Efficacy of EMD versus calcium hydroxide in direct pulp capping of primary molars: a randomized controlled clinical trial

Garrocho‐Rangel, Arturo; Flores, Héctor; Silva-Herzog, Daniel; Hernández-Sierra, Francisco; Mandeville, Peter B; Pozos‐Guillén, Amaury

doi:10.1016/j.tripleo.2008.12.017

Cited by 34 publications

(41 citation statements)

References 23 publications

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“…Our study found a lower clinical and radiographic overall success rate in the Ca(OH) 2 -treated group compared to those of some previous studies, including Tuna and Olmez (2008) and Garrocho-Rangel et al (2009) [11,17]. This may be due to the differing methodologies of these other studies.…”

Section: Discussioncontrasting

confidence: 86%

“…When complete caries removal resulted in a pinpoint pulpal exposure (less than 1 mm in diameter), the exposure and surrounding areas were rinsed with sterile normal saline solution and 2.5 % sodium hypochlorite to remove debris and to disinfect the area. DPC was performed when the appearance of the exposure site was bright red and hemostasis was obtained using a moist cotton pellet with light pressure for 2-3 min [17]. If the pulp was not exposed after completely removing the caries, the tooth was restored and the patient was excluded from the study.…”

Section: Clinical Proceduresmentioning

confidence: 99%

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Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes

et al. 2015

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Acemannan has been previously reported as a direct pulp-capping agent in animal study. This natural material demonstrated its biocompatibility and enhanced reparative dentin formation. The objective of this study was to investigate the action of acemannan as a direct pulp-capping material in human primary teeth with deep caries. Forty-two deeply carious mandibular primary molars from 37 children, aged 7-11 years old diagnosed with reversible pulpitis were studied. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: acemannan or calcium hydroxide. A glass-ionomer cement base was applied to all teeth prior to restoration with stainless steel crowns. Clinical and radiographic evaluation was performed 6 months post-treatment. The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tissue organization. At 6 months, the overall clinical and radiographic success rates of direct pulp capping with acemannan and calcium hydroxide at 6 months were 72.73 and 70.0 %, respectively. The histopathological results indicated that the acemannan-treated group had significantly better histopathological responses compared with the calcium hydroxide-treated group (p < 0.05). These data suggest acemannan offers a valuable alternative biomaterial for vital pulp therapy in primary teeth.

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Section: Discussioncontrasting

confidence: 86%

Section: Clinical Proceduresmentioning

confidence: 99%

Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes

et al. 2015

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“…39 EMD, kalsiyum hidroksit ile benzer şekilde etki etmekte hatta kalsiyum hidroksitten daha etkili olduğu saptanmıştır. Bütün bu sonuçlardan sonra EMD'nin kalsiyum hidroksit gibi kliniklerde vital pulpa tedavilerinde kullanılabileceği saptanmıştır.…”

Section: Nakamura Ve Arkunclassified

Diş hekimliğinde Emdogain

Özerol¹,

Yilmaz²,

Bodrumlu³

2014

Acta Odontol Turc

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ÖZETBir mine matriks türevi olan Emdogain (EMD), dişi destekleyen dokuların rejenerasyonunda klinik olarak kullanılan bir materyaldir. EMD, yüzey detoksifikasyonu, demineralizasyonu ve kollajen liflerin açığa çıkması ve biyouyumlu bir yüzey oluşturulmasını sağlamaktadır. EMD, alkalin fosfataz aktivitesini ve osteoblastlardaki kemik matriks proteinlerinin salınımını arttırmaktadır. Amelogeninler mezenşimal hücreleri stimüle ederek iyileşme, büyüme ve rejenerasyon için gerekli olan faktörlerin açığa çıkmalarını sağlamaktadır. Amelogenin içerikli emdogainin endodontide, periodontolojide, implantolojide ve travmatolojide kemik ve yara iyileşmesi ve vital pulpa tedavilerinde kullanı-larak doku rejenerasyonlarında alternatif bir uygulama metodu olduğu görülmüştür. ANAHTAR KELİMELER: Amelin; amelogenin; emdogain; kalsiyum hidroksit; mine matriks proteinleri; rejenerasyon KAYNAK GÖSTERMEK İÇİN: Özerol NB, Yılmaz NA, Bodrumlu E.

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“…99 A commercial preparation, Emdogain (Straumann), containing amelogenin and an amelin protein-rich fraction in a gel form, has been clinically compared with good success to calcium hydroxide as direct pulp-capping agents in primary teeth. 116 The vast array of bioactive molecules that either have been shown to be or that may be involved in pulp and dentin repair have been reviewed by numerous authors (see Goldberg and Smith 10 and Goldberg et al 117 as examples).…”

Section: Bioactive Moleculesmentioning

confidence: 99%

Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration?

2010

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Understanding outcomes of the interaction between a dental material and tooth tissue is important in terms not only of biocompatibility but also of the potential for the material to modulate the response of the tissue. This interaction is influenced by many factors, including the chemistry of the material and any of its eluted components or degradation products, and the manner in which the tissue responds to these agents. Past studies of this interaction have primarily been aimed at identifying cytotoxic effects. More recently, investigations have focused on specific cellular responses, and in particular, on understanding how the materials themselves actually may contribute to regenerative processes in the tooth. Recent work has demonstrated the solubilization of proteins from dentin exposed to certain materials, such as calcium hydroxide, mineral trioxide aggregate, and acidic solutions that relate to those used in dentin bonding agents, with the subsequent modulation by these proteins of gene expression in odontoblast-like cells. This work suggests that dentin bridge formation under such materials may be stimulated through this process. Thus, there is much merit in examining both how new dental materials can be developed and how more traditional ones can be modified to preferentially stimulate regenerative processes when preferred. This review summarizes current knowledge about the potential beneficial effects derived from the interaction of dental materials with the dentin-pulp complex, as well as potential future developments in this exciting field.

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Efficacy of EMD versus calcium hydroxide in direct pulp capping of primary molars: a randomized controlled clinical trial

Cited by 34 publications

References 23 publications

Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes

Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes

Diş hekimliğinde Emdogain

Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration?

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