Efficacy of Gabapentin in the Management of Pruritus of Unknown Origin

Yesudian, Patrick; Wilson, N. J. E.

doi:10.1001/archderm.141.12.1507

Cited by 90 publications

(62 citation statements)

References 24 publications

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“…8,9 Several case reports 8,[10][11][12] document the successful use of gabapentin at varying dosages (range, 100 mg 3 times daily to 300 mg every 4 hours) for brachioradial pruritus. Although the mechanism of action of gabapentin is unknown, it affects neurotransmitters; specifically, it inhibits glutamate synthesis and increases the transmission of ␥-aminobutyric acid.…”

Section: Commentmentioning

confidence: 99%

Scalp Dysesthesia Related to Cervical Spine Disease

Thornsberry¹,

English²

2013

JAMA Dermatol

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Section: Commentmentioning

confidence: 99%

Scalp Dysesthesia Related to Cervical Spine Disease

Thornsberry¹,

English²

2013

JAMA Dermatol

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“…Actually, some clinical studies have already demonstrated antipruritic effects of gabapentin and pregabalin. [67][68][69][70] …”

Section: Neuropathic Itchmentioning

confidence: 99%

Updated Neurophysiology of Itch

Ikoma¹

2013

Biological & Pharmaceutical Bulletin

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The unique physiological features of histamine-sensitive C-fibers and spinothalamic tract neurons support the hypothesis of itch specific pathway, whereas subsequent studies on cowhage-induced itch have provided evidence against it, suggesting the presence of multiple neural pathways for itch. Not only peripheral pruritogens but also spinal neural receptors are involved in the control of itch, and will be the target of treatment. Itch sensitization in chronic pruritus is another crucial factor that needs to be considered in the treatment. Neuropathic itch is the type of itch that occurs when nerve fibers are damaged or injured and spontaneous firing of nerves takes place, and plays a major role in itch accompanying some pathological conditions such as herpes zoster. The complexity of itch is due to the broad range of mediators involved and the large variety of neural mechanisms behind.

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“…These synapses in the superficial laminae of the dorsal horn at the spinal level transmit signals via interneurons through the anterolateral spinothalamic tract. Supraspinal processing is in the anterior cingulate cortex, supplementary motor area and inferior parietal lobe, with a left hemisphere dominance [7,11,24].…”

Section: Pathophysiology Of Itch Sensationmentioning

confidence: 99%

“…Its efficacy in relieving all kinds of pruritus has now been reported [2,[10][11][12][13]. Its efficacy and safety in paediatric patients have been studied in epilepsy (given in doses of 20-30 mg kg −1 day −1 [14,15], up to a maximum of 40 mg kg −1 day −1 for refractory epilepsy [16]).…”

Section: Introductionmentioning

confidence: 99%