Efficacy of Early Treatment with Carbamazepine in Prevention of Neuropathic Pain in Patients with Spinal Cord Injury

Salinas-Durán, Fabio; Lugo, Luz Helena; García, Héctor Iván

doi:10.1097/phm.0b013e3182643c85

Cited by 36 publications

(24 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Time since injury was recorded in 5 of the 13 studies, 17,19,20,22,23 with a duration range of 1 month-396 months post injury. The cause of spinal cord injury was reported in 4 of the 13 studies; 15,18,21,23,25 these included: hemorrhage, surgery, infection, tumor, firearm and other weapons, falls, prolapsed disk, sports, diving, transverse myelitis, ischemia and motor vehicle accidents. When reporting the type of pain being examined, Cardenas et al 15 was the only article to mention taxonomy, that is, the Bryce-Ragnarsson taxonomy.…”

Section: Participant Characteristicsmentioning

confidence: 99%

“…15,17,18,21,[24][25][26] Number of participants with complete injury ranged from 5 26 -106, 15 while number of participants with incomplete injury ranged from 10 17,24 -105. 15 Level of injury (tetraplegia or paraplegia) was reported in 7 of the 13 studies; 16,20,22,23,[25][26][27] with a range of 4 16 -58 22 participants with tetraplegia and 6 23 -79 22 for participants with paraplegia.…”

Section: Participant Characteristicsmentioning

confidence: 99%

“…[15][16][17][18][19][20][21][22][23][24] The most popular design for intervention studies which met inclusion criteria was the double-blind crossover trial (n ¼ 4), 16,18,19,23 followed by the double-blind parallel-group trial (n ¼ 3). 21,22,24 One study had a double-blind, triple crossover RCT design. 20 Other designs included: 1 pre-post study, 25 1 longitudinal observational study 26 and 1 retrospective chart review.…”

Section: Study Design and Qualitymentioning

confidence: 99%

“…Power calculations were provided in 7 studies. 15,[18][19][20][21][22]24 Sample size ranged from 14 23 to 219 15 participants.…”

Section: Study Design and Qualitymentioning

confidence: 99%

“…The following drugs were examined in the remaining studies: valproate, 16 lamotrigine, 17 levetiracetam, 18 and carbamazepine. 21 All studies used an oral route of administration.…”

Section: Study Design and Qualitymentioning

confidence: 99%

See 4 more Smart Citations

Anticonvulsant medication use for the management of pain following spinal cord injury: systematic review and effectiveness analysis

Guy

Mehta

Leff³

et al. 2013

Spinal Cord

View full text Add to dashboard Cite

Study design: Systematic review and effectiveness analysis. Objectives: Assess the effectiveness of anticonvulsants for the management of post spinal cord injury (SCI) neuropathic pain. Setting: Studies from multiple countries were included. Methods: CINAHL, Cochrane, EMBASE and MEDLINE were searched up to April 2013. Quality assessment was conducted using the Jadad and the Downs and Black tools. Effect sizes and odds ratios were calculated for primary and secondary outcome in the included studies. Results: Gabapentinoids, valproate, lamotrigine, levetiracetam and carbamazepine were examined in the 13 included studies, ten of which are randomized controlled trials. Large effect size (0.873-3.362) for improvement of pain relief was found in 4 of the 6 studies examining the effectiveness of gabapentin. Pregabalin was shown to have a moderate to large effect (0.695-3.805) on improving neuropathic pain post SCI in 3 studies. Valproate and levetiracetam were not effective in improving neuropathic pain post SCI, while lamotrigine was effective in reducing neuropathic pain amongst persons with incomplete lesions and carbamazepine was found effective for relief of moderate to intense pain. Conclusion: Gabapentin and pregabalin are the two anticonvulsants which have been shown to have some benefit in reducing neuropathic pain.

show abstract

Section: Participant Characteristicsmentioning

confidence: 99%

Section: Participant Characteristicsmentioning

confidence: 99%

Section: Study Design and Qualitymentioning

confidence: 99%

“…Power calculations were provided in 7 studies. 15,[18][19][20][21][22]24 Sample size ranged from 14 23 to 219 15 participants.…”

Section: Study Design and Qualitymentioning

confidence: 99%

“…The following drugs were examined in the remaining studies: valproate, 16 lamotrigine, 17 levetiracetam, 18 and carbamazepine. 21 All studies used an oral route of administration.…”

Section: Study Design and Qualitymentioning

confidence: 99%

See 3 more Smart Citations

Anticonvulsant medication use for the management of pain following spinal cord injury: systematic review and effectiveness analysis

Guy

Mehta

Leff³

et al. 2013

Spinal Cord

View full text Add to dashboard Cite

show abstract

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults

Wiffen

Derry²,

Moore³

et al. 2014

Cochrane Database of Systematic Reviews

103

View full text Add to dashboard Cite

2 studies Death not reported 4 not calculated 44 participants 1 study Very low Denominator = all potentially exposed GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

show abstract

Effects of early intravesical administration of resiniferatoxin to spinal cord‐injured rats in neurogenic detrusor overactivity

Oliveira

Coelho

Franquinho

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

Objectives To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid‐1 (TRPV1), would silence TRPV1‐expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. Materials and Methods Rats submitted to largely incomplete spinal cord transection at T8/9 spinal segment were treated with intravesical RTX (50 nM) or its vehicle during spinal shock. Four weeks after spinal lesion, bladder‐reflex activity was evaluated by cystometry under urethane anesthesia, after which the bladder, spinal cord, and dorsal root ganglia were collected and processed. Results We found improvements on bladder function several weeks after early intravesical RTX administration, including a marked decrease of intravesical pressures and amplitude of bladder contractions. Such strong long‐lasting urodynamic effects resulted from the very potent desensitizing activity of RTX on peripheral terminals of sensory afferents, an effect restricted to the bladder. Conclusion Our results support that an early intervention with RTX could potentially attenuate NDO development and ensuing urinary incontinence, with a dramatic impact on the quality of life of spinal cord injury patients.

show abstract

Efficacy of Early Treatment with Carbamazepine in Prevention of Neuropathic Pain in Patients with Spinal Cord Injury

Abstract: Early intervention with carbamazepine decreased NP incidence at the 1-month but not at the 3- and 6-month follow-ups in the group of patients with acquired spinal cord injury.

Cited by 36 publications

References 8 publications

Anticonvulsant medication use for the management of pain following spinal cord injury: systematic review and effectiveness analysis

Anticonvulsant medication use for the management of pain following spinal cord injury: systematic review and effectiveness analysis

Carbamazepine for chronic neuropathic pain and fibromyalgia in adults

Effects of early intravesical administration of resiniferatoxin to spinal cord‐injured rats in neurogenic detrusor overactivity

Contact Info

Product

Resources

About