Efficacy of Esophageal Impedance/pH Monitoring in Patients With Refractory Gastroesophageal Reflux Disease, on and off Therapy

Pritchett, Jason M.; Aslam, Muhammad; Slaughter, James C.; Ness, Reid M.; Garrett, C. Gaelyn; Vaezi, Michael F.

doi:10.1016/j.cgh.2009.02.022

Cited by 108 publications

(75 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hemmink et al ( 158 ) concluded that testing should be performed off PPI. In contrast, Pritchett et al ( 159 ) found that refl ux monitoring on PPI may be the preferred strategy. At present no single approach can be recommended due to the heterogeneous group of patients.…”

Section: Summary Of the Evidencementioning

confidence: 96%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,533

1,430

View full text Add to dashboard Cite

Section: Summary Of the Evidencementioning

confidence: 96%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,533

1,430

View full text Add to dashboard Cite

“…Вопрос об эффективности сочетанной диагностики импедансометрии с рН-мо-ниторингом для исключения гастроэзофагеально-го рефлюкса как причины ларингита, хронического кашля и астмы в доказательной медицине и мировой клинической практике остается открытым [16]. В ряде западных клиник для диагностики гастроэ-зофагеальной рефлюксной болезни у детей с грудного возраста в последнее десятилетие широко применя-ется суточный комбинированный импеданс-рН-мо-ниторинг [17]. Благодаря этому исследованию возможно выявить связь рефлюкса с симптомами болезни и диагностировать любой тип рефлюкса (кислый, слабокислый, слабощелочной, жидкостный или газовый), его значение особо велико у пациен-тов с внепищеводными формами гастроэзофагеаль-ного рефлюкса, поскольку жалобы может вызывать любой тип рефлюкса [18].…”

Section: оригинальные статьи в помощь практическому врачуunclassified

Extraoesophageal Manifestations of Gastroesophageal Reflux Disease in the Practice of Pediatric Otorhinolaryngologist

Асманов¹,

Ханакаева²,

Пивнева³

2017

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

“…The severity of symptoms was rated by means of a validated questionnaire. 10 Symptoms were graded as follows: 0 = none; 1 = mild/occasional, symptom could be ignored; 2 = moderate/frequent, symptom could not be ignored; and 3 = severe/constant, symptom influenced daily activities and/or sleep. For the inclusion criteria, asymptoms score of at least 2 was re-quired on PPI.…”

Section: Patientsmentioning

confidence: 99%

Diagnostic Utility of Impedance-pH Monitoring in Refractory Non-erosive Reflux Disease

Khan

Alaraj

Alsohaibani

et al. 2014

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/Aims Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to analyze symptom-reflux association and diagnose true NERD versus hyper-sensitive esophagus (HE) and functional heartburn (FH). Herein, we evaluated the diagnostic yield of MII-pH in refractory NERD and sub-classified it based on quantity and quality of acid/non-acid reflux and reflux-symptom association. Methods Sixty symptomatic NERD patients on twice daily PPI for > 2 months were prospectively evaluated by MII-pH. Distal and proximal refluxes, bolus exposure time (BET), esophageal acid exposure time, symptom index (SI) and symptom association probability (SAP) were measured. Results Thirty-two (53%) patients had BET > 1.4% (MII-pH positive-true NERD), while 28 (47%) had BET < 1.4% (MII-pH negative NERD) where SI and SAP were negative in 15/60 (25%; categorized as FH) and SI or SAP were positive in 13/60 (22%; identified as HE). Thirty-eight (63%) patients reported significant SI or SAP parameters where > 80% of symptoms were associated with non-acid reflux. The number of distal refluxes in true NERD versus FH or HE were significantly different, but not between FH and HE. Conclusions Approximately 60% of refractory PPI NERD patients had positive reflux-symptom association, primarily due to non-acid reflux. Nearly half of NERD patients on PPI had normal MII-pH monitoring, sub-divided further into FH and HE equally.

show abstract

Efficacy of Esophageal Impedance/pH Monitoring in Patients With Refractory Gastroesophageal Reflux Disease, on and off Therapy

Cited by 108 publications

References 21 publications

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Extraoesophageal Manifestations of Gastroesophageal Reflux Disease in the Practice of Pediatric Otorhinolaryngologist

Diagnostic Utility of Impedance-pH Monitoring in Refractory Non-erosive Reflux Disease

Contact Info

Product

Resources

About