Efficacy of Fesoterodine on Nocturia and Quality of Sleep in Asian Patients With Overactive Bladder

Yokoyama, Osamu; Hiro, Shintaro; Hotta, Shinichi; Mogami, Satoru; Yamagami, Hidetomi

doi:10.1016/j.urology.2013.12.008

Cited by 22 publications

(22 citation statements)

References 25 publications

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“…This study looked specifically at fesoterodine, but the results may be generalizable to other anticholinergic and antimuscarinic medications (7). While BRIDGES examined the impact of the antimuscarinic therapy fesoterodine on women with UUI, antimuscarinic medication has been shown to reduce nighttime voiding as well as improves sleep quality in patients with nocturia (18). …”

Section: Discussionmentioning

confidence: 99%

Association of Pharmacologic Treatment of Urgency Urinary Incontinence With Sleep Quality and Daytime Sleepiness

Warsi

Huang

Hess

et al. 2018

Obstetrics &Amp; Gynecology

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Objective To evaluate the association between pharmacological therapy for urgency urinary incontinence (UUI) and sleep quality. Methods It is a planned secondary data analysis of sleep outcomes in a previously conducted multicenter, double-blinded, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence among community dwelling women self-diagnosed using the 3-Incontinence Questions (3-IQ) questionnaire. Participants (N = 645) were assigned randomly to antimuscarinic therapy 4–8 mg daily or placebo. At baseline and 12 weeks, participants completed a validated voiding diary to evaluate incontinence/voiding symptoms, the Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality, and the Epworth Sleepiness Scale to evaluate daytime sleepiness. Results Mean (SD) age was 56 (±14) years, 68% were white race, and 57% had poor sleep quality (PSQI score > 5). Mean frequency of any UI and UUI was 4.6 and 3.9 episodes per day, respectively. After 12-weeks, women randomized to the antimuscarinic group reported greater decrease compared to the placebo group in UUI frequency (0.9 episodes per day; P<0.001) and diurnal and nocturnal voiding frequency (P<0.05). As compared to the placebo group, women in the antimuscarinic group also reported greater improvement in sleep quality (total PSQI score 0.48; p=0.02), with greater improvement in sleep duration and sleep efficiency subscales (P<0.05). The intervention did not affect daytime sleepiness. Conclusions Pharmacological treatment of UUI is associated with decreased incontinence frequency and nocturia and improvement in overall sleep quality, sleep duration, and sleep efficiency. Clinical Trial Registration Clinical Trials.gov, NCT00862745.

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Section: Discussionmentioning

confidence: 99%

Association of Pharmacologic Treatment of Urgency Urinary Incontinence With Sleep Quality and Daytime Sleepiness

Warsi

Huang

Hess

et al. 2018

Obstetrics &Amp; Gynecology

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“…Although nocturnal micturitions/ 24 h improved in the two fesoterodine groups versus placebo, these treatment differences were not statistically significant. The most common adverse events were dry mouth (fesoterodine 4 mg, 28%; fesoterodine 8 mg, 50%; placebo, 9%) and constipation (fesoterodine 4 mg, 5%; fesoterodine 8 mg, 11%; placebo, 4%), with most mild or moderate and incidence rates higher with fesoterodine 8 mg than with fesoterodine 4 mg. Interestingly, a posthoc analysis of data from 555 patients with !1 nocturnal micturition/24 h at baseline demonstrated that nocturnal micturitions/24 h were significantly improved with fesoterodine 8 mg versus placebo at week 12 in patients without nocturnal polyuria (i.e., nocturnal polyuria index 33%) 66 .…”

Section: Asian Patientsmentioning

confidence: 95%

“…Patients with nocturia/nocturnal urgency Nocturia, based on the ICS definition of !1 micturition/ night 1,2 , is a common age-related condition, with population-based prevalence estimates of 24% to 49% in men and 30% to 55% in women aged !18 years 87,88 , and prevalence increasing with age [88][89][90] and body mass index 66 . Significant nocturia-related bother and impaired HRQL are reported by individuals with !2 micturitions/ night 35,36 .…”

