Efficacy of epicardial implantation of acellular chitosan hydrogels in ischemic and nonischemic heart failure: impact of the acetylation degree of chitosan

Injectable hydrogel with dual-sensitive behavior for targeted delivery of oncostatin M to improve cardiac restoration after myocardial infarction

“…These results indicated that the CS-CA-PNIPAM hydrogel had a beneficial effect on cardiac function damage after MI, which might be ascribed to the injectable CS-CA-PNIPAM hydrogel, providing mechanical support and functional improvement to the disordered heart. 28 To validate the protective effect of OSM on the myocardium 54,55 as well as the important role of composite hydrogel in sustained release of OSM, we further compared the differences between injecting OSM solution and OSM@CS-CA-PNIPAM hydrogel. At 4 weeks post-injection, the OSM@CS-CA-PNIPAM hydrogel significantly improved cardiac function after MI.…”

“…[22][23][24] CS is well established as a suitable material for use in drug delivery systems: it is widely available, low-cost, biocompatible, and biodegradable. 23,[25][26][27] For example, the CS-based hydrogels show good biocompatibility and mechanical properties similar to the extracellular matrix, thus providing temporary structural support for the damaged myocardium when ventricular expansion is restricted at the infarction site, 28 and the enhanced release of bioactive factors can effectively improve cardiac function by protecting myocardial cells and promoting angiogenesis. 29 Given the low pH microenvironment in MI regions, suitable hydrogels are able to tolerate such conditions to deliver bioactive substances.…”

Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

“…1 B). When assessed in vivo , the chitosan hydrogel had low cell invasion when neutralized with NaOH; however, Domegngé et al improved such invasion by increasing the degree of acetylation within the chitosan hydrogel [ 143 , 144 ]. Further, Lin et al developed a viscoelastic epicardial patch made from ionically crosslinking a starch hydrogel with Ca(NO 3 ) 2 4H 2 O. Finite element modeling and further testing in vivo illustrated the viscoelastic functionality of the patch was able to accommodate the cyclic mechanics of the heart and improve cardiac function at 4-weeks post-MI [ 145 ].…”

Engineering of injectable hydrogels associate with Adipose-Derived stem cells delivery for anti-cardiac hypertrophy agents

“…After 28 days of post-administration, the region and dimensions of the patient party were semi contracted by the middle part of the papillary muscles (Thi et al, 2020;Sack et al, 2020;Domeng e et al, 2021). In the ADSC-ASS@L hydrogels and control-treated classes, the successor wall width associated with the saline treatment community was later shown to establish cardiomyocyte survival of the per infarct portion.…”