Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of Trypanosoma evansi in mice model

Aregawi, Weldegebrial G.; Gutema, Fikadu; Bekele, Juhar Tesfaye; Sorsa, Abel; Megersa, Brehanu; Teshome, Philimon; Agga, Getahun E.; Ashenafi, Hagos

doi:10.1007/s12639-020-01289-3

Cited by 5 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clearance time, relapse and survivability are acknowledged as principal pointers of trypanocide efficacy (Osondu et al, 2016;Aregawi et al, 2021). Thus, the shorter clearance time (4 days PT) observed in groups 3 and 4 rats against the group 6 rats (14 days PT) may be attributed to the fact that treatments were instituted at different periods and the level of parasitaemia varied in each infected group at the time of treatment, with group 6 which was treated at day 14 PI having the highest parasitaemia level.…”

Section: Discussio Discussio Discussio Discussion N N Nmentioning

confidence: 99%

Effect of time of treatment on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei

EZEH,

IHEAGWAM,

OBI

et al. 2023

Not Sci Biol

View full text Add to dashboard Cite

The effect of treatment time on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei was assessed. The thirty albino rats utilized in this study were divided into six groups, each with five rats. Group 1 rats were uninfected while those in groups 2 - 6 were inoculated intraperitoneally with 106 trypanosomes. Group 2 rats were left untreated while groups 3 - 6 rats were treated respectively on days 5, 8, 11 and 14 post infection (PI) with 1.0 mg/kg Securidium® (brand of isometamidium chloride) intraperitoneally. Level of parasitaemia, rectal temperature, clinical signs, haematological indices (packed cell volume and total leucocyte count) and survivability were used to evaluate the treatment time on the efficacy of Securidium®. Pre-patent period was 4 - 5 days. On days 4, 5, and 11 following the treatments (PT), the parasites were eliminated in the treated groups 3 - 6 respectively. Also, two rats relapsed in group 3 from 37 days PT with 20% mortality, whereas groups 4 - 6 rats relapsed from days 19, 16 and 21 PT respectively. Groups 4 - 6 rats had 40%, 60% and 80% mortalities respectively. The mean PCV and TLC showed a striking drop (p<0.05) PI, however, group 3 had a better result PT compared to other infected-treated groups. In conclusion, it is safe to say that treatment time is a significant determinant of therapeutic efficacy in trypanosomosis, as early treatment group had better overall indices of therapeutic efficacy than the late treatment groups.

show abstract

Section: Discussio Discussio Discussio Discussion N N Nmentioning

confidence: 99%

Effect of time of treatment on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei

EZEH,

IHEAGWAM,

OBI

et al. 2023

Not Sci Biol

View full text Add to dashboard Cite

show abstract

“…Contrary, the parasite is able to avoid hostspecific immune responses by virtue of its ability to make persistent alterations in variable surface glycoproteins (VSGs) [8]. Suramin is an ordinarily used drug for the treatment of surra in horses [9]. Understanding the mechanism of T. evansi host immune evasion would enable to create novel control techniques since there is currently no available vaccination to prevent surra [10].…”

mentioning

confidence: 99%

Histological and Immunohistochemical Assays of <i>Trypanosoma evansi</i> Infected Camel Hepatic Tissues

Jaber,

Algehani,

Almalki

et al. 2023

Pol. J. Environ. Stud.

View full text Add to dashboard Cite

Trypanosomiasis, also known as surra (from the Hindi word for "rotten"), is one of the most significant diseases afflicting animals in tropical and semitropical regions. It is brought on by the hemoparasite Trypanosoma evansi. Despite the fact that some wild animals as well as camels and horses are particularly susceptible to trypanosomiasis, infections and clinical cases have been reported in numerous different domesticated mammals. T. evansi can become endemic when introduced to a new area since it is distributed mechanically by several tabanids and other flies. Populations lacking or having weakened immunity

show abstract

Assessment of toxicity and anti-trypanosomal activities of toad venom in rat models

et al. 2022

View full text Add to dashboard Cite

Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of Trypanosoma evansi in mice model

Cited by 5 publications

References 38 publications

Effect of time of treatment on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei

Effect of time of treatment on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei

Histological and Immunohistochemical Assays of <i>Trypanosoma evansi</i> Infected Camel Hepatic Tissues

Assessment of toxicity and anti-trypanosomal activities of toad venom in rat models

Contact Info

Product

Resources

About