Efficacy of endoscopic management of primary central nervous system lymphoma: a multicentric study and literature review

Ganau, Mario; Zaed, Ismail; Todeschi, Julien; Prisco, Laura; Cébula, H.; Bruno, Carmen; Spatola, Giorgio; Ligarotti, Gianfranco K.I.; Alessandrello, Raffaele; Fricia, Marco; Pop, Raoul; Baloglu, Seyyid; Savarese, Luciano; Scibilia, Antonino; Nannavecchia, Beniamino; Proust, F.; Chibbaro, Salvatore

doi:10.1007/s11060-022-04081-w

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“…[67] A study of 4812 PCNSL cases from the SEER database in the United States showed that complete or partial resection of the tumor improved the prognosis and survival time of patients. [68] Mario et al [69] reported good results for neuroendoscopic resection of intracerebroventricular PCNSL treatment. Patients with PCNSL who received adjuvant radiation therapy (RT) after surgery had a significant survival advantage, according to Kinslow et al [70] Thus, numerous variables affect the decision regarding whether surgery can benefit a patient with PCNSL.…”

Section: Discussionmentioning

confidence: 99%

Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review

Chen,

Yan,

et al. 2023

Medicine

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Rationale: Non-Hodgkin lymphoma affecting the brain, eyes, and cerebrospinal fluid without systemic spread is known as primary central nervous system lymphoma (PCNSL). While intracerebroventricular PCNSL is commonly found in the lateral ventricles and the third and fourth ventricles, the occurrence of PCNSL originating from the septum pellucidum is extremely rare. Patient Concerns: Two patients presented with recent memory loss and high cranial pressure. Diagnoses: Magnetic resonance imaging revealed a clear enhancing lesion in the septum pellucidum region. Pathological examination confirmed that both cases were primary large B-cell lymphoma GCB (germinal center B-cell-like) subtypes located in an “immune-privileged” area. Interventions: Both patients underwent total tumor resection, and the procedures were successfully completed without surgical complications. Outcomes: Over a 1-year period, treatment included four cycles of high-dose methotrexate combined with temozolomide. During the follow-up period (19–23 months), no recurrence of the lymphoma was observed. Lessons: In cases of PCNSL in the septum pellucidum, it is crucial to consider it as a potential differential diagnosis for intraventricular tumors. Surgical interventions should focus on maximizing tumor resection while ensuring the protection of critical structures like the fornix and peripheral neural components. The role of surgery compared to biopsy, as well as the long-term complications, necessitates extended follow-up. Additionally, an individualized treatment approach, considering factors such as age, Karnofsky performance score, and organ function assessment, can lead to positive outcomes.

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Section: Discussionmentioning

confidence: 99%