Efficacy of ficin and peroxyacetic acid against Salmonella enterica serovar Thompson biofilm on plastic, eggshell, and chicken skin

Nahar, Shamsun; Jeong, Ha Lim; Cho, Ah Jin; Park, Junha; Han, Sung-Hyun; Kim, Younsoo; Park, Si-Hong; Ha, Sang‐Do

doi:10.1016/j.fm.2022.103997

Cited by 10 publications

(2 citation statements)

References 47 publications

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“…Our results showed that ficin not only inhibits C. albicans biofilm formation, but also detaches pre-formed biofilms, which for the first time indicates its anti-fungal biofilm effect. Previous studies have confirmed that ficin controls bacterial biofilms, including those of S. aureus , S. epidermidis , S. mutans and Salmonella Enterica [ 15 – 18 ] . Combined with the findings of this study, we conclude that ficin controls not only bacterial biofilms but also fungal biofilms.…”

Section: Discussionmentioning

confidence: 91%

“…Our previous study displayed that ficin not only significantly inhibits biofilm formation of opportunistic cariogenic Streptococcus mutans ( S. mutans ), but also suppresses its cariogenic virulence including acid production and EPS synthesis [ 17 ]. Most recently, ficin was reported to have effectivity against Salmonella Enterica serovar Thompson biofilms [ 18 ]. However, the effect of ficin on fungal biofilms remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory effect of ficin on Candida albicans biofilm formation and pre-formed biofilms

Wang

Shen

et al. 2022

BMC Oral Health

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Background To investigate the effect of ficin, a type of proteases, on Candida albicans (C. albicans) biofilm, including forming and pre-formed biofilms. Methods Crystal violet tests together with colony forming unit (CFU) counts were used to detect fungal biofilm biomass. Live/dead staining of biofilms observed by confocal laser scanning microscopy was used to monitor fungal activity. Finally, gene expression of C. albicans within biofilms was assessed by qRT-PCR. Results According to our results, biofilm biomass was dramatically reduced by ficin in both biofilm formation and pre-formed biofilms, as revealed by the crystal violet assay and CFU count (p < 0.05). Fungal activity in biofilm formation and pre-formed biofilms was not significantly influenced by ficin according to live/dead staining. Fungal polymorphism and biofilm associated gene expression were influenced by ficin, especially in groups with prominent antibiofilm effects. Conclusions In summary, ficin effectively inhibited C. albicans biofilm formation and detached its preformed biofilm, and it might be used to treat C. albicans biofilm associated problems.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%