Efficacy of factor IX <scp>G</scp>rifols<sup>®</sup> in surgery: experience of an international multicentre retrospective study

Pérez-Garrido, Rosario; Alonso, Nieves; Jiménez‐Yuste, Víctor; Haya, Saturnino; Zúñiga, Pamela; Baques, A Cols; Candela, M.; Davoli, M; Rescia, Virginia

doi:10.1111/j.1365-2516.2012.02919.x

Cited by 3 publications

(2 citation statements)

References 10 publications

(10 reference statements)

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“…Across all 35 publications, there was a wide range of surgical procedures categorized as being major or minor (Tables 1 and 2). 9,16 –42 Two articles defined surgical specialties (eg, orthopedic, cardiothoracic, neurosurgical), rather than individual procedures, as being major or minor. 18,40 In general, major surgical procedures were more likely to have been carried out under general anesthetic, while minor surgical procedures tended to be carried out under local anesthetic (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Major and Minor Classifications for Surgery in People With Hemophilia: A Literature Review

Solimeno

Escobar²,

Krassova

et al. 2017

Clin Appl Thromb Hemost

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Agents that control bleeding and the usage of bypassing agents have made surgery an option to consider in people with hemophilia. However, the lack of consistent definitions for major or minor surgery may lead to inconsistencies in patient management. This literature review has evaluated how surgical procedures in people with hemophilia were categorized as major or minor surgery and assessed the consistency across publications. After screening 926 potentially relevant articles, 547 were excluded and 379 full-text articles were reviewed. Ninety-five articles categorized major or minor surgical procedures; of these, 35 publications categorized three or more major or minor surgical procedures and were included for analysis. Seven (20%) publications provided varying criteria for defining major or minor surgery, five of which defined surgery according to the level of surgical invasiveness. Across all 35 publications, there was considerable variance in the categorization of major and minor surgical procedures and some overlap in surgical nomenclature (eg, type of synovectomy, arthroscopy, and central venous access device insertion/removals). The lack of consistent guidance when referring to major or minor surgery in people with hemophilia needs to be addressed. Clear and consistent definitions, achieved by consensus and promoted by relevant international hemophilia committees, are desirable, to provide guidance on appropriate treatment, to increase the accuracy of trial data and may confound the interpretation of surgical outcomes.

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Section: Resultsmentioning

confidence: 99%

Major and Minor Classifications for Surgery in People With Hemophilia: A Literature Review

Solimeno

Escobar²,

Krassova

et al. 2017

Clin Appl Thromb Hemost

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“…Se encontró que la mayoría de los estudios reportan niveles de éxito elevados considerados como excelente y bueno [14][15][16] , (88%). Sin embargo, algunos postularon la medición protocolizada de niveles de factores en sangre 17,18 así como sus propiedades farmacocinéticas, como punto de corte para determinar el éxito o fracaso del control hemostático (Figura 2).…”

Section: Resultsunclassified

Criterios de respuesta para definir éxito en la terapia de pacientes hemofílicos llevados a cirugía: Revisión ampliada de la literatura (RAL)

Casas¹,

Reyes²,

Solano³

et al. 2015

Repert. Med. Cir.

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ResumenLa hemofilia, enfermedad congénita de baja prevalencia en la población general, se clasifica en tipos A y B según su deficiencia sea del factor VIII o IX de la coagulación. Desde hace más de 40 años existen preparados plasmáticos de cada uno de los factores y en la actualidad contamos con derivados recombinantes. Los pacientes que requieren intervenciones quirúrgicas son un reto para los diferentes grupos de manejo, porque el estándar de criterios para definir la respuesta a la terapia no está claro. Se realizó esta revisión ampliada de la literatura con el fin de evaluar cuáles son los criterios de respuesta en las diferentes publicaciones. En las principales bases de datos médicos, se recolectaron y tabularon 61 artículos después de aplicar los criterios de inclusión y exclusión, encontrando que múltiples estudios aplicaban diferentes parámetros para evaluar el sangrado como son los niveles de factor de la coagulación, tromboelastografía, tiempo de generación de trombina, reintervención quirúrgica, duración de la hospitalización y evaluación de dolor, con lo cual concluimos que hay heterogeneidad en los parámetros que aplican los autores en relación con los objetivos principal y secundarios de nuestra revisión. Palabras clave: hemofilia, cirugía, desenlaces. AbstractHemophilia is an inherited low prevalence disorder among the general population classified as type A or B according to the deficiency of either coagulation factor VIII or IX. Coagulation factors in plasma prepared have been available for more than forty years, counting with recombinant factor products nowadays. Patients requiring surgical interventions are a challenge for treating physicians for the criteria standards of therapeutic response are not yet clear. This extended literature review was conducted to evaluate the therapeutic response criteria described in different publications. Sixty-one articles were retrieved from the main medical data bases and tabulated after applying the inclusion and exclusion criteria. Findings showed that many studies considered various parameters to monitor bleeding, such as, levels of coagulation factor, thromboelastography, thrombin generation time, surgical reintervention, length of hospital stay and level of pain. Thus, we conclude there is heterogeneity in the parameters authors apply regarding the primary and secondary objectives of our review.

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Management of severe perioperative bleeding

Kozek‐Langenecker

Ahmed

Afshari

et al. 2017

European Journal of Anaesthesiology

678

316

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: The management of perioperative bleeding involves multiple assessments and strategies to ensure appropriate patient care. Initially, it is important to identify those patients with an increased risk of perioperative bleeding. Next, strategies should be employed to correct preoperative anaemia and to stabilise macrocirculation and microcirculation to optimise the patient's tolerance to bleeding. Finally, targeted interventions should be used to reduce intraoperative and postoperative bleeding, and so prevent subsequent morbidity and mortality. The objective of these updated guidelines is to provide healthcare professionals with an overview of the most recent evidence to help ensure improved clinical management of patients. For this update, electronic databases were searched without language restrictions from 2011 or 2012 (depending on the search) until 2015. These searches produced 18 334 articles. All articles were assessed and the existing 2013 guidelines were revised to take account of new evidence. This update includes revisions to existing recommendations with respect to the wording, or changes in the grade of recommendation, and also the addition of new recommendations. The final draft guideline was posted on the European Society of Anaesthesiology website for four weeks for review. All comments were collated and the guidelines were amended as appropriate. This publication reflects the output of this work.

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Efficacy of factor IX Grifols^® in surgery: experience of an international multicentre retrospective study

Cited by 3 publications

References 10 publications

Major and Minor Classifications for Surgery in People With Hemophilia: A Literature Review

Major and Minor Classifications for Surgery in People With Hemophilia: A Literature Review

Criterios de respuesta para definir éxito en la terapia de pacientes hemofílicos llevados a cirugía: Revisión ampliada de la literatura (RAL)

Management of severe perioperative bleeding

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Efficacy of factor IX Grifols® in surgery: experience of an international multicentre retrospective study

Cited by 3 publications

References 10 publications

Major and Minor Classifications for Surgery in People With Hemophilia: A Literature Review

Major and Minor Classifications for Surgery in People With Hemophilia: A Literature Review

Criterios de respuesta para definir éxito en la terapia de pacientes hemofílicos llevados a cirugía: Revisión ampliada de la literatura (RAL)

Management of severe perioperative bleeding

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Efficacy of factor IX Grifols^® in surgery: experience of an international multicentre retrospective study