Efficacy of dopamine and norepinephrine for treatment of hemodynamic compromise in amitriptyline intoxication

Part 12: Cardiac Arrest in Special Situations

“…[335][336][337][338][339][340][341][342] Serum sodium levels and pH should be monitored, and severe hypernatremia (sodium Ͼ155 mEq/L) and alkalemia (pH Ͼ7.55) should be avoided. A number of vasopressors and inotropes have been associated with improvement in the treatment of tricyclic-induced hypotension, ie, epinephrine, 239,344,345 norepinephrine, [345][346][347][348] dopamine, 348 -350 and dobutamine. 349 …”

Part 8: Advanced Life Support

“…612 The evidence for the efficacy of specific antidysrhythmics (lidocaine, magnesium, amiodarone, phenytoin) was limited to negative case reports (LOE 5). 612 625,627,628 and dobutamine (LOE 5). 627 Diazepam improved seizure control and survival in 1 animal study (LOE 5).…”

Therapeutic Approach to the Critically Poisoned Patient

“…In a dog model, TCA-induced hypotension was equally responsive to dopamine and norepinephrine. Only high-dose dopamine infusions of 15 μg/kg/min or higher (α-range) were as effective, however, as low doses of norepinephrine (0.25 μg/kg/min) [97]. There is some evidence that norepinephrine may be the initial vasopressor of choice for TCA-induced hypotension [96].…”