Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy

Horiya, Madoka; Hisano, Michi; Iwasaki, Yuma; Hanaoka, Masachi; Watanabe, Noriyoshi; Ito, Yushi; Kojima, Jun; Sago, Haruhiko; Murashima, Atsuko; Kato, Tatsuo; Yamaguchi, Koushi

doi:10.1097/aog.0b013e31822e5c02

Cited by 23 publications

(43 citation statements)

References 24 publications

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“…Before vaccination, a cross-reactive antibody to the 2009 H1N1 influenza virus was detected in 6-9% of people aged 18-64 years and 33% of those aged >60 years. In our study [9], the pre-vaccination antibody positivity rate among 124 pregnant women demonstrated a similar rate (7.2%). For the novel influenza A (H1N1) virus, few women of childbearing age had pre-existing antibodies and the initial vaccine formulation available was monovalent, in contrast to the trivalent seasonal vaccines.…”

Section: Discussionsupporting

confidence: 78%

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Usefulness of influenza vaccination during pregnancy to mothers and young infants

Hisano

Yamaguchi

2012

Expert Review of Vaccines

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As pregnant women are at increased risk of influenza infection and influenza-related complications, immunization with inactivated influenza vaccine during the influenza season is recommended. Vaccination during pregnancy is considered to provide benefits for both the mothers and their young infants. In 2009, the novel influenza A (H1N1) virus was reported worldwide to be the cause of a widespread outbreak of acute febrile respiratory illness. The efficacy and efficiency of monovalent vaccine against 2009 H1N1 influenza virus during pregnancy has already been confirmed in several studies. This article provides further useful information regarding the persistence of maternal antibodies and the transplacental transfer of antibodies following vaccination by comparison with natural influenza infection.

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Section: Discussionsupporting

confidence: 78%

“…A single dose of monovalent vaccine against 2009 H1N1 influenza virus showed a favorable immune response in pregnant women [9,10]. The efficiency of vaccination during pregnancy was not influenced by maternal immunological status or by the gestational stage when the vaccine was received [9].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of influenza vaccination during pregnancy to mothers and young infants

Hisano

Yamaguchi

2012

Expert Review of Vaccines

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“…Across strains, 95–100% of infants achieved a titer of 1:40 while 50–93% achieved a titer of 1:110. These comparatively high titer values in cord blood versus maternal serum reflect active transport mechanisms; cord blood antibodies including influenza-specific IgG typically considerably exceed maternal levels [35–37], as observed in the current study. However, there are a number of factors that can impede transfer of antibody, and thus higher titers in neonates versus mothers is not observed in all studies [9].…”

Section: Commentmentioning

confidence: 63%

Effects of prior influenza virus vaccination on maternal antibody responses: Implications for achieving protection in the newborns

Christian

Beverly

Mitchell

et al. 2017

Vaccine

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Background In the US, influenza vaccination is recommended annually to everyone ≥ 6 months. Prior receipt of influenza vaccine can dampen antibody responses to subsequent vaccination. This may have implications for pregnant women and their newborns, groups at high risk for complications from influenza infection. Objective This study examined effects of prior vaccination on maternal and cord blood antibody levels in a cohort of pregnant women in the US. Study Design Influenza antibody titers were measured in 141 pregnant women via the hemagglutination inhibition (HAI) assay prior to receipt of quadrivalent influenza vaccine, 30 days post-vaccination, and at delivery (maternal and cord blood). Logistic regression analyses adjusting for age, BMI, parity, gestational age at vaccination, and year of vaccination compared HAI titers, seroprotection, and seroconversion in women with versus without vaccination in the prior year. Results Compared to those without vaccination in the previous year (n=50), women with prior vaccination (n=91) exhibited higher baseline antibody titers and/or seroprotection rates against all four strains after controlling for covariates. Prior vaccination also predicted lower antibody responses and seroconversion rates at one month post-vaccination. However, at delivery, there were no significant differences in antibody titers or seroprotection rates in women or newborns, and no meaningful differences in the efficiency of antibody transfer, as indicated by the ratio of cord blood to maternal antibody titers at the time of delivery. Conclusion In this cohort of pregnant women, receipt of influenza vaccine the previous year predicted higher baseline antibody titers and decreased antibody responses at one month post-vaccination against all influenza strains. However, prior maternal vaccination did not significantly affect either maternal antibody levels at delivery or antibody levels transferred to the neonate. This study is registered with the NIH as a clinical trial (NCT02148874).

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“…Accordingly, three comparisons were made: 2nd‐trimester vaccination compared with 1st‐trimester vaccination, the 3rd trimester compared with the 2nd and the 3rd trimester compared with the 1st. For studies that included a two‐dose vaccine group, these data were analysed in separate meta‐analyses (trimester of vaccination defined by the timing of the first dose) . Seven primary meta‐analyses (Figure & Figures , , , ) were conducted, plus four separate meta‐analyses of results after a second dose (Figures , , , ).…”

Section: Methodsmentioning

confidence: 99%

Optimal timing of influenza vaccine during pregnancy: A systematic review and meta‐analysis

Cuningham

Geard

Fielding

et al. 2019

Influenza Resp Viruses

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Background Pregnant women have an elevated risk of illness and hospitalisation from influenza. Pregnant women are recommended to be prioritised for influenza vaccination during any stage of pregnancy. The risk of seasonal influenza varies substantially throughout the year in temperate climates; however, there is limited knowledge of how vaccination timing during pregnancy impacts the benefits received by the mother and foetus. Objectives To compare antenatal vaccination timing with regard to influenza vaccine immunogenicity during pregnancy and transplacental transfer to their newborns. Methods Studies were eligible for inclusion if immunogenicity to influenza vaccine was evaluated in women stratified by trimester of pregnancy. Haemagglutination inhibition (HI) titres, stratified by trimester of vaccination, had to be measured at either pre‐vaccination and within one month post‐vaccination, post‐vaccination and at delivery in the mother, or in cord/newborn blood. Authors searched PubMed, Scopus, Web of Science and EMBASE databases from inception until June 2016 and authors of identified studies were contacted for additional data. Extracted data were tabulated and summarised via random‐effect meta‐analyses and qualitative methods. Results Sixteen studies met the inclusion criteria. Meta‐analyses found that compared with women vaccinated in an earlier trimester, those vaccinated in a later trimester had a greater fold increase in HI titres (1.33‐ to 1.96‐fold) and higher HI titres in cord/newborn blood (1.21‐ to 1.64‐fold). Conclusions This review provides comparative analysis of the effect of vaccination timing on maternal immunogenicity and protection of the infant that is informative and relevant to current vaccine scheduling for pregnant women.

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Efficacy of Double Vaccination With the 2009 Pandemic Influenza A (H1N1) Vaccine During Pregnancy

Abstract: III.

Cited by 23 publications

References 24 publications

Usefulness of influenza vaccination during pregnancy to mothers and young infants

Usefulness of influenza vaccination during pregnancy to mothers and young infants

Effects of prior influenza virus vaccination on maternal antibody responses: Implications for achieving protection in the newborns

Optimal timing of influenza vaccine during pregnancy: A systematic review and meta‐analysis

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