Efficacy of Flavonoids on Animal Models of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Zhang, Jiacheng; Zhang, Haolin; Xin, Xiyan; Zhu, Yutian; Ye, Yang; Liu, Dong

doi:10.3390/nu14194128

Cited by 10 publications

(3 citation statements)

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“…Recent research highlights that the effects of natural products depend significantly on their (micro)environment, cell type, and nanoformulation, allowing for the development of various drug delivery systems [ 77 ]. Previous systematic reviews and meta-analyses have identified factors such as the induction agent, type of natural product, route of drug delivery, animal model, treatment dosage, and duration of administration as potential sources of substantial heterogeneity between studies [ 78 , 79 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Hu,

Zhang,

Xin

et al. 2024

J Ovarian Res

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Objective This study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF). Methods We conducted comprehensive literature searches and identified relevant studies that examined the protective effects of natural products on experimental POF. We extracted quantitative data on various aspects such as follicular development, ovarian function, physical indicators, oxidative stress markers, inflammatory factors, and protein changes. The data was analyzed using random-effects meta-analyses, calculating pooled standardized mean differences and 95% confidence intervals. Heterogeneity was assessed using the I2 statistic, and bias was estimated using the SYRCLE tool. Results Among the 879 reviewed records, 25 articles met our inclusion criteria. These findings demonstrate that treatment with different phytochemicals and marine natural products (flavonoids, phenols, peptides, and alkaloids, etc.) significantly improved various aspects of ovarian function compared to control groups. The treatment led to an increase in follicle count at different stages, elevated levels of key hormones, and a decrease in atretic follicles and hormone levels associated with POF. This therapy also reduced oxidative stress (specifically polyphenols, resveratrol) and apoptotic cell death (particularly flavonoids, chrysin) in ovarian granulosa cells, although it showed no significant impact on inflammatory responses. The certainty of evidence supporting these findings ranged from low to moderate. Conclusions Phytochemicals and marine natural product therapy (explicitly flavonoids, phenols, peptides, and alkaloids) has shown potential in enhancing folliculogenesis and improving ovarian function in animal models of POF. These findings provide promising strategies to protect ovarian reserve and reproductive health. Targeting oxidative stress and apoptosis pathways may be the underlying mechanism.

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Section: Discussionmentioning

confidence: 99%

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Hu,

Zhang,

Xin

et al. 2024

J Ovarian Res

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“…Marigold leaf extract is believed to contain active compounds that can influence the regulation of reproductive hormones [34]. The elevation of FSH levels after Marigold leaf extract administration can have a stimulating effect on the ovaries [35]. FSH is an important hormone in regulating the growth of ovarian follicles and the secretion of estrogen hormones [36].…”

Section: Effect Of Administration Of Ethanol Extract Of Marigold Leav...mentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Cigarette smoke produces particles such as nicotine, tar, and cadmium which can damage male germ cells and interfere with the hypothalamus, pituitary, and testicles which cause spermatogenesis disorders. The study aimed to analyze the differences in FSH levels in each group of mice (Mus musculus) exposed to cigarette smoke by administering ethanol extract from marigold leaves (Tegetes erecta). The laboratory experimental research method used a Randomized post-test-only control group design with exposure to one cigarette smoke 1 cigarette per day and administration of ethanol extract of marigold leaves (Tegetes erecta). The grouping of research samples used simple random sampling in 5 groups with experimental mice (Mus Musculus) males aged 8-12 weeks and weighing 20-25 grams which were divided into 5 groups, namely K(-) (placebo), K(+) (smoked cigarettes and placebo), P1 (cigarette smoke and marigold leaf extract dose 0.25 g/kg-BW), P2 (smoked cigarettes and marigold leaf extract dose 0.50 g/kg-BW), and P3 (smoked cigarettes and marigold leaf extract dose 1, 0 g/kg-BW). FSH levels were examined using ELISA. The results of the analysis of examining FSH levels showed an average of K(-): 0.80 mIU/ml, K(+): 0.60 mIU/ml, P1: 0.54 mIU/ml (dose 0.25 g/kg-BW), P2:0.60 mIU/ml (dose of 0.50 g/kg-BW), and P3:0.55 mIU/ml (dose of 1.0 g/kg-BW) with p-value ≤0.05. In conclusion, there was a significant effect of the administration of ethanol extract of marigold leaves (Tegetes erecta) on the FSH levels of mice exposed to cigarette smoke.

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“…Polycystic ovary syndrome (PCOS), characterized by chronic anovulation, hyperandrogenism, and insulin resistance, is one of the most common reproductive endocrinopathy affecting approximately 8% to 18% reproductive-aged women [ 1 ]. In addition to being an important cause of infertility, it is also a risk factor for many metabolic diseases, such as type 2 diabetes mellitus, cardiovascular continuum, and endometrial carcinoma [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Global burden and epidemiological prediction of polycystic ovary syndrome from 1990 to 2019: A systematic analysis from the Global Burden of Disease Study 2019

Zhang,

Zhu,

Wang

et al. 2024

PLoS ONE

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Objective To comprehensively assess the global, regional and national burden of polycystic ovary syndrome (PCOS) in incidence, prevalence, and years lived with disability (DLYs) based on the Global Burden of Disease Study (GBD) 2019. Methods This was a cross-sectional descriptive study. Data on PCOS incidence, prevalence, and DLYs from 1990 to 2019 were obtained from the GBD study 2019. According to the commonwealth income, WHO region, and the sociodemographic index, the estimates were demonstrated along with the estimated annual percentage change (EAPC). The EAPC data were analyzed by four levels of hierarchical clustering and displayed in the world map. The Autoregressive Integrated Moving Average (ARIMA) and Bayesian age-period-cohort (BAPC) model was used to predict the PCOS burden in the next 20 years. Results From 1990 to 2019, the number of PCOS incidence in one year increased from 1.4 million in 1990 to 2.1 million in 2019 (54.3%). Only the EAPC estimates of incidence in the Region of the Americas decreased, and their aged-standardized incidence rate (ASIR) values were the highest in 1990 and 2019. There was no significant correlation between human development index (HDI) and EAPC. However, when HDI < 0.7, EAPC of incidence and prevalence was positively correlated with HDI, and when HDI > 0.7, EAPC of incidence and prevalence was negatively correlated with HDI. Countries with the middle level HDI have the highest increasing trend of ASIR and age-standardized prevalence rate (ASPR). The 10 to 19 years old group had the highest incidence counts of PCOS globally. Besides, the ARIMA and BAPC model showed the consistent increasing trend of the burden of PCOS. Conclusion In order to better promote the early diagnosis and treatment, expert consensus and diagnosis criteria should be formulated according to the characteristics of different ethnic groups or regions. It is necessary to emphasize the early screening and actively develop targeted drugs for PCOS.

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Efficacy of Flavonoids on Animal Models of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 74 publications

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies

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Global burden and epidemiological prediction of polycystic ovary syndrome from 1990 to 2019: A systematic analysis from the Global Burden of Disease Study 2019

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