Section: Patients With Uuimentioning

confidence: 98%

“…Four other fesoterodine trials with UUI as an enrollment requirement were conducted in patients with nocturia 66 , patients with a suboptimal response to tolterodine 72 , vulnerable elderly patients 80 , and Asian patients 85 . The results of these trials are summarized in subsequent sections focusing on these patient profiles.…”

Section: Patients With Uuimentioning

confidence: 99%

“…Urinary urgency was identified as a significant risk factor for nocturia (!2 micturitions/night) in both men (odds ratio ¼ 7.4) and women (odds ratio ¼ 4.9) 90 . Two trials have described the efficacy and safety of fesoterodine in patients with OAB symptoms, including nocturnal urgency episodes 65 and nocturia 66 .…”

Section: Patients With Uuimentioning

confidence: 99%

See 2 more Smart Citations

Fesoterodine clinical efficacy and safety for the treatment of overactive bladder in relation to patient profiles: a systematic review

Chapple

Oelke

Kaplan

et al. 2015

Current Medical Research and Opinion

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Extensive evidence demonstrates the efficacy and safety of fesoterodine in relieving OAB symptoms, including urgency, urinary frequency, UUI, and nocturnal urgency, in patients with various clinical and demographic profiles. Trial results provide valuable information on fesoterodine treatment in specific patient populations, including both elderly and vulnerable elderly patients. Potential limitations of this review are that only English language articles in PubMed were searched and included.

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Effectiveness of Japanese traditional medicine yokukansan for nocturia due to sleep disorders

Matsuo,

Mori,

Honda

et al. 2024

Traditional & Kampo Medicine

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AimTo evaluate the effectiveness of yokukansan, a traditional Japanese medicine, as treatment for nocturia due to sleep disorders.MethodsIn this study, we included patients diagnosed with nocturia due to sleep disorders, evaluated using the Pittsburgh Sleep Quality Index (PSQI). Participants received 2.5 g of yokukansan, three times daily, for 12 weeks. We evaluated the changes in the overactive bladder (OAB) symptom score (OABSS), hours of undisturbed sleep (HUS), and PSQI score. In addition, patients were categorized based on the severity of their sleep disorders, and we divided patients into two groups according to whether the severity of the disorder was downgraded after treatment: the improved and unchanged groups.ResultsAmong 35 patients with a mean ± standard deviation age of 73.2 ± 10.5 years, yokukansan administration was associated with significant improvements in nighttime urinary frequency (from 3.8 ± 2.1 to 2.1 ± 1.9), total OABSS score (from 4.9 ± 1.8 to 2.9 ± 1.9), OABSS urgency score (from 1.3 ± 1.0 to 0.7 ± 0.9), HUS (from 2.2 ± 0.6 to 3.5 ± 1.1 h), and global PSQI score (from 11.9 ± 3.1 to 10.0 ± 1.4; all p < 0.001). In addition, significant improvements were noted in both the improved and unchanged groups in terms of the total OABSS, nocturia, and urgency scores. Furthermore, yokukansan treatment was related to improved global PSQI scores in both groups (improved group: from 10.8 ± 0.7 to 8.6 ± 0.5, p = 0.001; unchanged group: from 12.3 ± 3.4 to 10.4 ± 1.3, p = 0.004).ConclusionYokukansan may effectively ameliorate nocturia due to sleep disorders.

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Efficacy of Fesoterodine on Nocturia and Quality of Sleep in Asian Patients With Overactive Bladder

Cited by 22 publications

References 25 publications

Association of Pharmacologic Treatment of Urgency Urinary Incontinence With Sleep Quality and Daytime Sleepiness

Association of Pharmacologic Treatment of Urgency Urinary Incontinence With Sleep Quality and Daytime Sleepiness

Fesoterodine clinical efficacy and safety for the treatment of overactive bladder in relation to patient profiles: a systematic review

Effectiveness of Japanese traditional medicine yokukansan for nocturia due to sleep disorders

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