Genomics

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Objective: Will emerging genetic research strengthen tobacco control programs? In this empirical study, we interview stakeholders in tobacco control to illuminate debates about the role of genomics in public health. Methods: The authors performed open-ended interviews with 86 stakeholders from 5 areas of tobacco control: basic scientists, clinicians, tobacco prevention specialists, health payers, and pharmaceutical industry employees. Interviews were qualitatively analyzed using standard techniques. Results: The central tension is between the hope that an expanding genomic knowledge base will improve prevention and smoking cessation therapies and the fear that genetic research might siphon resources away from traditional and proven public health programs. While showing strong support for traditional public health approaches to tobacco control, stakeholders recognize weaknesses, specifically the difficulty of countering the powerful voice of the tobacco industry when mounting public campaigns and the problem of individuals who are resistant to treatment and continue smoking. Conclusions: In order for genetic research to be effectively translated into efforts to minimize the harm of smoking-related disease, the views of key stakeholders must be voiced and disagreements reconciled. Effective translation requires honest evaluation of both the strengths and limitations of genetic approaches.

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Efficacy of genotype notification to Japanese smokers on smoking cessation—An intervention study at workplace

Cited by 26 publications

References 33 publications

Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis

Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis

Personalized Medicine and Tobacco-Related Health Disparities: Is There a Role for Genetics?

Integrating Genetic Studies of Nicotine Addiction into Public Health Practice: Stakeholder Views on Challenges, Barriers and Opportunities

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