1979
DOI: 10.1002/cpt1979264502
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Efficacy of estradiol vaginal cream in postmenopausal women

Abstract: In a recent comparison of estradiol and conjugated estrogen creams,6 single intravaginal doses of both estrogens were well absorbed by postmenopausal women. Only the estradiol cream led to plasma estrone and estradiol levels of premenopausal women. Symptoms of menopause have largely been attributed to a decrease in estrogen secretion, a normal process of aging. While the question of the best mode of therapy is controversial, physiological replacement would be a logical choice for postmenopausal vasomotor sympt… Show more

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Cited by 20 publications
(10 citation statements)
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“…65 In seven elderly women (70-93 yrs) daily vaginal conjugated equine estrogen 0.625 mg/day cream resulted in estradiol and estrone concentrations on day 14 similar to those in the follicular phase. 63 Intravaginal micronized estradiol cream 0.2 mg produced estradiol concentrations of 60 31 to 70 32 pg/ml and estrone concentrations of 37 31 to 90 32 pg/ml. In five premenopausal women undergoing hormonal uterine stimulation for embryo transfer, estradiol 2-mg oral tablets inserted vaginally produced higher estradiol concentrations (2344 vs 279 pg/ml) than 2-mg tablets taken orally by five other women.…”
Section: Intravaginal Estrogensmentioning
confidence: 96%
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“…65 In seven elderly women (70-93 yrs) daily vaginal conjugated equine estrogen 0.625 mg/day cream resulted in estradiol and estrone concentrations on day 14 similar to those in the follicular phase. 63 Intravaginal micronized estradiol cream 0.2 mg produced estradiol concentrations of 60 31 to 70 32 pg/ml and estrone concentrations of 37 31 to 90 32 pg/ml. In five premenopausal women undergoing hormonal uterine stimulation for embryo transfer, estradiol 2-mg oral tablets inserted vaginally produced higher estradiol concentrations (2344 vs 279 pg/ml) than 2-mg tablets taken orally by five other women.…”
Section: Intravaginal Estrogensmentioning
confidence: 96%
“…Estrogens can partially or completely restore vaginal cytology, 22-24, 26, 28-37, 39, 40, 42, 43, 45-48, 50, 51, 53, 57 decrease vaginal pH to premenopausal levels, 22, 24, 37-39, 41, 43-45, 48-50 increase vaginal fluid secretions, 22, 24 mucosa thickness, 27,30,52 blood flow, 9,22,24 and sensorimotor response, 11 restore vaginal flora similar to premenopausal conditions, 27,30,44,59 and provide symptomatic relief. 21, 25, 29, 30, 32, 34, 37, 39-43, 45, 47-50, 53-59 Additional benefits are relief of other menopause symptoms, such as hot flushes, 25,31,32,40 improvements in urinary frequency and incontinence, 13,37,43,44,[47][48][49][50] and positive effects on bone density, 60 fractures, 60 and lipids. 28 Several issues are related to systemic absorption and duration of estrogen concentrations with estrogen products administered for various durations.…”
Section: Prescription Productsmentioning
confidence: 99%
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