Efficacy of Endoscopic Ultrasound-guided Celiac Plexus Block and Celiac Plexus Neurolysis for Managing Abdominal Pain Associated With Chronic Pancreatitis and Pancreatic Cancer

Kaufman, Marina; Singh, Gurpreet; Das, Sourish; Concha-Parra, Ronald; Erber, Jonathan A.; Micames, Carlos G.; Gress, Frank G.

doi:10.1097/mcg.0b013e3181bb854d

Cited by 264 publications

(157 citation statements)

References 28 publications

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“…Interventional procedures such as coeliac plexus block may be considered 6 , whereas early involvement of a chronic pain team ensures treatment tailored to the needs of the patient and maintenance of quality of life. When these measures fail, and in a carefully selected subset of patients in whom substance abuse is not thought to be a confounding factor, it is logical to offer total pancreatectomy (TP).…”

Section: Introductionmentioning

confidence: 99%

Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis

Bramis

Gordon-Weeks

Friend

et al. 2012

British Journal of Surgery

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Background: Total pancreatectomy and islet autotransplantation (TP/IAT) is a treatment option in a subset of patients with chronic pancreatitis. A systematic review of the literature was performed to evaluate the outcome of this procedure, with an attempt to ascertain when it is indicated. The impact on quality of life was poorly reported. The studies reviewed did not provide evidence for optimal timing of TP/IAT in relation to the evolution of chronic pancreatitis. Conclusion:This systematic review showed that TP/IAT had favourable outcomes with regard to pain reduction. Concurrent IAT enabled a significant proportion of patients to remain independent of insulin supplementation.

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Section: Introductionmentioning

confidence: 99%

Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis

Bramis

Gordon-Weeks

Friend

et al. 2012

British Journal of Surgery

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“…Short-term pain improvement was approximately 50%, whereas long term pain relief at 24 wk was only 10%. A similar number has been achieved for shortterm pain relief by Kaufman et al [102] . Given the low long-term success rates, EUS-guided celiac block should be considered as a temporary measure.…”

Section: Eus-guided Celiac Plexus Blockmentioning

confidence: 57%

Endoscopic management of chronic pancreatitis

Oza

Kahaleh²

2013

WJGE

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Chronic pancreatitis (CP) is a common gastrointestinal illness, which affects the quality of life with substantial morbidity and mortality. The management includes medical, endoscopic and surgical approaches with the need for interaction between various specialties, calling for a concerted multidisciplinary approach. However, at the time of this publication, guidelines to establish care of these patients are lacking. This review provides the reader with a comprehensive overview of the studies summarizing the various treatment options available, including medical, surgical and endoscopic options. In addition, technological advances such as endoscopic retrograde cholangiopancreatogrophy, endoscopic shock wave lithotripsy and endoscopic ultrasound can now be offered with reasonable success for pancreatic decompression, stricture dilatation with stent placement, stone fragmentation, pseudocyst drainage, and other endoscopic interventions such as celiac plexus block for pain relief. We emphasize the endoscopic options in this review, and attempt to extract the most up to date information from the current literature. The treatment of CP and its complications are discussed extensively. Complications such as biliary strictures. pancreatic pseudocysts, and chronic pain are common issues that arise as long-term complications of CP. These often require endoscopic or surgical management and possibly a combination of approaches, however choosing amongst the various therapeutic and palliative modalities while weighing the risks and benefits, makes the management of CP challenging. Treatment goals should be not just to control symptoms but also to prevent disease progression. Our aim in this paper is to advocate and emphasize an evidence based approach for the management of CP and associated long term complications.

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“…The mean rate of pain alleviation is 72-80%, with a much lower rate of complete pain response [139][140][141]. The post-neurolytic residual pain could be related to non-visceral pain owing to invasion of the muscles or surrounding connective tissue.…”

Section: Pain Palliation By Eus-guided Celiac Plexus Neurolysismentioning

confidence: 99%

Endoscopic Ultrasound in Pancreatic Cancer: The New Perspective

Seicean¹

2014

Pancreatic Cancer - Insights Into Molecular Mechanisms and Novel Approaches to Early Detection and Treatment

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Efficacy of Endoscopic Ultrasound-guided Celiac Plexus Block and Celiac Plexus Neurolysis for Managing Abdominal Pain Associated With Chronic Pancreatitis and Pancreatic Cancer

Cited by 264 publications

References 28 publications

Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis

Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis

Endoscopic management of chronic pancreatitis

Endoscopic Ultrasound in Pancreatic Cancer: The New Perspective

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